SOME DERIVATIVES OF DIALKOXY-PHTHALIDES

1944 ◽  
Vol 22b (4) ◽  
pp. 115-124 ◽  
Author(s):  
Richard H. F. Manske ◽  
Archie E. Ledingham
Keyword(s):  
Benzoic Acids ◽  
Chloromethyl Group ◽  
Fries Rearrangement ◽  
Derivatives Of

Treatment of certain dialkoxy-benzoic acids was found to yield dialkoxy-phthalides containing a chloromethyl group. The constitutions of a number of these compounds have been elucidated by unambiguous syntheses. Inter alia, it was observed that the Fries rearrangement of 4-acetoxy-3-methoxy-toluene yielded exclusively a m-hydroxy-acetophenone. This appears to be the only recorded case of an exclusive meta-rearrangement. Several intermediate aldehydes and some compounds derived from them are described.

SOME SULFONYL DERIVATIVES OF CAMPHOR, N-PHENYLSUCCINIMIDE, 2-AMINOPHENOL AND SUBSTITUTED BENZOIC ACIDS

1982 ◽  
Vol 12 (2) ◽  
pp. 197-204 ◽  
Author(s):  
Richard Cremlyn ◽  
Keith Burrell ◽  
Kenneth Fish ◽  
Ian Hough ◽  
Donovan Mason
Keyword(s):  
Benzoic Acids ◽  
Substituted Benzoic Acids ◽  
Derivatives Of

scholarly journals The Fries Rearrangement ofbz-Benzoyloxybenzofuran Derivatives and the Synthesis of the Furo Derivatives of 4-Phenyl-2H-chromen-2-one

1978 ◽  
Vol 51 (6) ◽  
pp. 1907-1908 ◽  
Author(s):  
Yoshiyuki Kawase ◽  
Seiji Yamaguchi ◽  
Kumiko Aoyama ◽  
Michiyo Matsuda
Keyword(s):  
Fries Rearrangement ◽  
Derivatives Of

Synthesis and modification of fillers with derivatives of benzoic acids

2003 ◽  
Vol 194 (1) ◽  
pp. 329-334 ◽  
Author(s):  
Michał Tyburczy ◽  
Marian Zaborski ◽  
Włodzimierz Baryń
Keyword(s):  
Benzoic Acids ◽  
Derivatives Of

XAS studies on Cu(II) complexes with derivatives of phenoxyacetic and benzoic acids

2012 ◽  
Vol 553 ◽  
pp. 59-63 ◽  
Author(s):  
Marcin T. Klepka ◽  
Aleksandra Drzewiecka ◽  
Anna Wolska ◽  
Wieslawa Ferenc
Keyword(s):  
Benzoic Acids ◽  
Derivatives Of

scholarly journals Fluorescent Sensors For Hg2+ and Cu2+ Based On Condensation Products of 4H-1,2,4 Triazole-4-Amine And Carboxylated Benzoic Acids

2021 ◽  
Author(s):  
Satyapriya Deka ◽  
Ankur K Guha ◽  
Diganta Kumar Das
Keyword(s):  
Benzoic Acid ◽  
Terephthalic Acid ◽  
Phthalic Acid ◽  
Copper Ion ◽  
Binding Constants ◽  
Isophthalic Acid ◽  
Benzoic Acids ◽  
Health Issues ◽  
Derivatives Of ◽  
Optimized Geometries

Abstract Mercury (Hg) causes serious health issues in its all forms. Deficiency as well as excess of copper ion (Cu2+) in human body is hazardous. A series of four compounds have been derived from carboxylated benzoic acids (benzoic acid, isophthalic acid, terephthalic acid and phthalic acid) and 4H-1,2,4 triazole-4-amine and characterized. Fluorescencce detection of Hg2+ was recorded by the derivates with benzoic acid and isophthalic acid while the derivatives of terephthalic acid and phthalic acid detect Cu2+ by fluorescence “off” mode. Metal ions like Li+, Na+, K+, Zn2+, Al3+, Mg2+, Mn2+, Co2+, Ni2+, Cu2+, Cd2+, Pb2+ and Hg2+ found not to interfere. The stoichiometry of binding is 1:1 for the benzoic acid derivative with Hg2+ while it is 1:2 for the other three derivatives. The binding constants are ca. 10− 4.5 between the sensors and Hg2+ or Cu2+ and detection limits are around 10− 5.5 M. DFT calculation provided optimized geometries of the sensors and confirmed the stoichiometry of binding with Hg2+/Cu2+.

scholarly journals SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE

2012 ◽  
Vol 12 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Muhammad Idham Darussalam Mardjan ◽  
Retno Ambarwati ◽  
Sabirin Matsjeh ◽  
Tutik Dwi Wahyuningsih ◽  
Winarto Haryadi
Keyword(s):  
Salicylic Acid ◽  
Carboxylic Acid ◽  
Acid Derivative ◽  
Ring Closure ◽  
Hydroxybenzoic Acid ◽  
Fries Rearrangement ◽  
Acetophenone Derivatives ◽  
Ft Ir ◽  
Benzaldehyde Derivatives ◽  
Derivatives Of

Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave methyl 4-acetoxybenzoate in 75% yield. Furthermore, solvent-free Fries rearrangement of methyl 4-acetoxybenzoate in the presence of AlCl3 produced 3-acetyl-4-hydroxybenzoic acid as the acetophenone derivatives in 67% yield. Then, Claisen-Schmidt condensation of the acetophenone and benzaldehyde derivatives of p-anisaldehyde and veratraldehyde in basic condition gave 2'-hydroxychalcone-5'-carboxylic acid derivatives  in 81 and 71 % yield, respectively. Finally, the ring closure reaction of the chalcone yielded the corresponding flavanone-6-carboxylic acids in 67 and 59% yield, respectively.

ChemInform Abstract: SYNTHESIS, ANTIBACTERIAL AND ANALGESIC ACTIVITIES OF BENZHYDRYL DERIVATIVES OF HYDROXY- AND AMINO-BENZOIC ACIDS

1979 ◽  
Vol 10 (52) ◽  
Author(s):  
S. TAKEMURA ◽  
H. TERAUCHI ◽  
Y. MIKI ◽  
L. NAKANO ◽  
Y. INAMORI ◽  
...  
Keyword(s):  
Benzoic Acids ◽  
Analgesic Activities ◽  
Derivatives Of

scholarly journals Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane

2015 ◽  
Vol 11 ◽  
pp. 2671-2676 ◽  
Author(s):  
Mohammed Salah Ayoup ◽  
David B Cordes ◽  
Alexandra M Z Slawin ◽  
David O'Hagan
Keyword(s):  
Functional Group ◽  
Building Blocks ◽  
Benzoic Acids ◽  
Molecular Scaffolds ◽  
Derivatives Of

Palladium catalysed carbonylation reactions using the meta- and para-iodo derivatives of all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane (4) are illustrated as the start point for a variety of functional group interconversions. The resultant benzaldehyde and benzoic acids offer novel building blocks for further derivatisation and facilitate the incorporation of the facially polarised all-cis-1,2,4,5-tetrafluorocyclohexane motif into more advanced molecular scaffolds.

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