An update on the association of vitamin D deficiency with common infectious diseases

2015 ◽  
Vol 93 (5) ◽  
pp. 363-368 ◽  
Author(s):  
Richard R. Watkins ◽  
Tracy L. Lemonovich ◽  
Robert A. Salata
Keyword(s):  
Vitamin D ◽  
Infectious Diseases ◽  
Vitamin D Deficiency ◽  
Health Care Facilities ◽  
Future Research ◽  
Therapeutic Implications ◽  
Increased Risk ◽  
Immunodeficiency Virus ◽  
Recent Developments ◽  
Future Research Directions

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.

scholarly journals Vitamin D and Cardiovascular Disease: An Updated Narrative Review

2021 ◽  
Vol 22 (6) ◽  
pp. 2896
Author(s):  
Armin Zittermann ◽  
Christian Trummer ◽  
Verena Theiler-Schwetz ◽  
Elisabeth Lerchbaum ◽  
Winfried März ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
High Risk ◽  
General Population ◽  
Vitamin D Deficiency ◽  
Specific Gene ◽  
Vitamin D Status ◽  
Cvd Risk ◽  
Severe Vitamin ◽  
Increased Risk

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.

scholarly journals Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?

2021 ◽  
Vol 22 (12) ◽  
pp. 6444
Author(s):  
Anna Gabryanczyk ◽  
Sylwia Klimczak ◽  
Izabela Szymczak-Pajor ◽  
Agnieszka Śliwińska
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Deficiency ◽  
Cancer Development ◽  
Increased Risk

There is mounting evidence that type 2 diabetes mellitus (T2DM) is related with increased risk for the development of cancer. Apart from shared common risk factors typical for both diseases, diabetes driven factors including hyperinsulinemia, insulin resistance, hyperglycemia and low grade chronic inflammation are of great importance. Recently, vitamin D deficiency was reported to be associated with the pathogenesis of numerous diseases, including T2DM and cancer. However, little is known whether vitamin D deficiency may be responsible for elevated cancer risk development in T2DM patients. Therefore, the aim of the current review is to identify the molecular mechanisms by which vitamin D deficiency may contribute to cancer development in T2DM patients. Vitamin D via alleviation of insulin resistance, hyperglycemia, oxidative stress and inflammation reduces diabetes driven cancer risk factors. Moreover, vitamin D strengthens the DNA repair process, and regulates apoptosis and autophagy of cancer cells as well as signaling pathways involved in tumorigenesis i.e., tumor growth factor β (TGFβ), insulin-like growth factor (IGF) and Wnt-β-Cathenin. It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Although, numerous studies revealed that adequate vitamin D concentration prevents or delays T2DM and cancer development, little is known how the vitamin affects cancer risk among T2DM patients. There is a pressing need for randomized clinical trials to clarify whether vitamin D deficiency may be a factor responsible for increased risk of cancer in T2DM patients, and whether the use of the vitamin by patients with diabetes and cancer may improve cancer prognosis and metabolic control of diabetes.

scholarly journals Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future

2021 ◽  
Author(s):  
Matthew F Warren ◽  
Kimberly A Livingston
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
The Body ◽  
Human Nutrition ◽  
Vitamin D Metabolites ◽  
Vitamin D Metabolism ◽  
Related Research ◽  
Vitamin D Intake ◽  
Increased Risk

Abstract The risk of vitamin D insufficiency in humans is a global problem that requires improving ways to increase vitamin D intake. Supplements are a primary means for increasing vitamin D intake, but without a clear consensus on what constitutes vitamin D sufficiency, there is toxicity risk with taking supplements. Chickens have been used in many vitamin D-related research studies, especially studies involving vitamin D supplementation. Our state-of-the-art review evaluates vitamin D metabolism and how the different hydroxylated forms are synthesized. We provide an overview with how vitamin D is absorbed, transported, excreted, and what tissues in the body store vitamin D metabolites. We also discuss a number of studies involving vitamin D supplementation with broilers and laying hens. Vitamin D deficiency and toxicity are also described and how they can be caused. The vitamin D receptor (VDR) is important for vitamin D metabolism. However, there is much more that can be understood with VDR in chickens. Potential research aims involving vitamin D and chickens should explore VDR mechanisms which could lead to newer insights with VDR. Utilizing chickens in future research to help with elucidating vitamin D mechanisms has great potential to advance human nutrition. Finding ways to increase vitamin D intake will be necessary because the coronavirus 2019 disease (COVID-19) pandemic is leading to increased risk of vitamin D deficiency in many populations. Chickens can provide a dual purpose with addressing pandemic-caused vitamin D deficiency: 1) vitamin D supplementation gives chickens added value with possibly leading to vitamin D-enriched meat and egg products; and 2) chickens’ use in research provides data for translational research. Expanding vitamin D-related research in chickens to include more nutritional aims in vitamin D status has great implications with developing better strategies to improve human health.

Frontiers in Service Science: Fintech Operations—An Overview of Recent Developments and Future Research Directions

2021 ◽  
Vol 13 (1) ◽  
pp. 19-35
Author(s):  
Baile Lu ◽  
Shuai Hao ◽  
Michael Pinedo ◽  
Yuqian Xu
Keyword(s):  
Future Research ◽  
Algorithmic Trading ◽  
Payment Systems ◽  
Research Directions ◽  
Operational Risks ◽  
Technology Industry ◽  
Recent Developments ◽  
Future Research Directions ◽  
Conclusion Section ◽  
Financial Technology

In this paper, we provide a survey of recent developments in the fintech (financial technology) industry, focusing on the operational structures, the technologies involved, and the operational risks associated with the new systems. In particular, we discuss payment systems, algorithmic trading, robo-advisory, crowdfunding, and peer-to-peer lending. In the conclusion section, we discuss various promising research directions.

Abstract T P146: Vitamin D Deficiency is Associated With Stroke in Black and White Participants of the REGARDS Study

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Suzanne E Judd ◽  
Virginia J Howard ◽  
Paul Muntner ◽  
Brett M Kissela ◽  
Bhupesh Panwar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Racial Differences ◽  
Sex Education ◽  
The United States ◽  
Dietary Vitamin ◽  
Equal Distribution ◽  
Black And White ◽  
Increased Risk ◽  
Regards Study

Objective: Black Americans are at greater risk of both stroke and vitamin D deficiency than white Americans. We have previously shown that both higher dietary vitamin D and sunlight exposure are associated with decreased risk of stroke; however, serum 25(OH) is thought to be a better marker of vitamin D status. Methods: Using a case cohort design, we examined the association of plasma 25(OH)D with incident stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, a cohort of black and white participants from across the United States enrolled between 2003 and 2007. Medical records were reviewed by physicians and strokes were classified on the basis of symptoms and neuroimaging. Strokes through July 1, 2011 were included. A stratified cohort sample was selected to ensure approximately equal numbers of black and white participants and an equal distribution across ages. We used Cox proportional hazards models weighted back to the original 30,239 participants, excluding those with history of stroke. Serum 25(OH)D was measured by Immunodetection Systems ELISA. Results: Over mean follow-up of 4.4 years, there were 539 ischemic and 71 hemorrhagic strokes. The stroke-free sub-cohort included 939 participants. After adjustment for age, race, sex, education, diabetes, hypertension, smoking, atrial fibrillation, heart disease, physical activity, kidney function, calcium and phosphorous, 25(OH)D level 30 ng/mL. The direction of association was similar for hemorrhagic stroke though not statistically significant (HR=1.59; 95%CI=0.78, 3.24). Vitamin D deficiency was associated with an increased risk of all stroke (HR=1.54; 95%CI=1.05, 2.23). This effect was greater in blacks (HR=2.09; 95%CI=1.09, 3.99) than whites (HR=1.38; 95%CI=0.78, 2.42). Results were not as strong when we modeled 25(OH)D as a continuous variable (HR=0.99 per 1 ng/ml change in 25(OH)D; 95%CI=0.98, 1.01). Discussion: Similar to low vitamin D intake, vitamin D deficiency is a risk factor for incident stroke. These findings support evidence from cardiovascular and cancer epidemiology that treating low 25(OH)D may prevent strokes.

Nonlinear Vibrations of Plates: An Update of Recent Research Developments

1996 ◽  
Vol 49 (10S) ◽  
pp. S55-S62 ◽  
Author(s):  
M. Sathyamoorthy
Keyword(s):  
Nonlinear Vibrations ◽  
Laminated Composite ◽  
Composite Plates ◽  
Future Research ◽  
Research Directions ◽  
Inertia Effects ◽  
Vibration Behavior ◽  
Recent Developments ◽  
Complicating Factors ◽  
Future Research Directions

This paper comprises a survey on the nonlinear vibration analysis of plates, with emphasis on research carried out since 1987. Most of the research reviewed here deals with the effects of geometric nonlinearity on the vibration behavior of plates. Complicating factors such as material nonlinearity, geometric imperfections, transverse shear and rotatory inertia effects, and magnetic fields on the vibration behavior are included. Recent developments in the analytical and numerical methods of solution of isotropic, orthotropic as well as laminated, composite plates are presented. Experimental, analytical, and numerical investigations are included for all the cases reviewed and some general remarks are presented along with suggestions for future research directions.

scholarly journals Vitamin D deficiency and health

2010 ◽  
Vol 16 (3) ◽  
pp. 277-281 ◽  
Author(s):  
I. L. Nikitina ◽  
T. L. Karonova ◽  
E. N. Grineva
Keyword(s):  
Vitamin D ◽  
Clinical Trials ◽  
Vitamin D Deficiency ◽  
Wide Spectrum ◽  
Increased Risk ◽  
High Prevalence

The high prevalence of vitamin D defi ciency worldwide and the associated increased risk for different pathologies require re-evaluation of this problem and its signifi cance. The wide spectrum of the diseases associated with vitamin D defi ciency explains the high scientifi c interest and increasing number of clinical trials in this area, and the involvement of larger populations into studies.

scholarly journals Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation

2017 ◽  
Vol 32 (3) ◽  
pp. 505-513 ◽  
Author(s):  
Young-Jae Park ◽  
Sang-Un Kim ◽  
Kyung-Hee Lee ◽  
Jong-Hak Lee ◽  
Eugene Kwon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Transplantation ◽  
Vitamin D Deficiency ◽  
Bacterial Infections ◽  
Increased Risk

Cardiometabolic conditions could be related to vitamin D deficiency. The genetic determinants that affect vitamin D pathways may be solved with nanomedicines.

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Clinical Practice ◽  
Vitamin D Deficiency ◽  
Genetic Determinants ◽  
Bulk Materials ◽  
Treatment Regimens ◽  
Recent Developments

Vitamin D deficiency is a risk factor for cardiometabolic disorders.Nanomedicines can be used to treat atherosclerosis and associated ischemicdisorders. They are able to reduce internal clearance pathways and prolongblood circulation. They also have a large surface size and more sensitive andvaried reactivity than bulk materials, making them more effective at targetingand functionalizing nanoparticles for various types of disease. This studyfocuses on the specialized use of nanomedicine for atherosclerotic diseases inpreclinical and clinical practice. It presents the most recent developments innanomedicine-based treatment regimens for the disease. It has the potential tosolve the genetic determinants that influence vitamin D pathways.

A Cross-Cultural Review of Workplace Deviance Research

2020 ◽  
pp. 23-46
Author(s):  
Selcen Kılıçaslan Gökoğlu ◽  
Engin Bağış Öztürk
Keyword(s):  
Cultural Differences ◽  
Cross Cultural ◽  
Workplace Deviance ◽  
Future Research ◽  
Moderator Variable ◽  
Negative Behaviors ◽  
Deviant Behaviors ◽  
Cross Cultural Differences ◽  
Recent Developments ◽  
Future Research Directions

In the last two decades, workplace deviance becomes one of the most important topics to understand negative behaviors at work. However, many of the studies that examine deviance take a universal perspective and undermine cross-cultural differences. To address this gap, this chapter focuses on cross-cultural differences and its relationship with deviant workplace behaviors. The authors claim that cross-cultural differences can play an important role as an antecedent and/or moderator variable in influencing deviant behaviors. In order to discuss these effects, they first summarize recent developments in individualism-collectivism, tightness-looseness, and honor cultures. Based on their interpretations, target-oriented deviance might be highly contextualized in collectivist cultures, form of deviance and contents of deviance could be different from honor to dignity cultures. In addition, deviant behaviors as responses to specific events might differ whether a person belongs in a tight culture or not. The implications of our arguments and future research directions are discussed.

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