Assessment and clinical relevance of the dynamic parameters of ventricular repolarization in patients with grade I left ventricular diastolic dysfunction

2019 ◽  
Vol 97 (6) ◽  
pp. 577-580
Author(s):  
Antoinette Oliveira Blackman ◽  
José Sobral Neto ◽  
Melchior Luiz Lima ◽  
Tânia Maria Andrade Rodrigues ◽  
Otoni Moreira Gomes
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Diastolic Dysfunction ◽  
Qt Dispersion ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Repolarization ◽  
Premature Ventricular Complex ◽  
Increased Risk ◽  
Ventricular Diastolic Dysfunction

Imbalance in ventricular repolarization parameters are related to increased risk of severe arrhythmia and sudden cardiac death. There is limited research regarding markers to detect patients at risk in this early stage. We aimed to assess the influence of grade I left ventricular diastolic dysfunction on repolarization parameters in asymptomatic patients. Ambulatory patients with grade I left ventricular diastolic dysfunction were studied and compared with a control group. We assessed the QT dispersion circadian variation, heart rate variability in the time and frequency domains, and dynamics of QT using a 12-lead Holter. In the diastolic dysfunction group, 8 (30%) patients had QT dispersion > 80 ms. One (3.8%) patient presented premature ventricular complex > 10/h. The comparison between the 2 groups showed that the difference between the standard deviation of normal-to-normal intervals and low frequency power in both groups was statistically significant. We therefore conclude that increased parameters of ventricular repolarization and depressed heart rate variability reflect an imbalance in autonomic responses in patients with grade I left ventricular diastolic dysfunction without cardiovascular symptoms, enabling the identification of patients that are at a higher risk for cardiovascular events.

scholarly journals Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects

2013 ◽  
Vol 36 (5) ◽  
pp. 255 ◽  
Author(s):  
Andrée-Anne Gagnon-Audet ◽  
Paul Poirier ◽  
Hélène Turcotte ◽  
Julie Martin ◽  
Marjorie Bastien ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiac Function ◽  
Diastolic Dysfunction ◽  
Cardiac Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Dysfunction ◽  
Severely Obese ◽  
Obese Subjects

Purpose: Obesity is associated with left ventricular diastolic dysfunction and altered heart rate variability, as well as pulmonary dysfunction. The relationship between asthma and cardiac dysfunction in severely obese subjects is unknown, although it has been hypothesized that cardiac dysfunction may contribute to increase airway hyper-responsiveness (AHR). This study aimed to determine if AHR is associated with left ventricular diastolic dysfunction and heart rate variability in severely obese subjects. Methods: Sixty-one subjects with severe obesity (BMI ≥35 kg/m2 with comorbidities) completed this study. All subjects completed respiratory questionnaires, spirometry, lung volume measurements, methacholine inhalation test, 24hour Holter monitoring and a complete echocardiography evaluation. Blood samples were obtained for measurement of metabolic markers. Subjects with AHR, defined by a provocative concentration of methacholine inducing a 20% fall in FEV1 (PC20) < 8 mg/ml, were compared with those with no AHR (PC20 ≥8 mg/ml). Results: According to these criteria, 32 subjects had AHR and 29 had no AHR(mean PC201.70 mg/ml and 15.3 mg/ml respectively, p < 0.001). The groups were similar for anthropometric data and comorbidities. Fasting glucose, Hb1Ac, total cholesterol, LDL, triglycerides, Apo-B, C-reactive protein (CRP) and pro-BNP levels were also comparable between groups (p > 0.05). CRP level correlated with PC20 (AHR, r=0.38, p=0.03). Indices of heart rate variability and overall cardiac function were similar in subjects with or without AHR but grade 2 left ventricular diastolic dysfunction was more prevalent in subjects with AHR (p=0.037). Conclusions: Altered cardiac function, dysglycemia and dyslipidemia do not seem to be significantly associated with AHR in severely obese subjects in contrast to systemic inflammation.

scholarly journals Association between Grade of Normoalbuminuria and Left Ventricular Diastolic Dysfunction (LVDD) in Hypertensive Population of Gunungsari Village, Pamijahan-Bogor, Indonesia

2019 ◽  
Vol 40 (2) ◽  
Author(s):  
Nur Zamiatun Qomara ◽  
Nani Hersunarti B ◽  
Anwar Santoso
Keyword(s):  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Vascular Medicine ◽  
Cross Sectional ◽  
Urine Albumin ◽  
Hypertensive Population ◽  
Increased Risk ◽  
Significant Difference ◽  
Ventricular Diastolic Dysfunction

Association between Grade of Normoalbuminuria and Left Ventricular Diastolic Dysfunction (LVDD) in Hypertensive Population of Gunungsari Village, Pamijahan-Bogor, Indonesia Nur Z Qomara MD, Nani Hersunarti MD, Anwar Santoso MDDepartement of Cardiology and Vascular Medicine Faculty of Universitas Indonesia  ABSTRACT  Background: Albuminuria has been considered an important diagnostic marker of decreasing renal function, but lately albuminuria has also been linked to cardiovascular and peripheral vascular disease. Many studies have analyzed the association between micro- or macroalbuminuria and the increased risk of cardiovascular disease, but only few examined the association between normoalbuminuria and cardiovascular disease.Objective: To analyze the association between the degree of normoalbuminuria and the occurrence of left ventricular diastolic dysfunction in hypertensive patients.Method: This is cross-sectional analysis in hypertensive patients. Normoalbuminuric subjects are divided into three tertiles based on the cutoff of Urine-Albumin-Creatinine Ratio (UACR). To evaluate left ventricular function, all subjects undergo echocardiography examination. Left ventricular diastolic dysfunction is positive if more than fifty percent of positive findings are present from the fourth parameters stated in the 2016 American Society of Echocardiography criterias.Results: No significant difference in the occurrence of LVDD was found between the two groups according to age, sex, smoking, dyslipidemia, physical activity, BMI, hypertension therapy and HbA1c, but a significant difference was seen in the UACR tertile of the two group. This study showed that upper-limit normoalbuminuria (third tertile) was associated with the occurrence of LVDD (OR 15.57, 95% CI: 2.88-84.25).Conclusion: This study showed that normoalbuminuria in hypertensive population is associated with left ventricular diastolic dysfunction. Keywords: hypertension, normoalbuminuria, left ventricular diastolic dysfunctio

CORRELATION AND CLINICAL SIGNIFICANCE OF CAROTID INTIMA MEDIA THICKNESS, HSCRP IN CEREBROVASCULAR STROKE

2021 ◽  
pp. 34-35
Author(s):  
Manoj Kumar Mathur ◽  
Ajeet Kumar Chaurasia ◽  
Poonam Gupta ◽  
Manish Yadav
Keyword(s):  
Diastolic Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Blood Parameter ◽  
Media Thickness ◽  
Increased Risk ◽  
Ventricular Diastolic Dysfunction ◽  
Cerebrovascular Stroke

OBJECTIVE: CIMT and hsCRP are strongly related with cerebrovascular stroke.This study was done to evaluate patients with cerebrovascular stroke, correlation of hsCRP, carotid intima media thickness with outcome. METHOD:This study was an observational cross-sectional study. The study was conducted in the Department of Medicine, MLN Medical College and SRN Hospital, Allahabad .All individuals aged ≥18 years . Ethical Committee approval was taken from Institutional Ethics Committee. Patient of CVA with symptoms lasting for more than 24 hours and admitted within 72 hours after the onset of stroke were included in the study. Routine blood parameter including CBC, LFT, KFT, electrolyte, lipid prole was done. HbA1c, hsCRP, CT Head/ MRI brain, Carotid Doppler to assess intima media thickness. RESULT: Total number of CVAcases selected for study was 100,out of which 77patients (77%) had ischaemia and 23 (23%)patients had haemorrhage.Mean age of ischaemic patient was (60.69±13.05) and mean age of haemorrhagic group was 67.74±13.79.In haemorrhagic group CIMT>0.5 mm was present in 21 % cases and CIMT <0.5mm was seen in only 2 cases.This was statistically signicant.In ischaemic group CIMT>0.5mm was present in 73 % cases and CIMT<0.5mm was 4% cases. This was also statistically signicant .CIMT was signicantly higher in haemorrhagic group. In haemorrhagic group hsCRP>3 was present in 20 cases (20%) as compared to only 3 patients with hsCRP <3. This was statistically signicant. Mean hsCRP level was higher in haemorrhagic group as compared to ischaemic group this correlate with increased risk of stroke in cases with hsCRPIn ischaemic group GCS<8 had higher hsCRPlevel as compared to cases of ischaemic stroke with GCS >8.In haemorrhagic group GCS<8 had lower hsCRPlevel as compared to cases of haemorrhagic stroke with GCS >8. CONCLUSION: Carotid intima media thickness was higher in haemorrhagic group as compared to ischaemic group. Haemorrhagic group (82.6%) had low GCS compare to ischaemic group (35.05%) while cases with haemorrhage have more left ventricular diastolic dysfunction in comparison to ischaemic cases. Carotid intima media thickness, triglyceride and more left ventricular diastolic dysfunction was higher in haemorrhagic group

Relation between stage of left ventricular diastolic dysfunction and QT dispersion

2003 ◽  
Vol 58 (4) ◽  
pp. 303-308 ◽  
Author(s):  
Huseyin GUNDUZ ◽  
Ramazan AKDEMIR ◽  
Emrah BINAK ◽  
Ali TAMER ◽  
Cihangir UYAN
Keyword(s):  
Diastolic Dysfunction ◽  
Qt Dispersion ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Dysfunction

scholarly journals Cirrhotic Cardiomyopathy

2021 ◽  
Vol 12 (1) ◽  
pp. 76-88
Author(s):  
Kieran Longley ◽  
Tuan Tran ◽  
Vincent Ho
Keyword(s):  
Heart Rate ◽  
Diastolic Dysfunction ◽  
Cardiac Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Cirrhotic Cardiomyopathy ◽  
Qt Interval Prolongation ◽  
Ventricular Diastolic Dysfunction

Cirrhotic cardiomyopathy (CCM), cardiac dysfunction in end-stage liver disease in the absence of prior heart disease, is an important clinical entity that contributes significantly to morbidity and mortality. The original definition for CCM, established in 2005 at the World Congress of Gastroenterology (WCG), was based upon known echocardiographic parameters to identify subclinical cardiac dysfunction in the absence of overt structural abnormalities. Subsequent advances in cardiovascular imaging and in particular myocardial deformation imaging have rendered the WCG criteria outdated. A number of investigations have explored other factors relevant to CCM, including serum markers, electrocardiography, and magnetic resonance imaging. CCM characteristics include a hyperdynamic circulatory state, impaired contractility, altered diastolic relaxation, and electrophysiological abnormalities, particularly QT interval prolongation. It is now known that cardiac dysfunction worsens with the progression of cirrhosis. Treatment for CCM has traditionally been limited to supportive efforts, but new pharmacological studies appear promising. Left ventricular diastolic dysfunction in CCM can be improved by targeted heart rate reduction. Ivabradine combined with carvedilol improves left ventricular diastolic dysfunction through targeted heart rate reduction, and this regimen can improve survival in patients with cirrhosis. Orthotopic liver transplantation also appears to improve CCM. Here, we canvass diagnostic challenges associated with CCM, introduce cardiac physiology principles and the application of echocardiographic techniques, and discuss the evidence behind therapeutic interventions in CCM.

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