The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?

2013 ◽  
Vol 91 (6) ◽  
pp. 496-501 ◽  
Author(s):  
Olivia R.L. Wright ◽  
Ingrid J. Hickman ◽  
William G. Petchey ◽  
Clair M. Sullivan ◽  
Cynthia Ong ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Waist Circumference ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Hydroxyvitamin D ◽  
Enhanced Production ◽  
Hmw Adiponectin ◽  
Total Adiponectin ◽  
25 Hydroxyvitamin D

There has been substantial recent interest in using vitamin D to improve insulin sensitivity and preventing/delaying diabetes in those at risk. There is little consensus on the physiological mechanisms and whether the association is direct or indirect through enhanced production of insulin-sensitising chemicals, including adiponectin. We examined cross-sectional associations between serum 25-hydroxyvitamin D (25(OH)D) and insulin sensitivity (Matsuda index), parathyroid hormone (PTH), waist circumference, body mass index (BMI), triglycerides (TG), total and high molecular weight (HMW) adiponectin, HMW : total adiponectin ratio (HMW : total adiponectin), and total cholesterol : HDL cholesterol ratio (TC:HDL cholesterol) in 137 Caucasian adults of mean age 43.3 ± 8.3 years and BMI 38.8 ± 6.9 kg/m2. Total adiponectin (standardised β = 0.446; p < 0.001), waist circumference (standardised β = –0.216; p < 0.05), BMI (standardised β = –0.212; p < 0.05), and age (standardised β = –0.298; p < 0.001) were independently associated with insulin sensitivity. Serum 25(OH)D (standardised β = 0.114; p = 0.164) was not associated with insulin sensitivity, total or HMW adiponectin, HMW : total adiponectin, or lipids. Our results provide the novel finding that 25(OH)D is not associated with HMW adiponectin or HMW : total adiponectin in nondiabetic, obese adults and support the lack of association between 25(OH)D and lipids noted by others in similar groups of patients.

Cardiometabolic Risk Factors in Men with Elevated Macroprolactin Content: A Pilot Study

2019 ◽  
Vol 129 (01) ◽  
pp. 7-13
Author(s):  
Robert Krysiak ◽  
Witold Szkróbka ◽  
Bogusław Okopień
Keyword(s):  
Uric Acid ◽  
Insulin Sensitivity ◽  
Plasma Levels ◽  
Cardiometabolic Risk ◽  
Plasma Lipids ◽  
Plasma Concentrations ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Abstract Background Macroprolactinemia is a condition associated with the presence of large amounts of high molecular weight complexes of prolactin. Despite high prevalence, clinical significance of macroprolactin remains poorly understood. Objective The aim of this study was to assess cardiometabolic risk in men with isolated macroprolactinemia. Methods The study population included 11 men with isolated macroprolactinemia, 14 subjects with monomeric hyperprolactinemia and 14 men with prolactin levels within the reference range. Glucose homeostasis markers, plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine and 25-hydroxyvitamin D were determined in all included patients. Results Compared to healthy counterparts, men with isolated macroprolactinemia had higher levels of 2-h postchallenge glucose, hsCRP and fibrinogen, lower levels of 25-hydroxyvitamin D and reduced insulin sensitivity. Patients with monomeric hyperprolactinemia were characterized by increased plasma levels of 2-h postchallenge glucose, triglycerides, uric acid, hsCRP, fibrinogen and homocysteine, reduced insulin sensitivity and decreased plasma concentrations of HDL cholesterol and 25-hydroxyvitamin D. Subjects with isolated macroprolactinemia differed from patients with monomeric hyperprolactinemia in postchallenge plasma glucose, insulin sensitivity, uric acid, hsCRP, fibrinogen, homocysteine and 25-hydroxyvitamin D. In men with monomeric hyperprolactinemia, uric acid, hsCRP, fibrinogen, homocysteine and 25-hydroxyvitamin D, while in men with elevated levels of macroprolactin, uric acid, hsCRP, fibrinogen and 25-hydroxyvitamin D correlated with a content of monomeric prolactin or macroprolactin, respectively, as well as with a degree of insulin sensitivity. Conclusions The obtained results suggest that macroprolactinemia may increase cardiometabolic risk but to a lesser extent than monomeric hyperprolactinemia.

scholarly journals 25-hydroxyvitamin D, Igf-1, And Waist Circumference A Cross-sectional Study

2015 ◽  
Vol 47 ◽  
pp. 804
Author(s):  
Damon McCune ◽  
Laura Kruskall ◽  
James Navalta ◽  
Richard Tandy ◽  
John Young ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study

2014 ◽  
Vol 133 (2) ◽  
pp. 73-77 ◽  
Author(s):  
Guilherme de Vieira Giorelli ◽  
Lívia Nascimento de Matos ◽  
Amir Saado ◽  
Vera Lúcia Soibelman ◽  
Cristiane Bitencourt Dias
Keyword(s):  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Large For Gestational Age ◽  
Oral Glucose ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Significant Difference ◽  
25 Hydroxyvitamin D

CONTEXT AND OBJECTIVE: Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes. DESIGN AND SETTING: Cross-sectional study at a tertiary hospital. METHODS: Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m2; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic). RESULTS: There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m2). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl). CONCLUSION: There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed.

scholarly journals Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001–2006

2016 ◽  
Vol 20 (10) ◽  
pp. 1797-1806 ◽  
Author(s):  
Susanne Vogt ◽  
Jens Baumert ◽  
Annette Peters ◽  
Barbara Thorand ◽  
Robert Scragg
Keyword(s):  
Waist Circumference ◽  
Total Cholesterol ◽  
Abdominal Obesity ◽  
National Health ◽  
Serum Lipids ◽  
Nutrition Examination Survey ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Health And Nutrition ◽  
25 Hydroxyvitamin D

AbstractObjectiveTo examine the interaction between waist circumference (WC) and serum 25-hydroxyvitamin D (25(OH)D) level in their associations with serum lipids.DesignCross-sectional study. The associations of serum 25(OH)D with total cholesterol, HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), LDL-C:HDL-C and TAG were examined using multiple linear regression. Effect modification by WC was assessed through cross-product interaction terms between 25(OH)D and WC categories (abdominal overweight, 80–<88 cm in females/94–<102 cm in males; abdominal obesity, ≥88 cm in females/≥102 cm in males).SettingThe US National Health and Nutrition Examination Survey waves 2001–2006.SubjectsNon-pregnant fasting participants (n 4342) aged ≥20 years.ResultsLower 25(OH)D levels were significantly associated with lower HDL-C levels as well as with higher LDL-C:HDL-C and TAG levels in abdominally obese participants, but not in abdominally overweight or normal-waist participants. In contrast, lower 25(OH)D levels were associated with lower levels of total cholesterol and LDL-C in abdominally overweight and normal-waist participants only, but this association was only partly significant. However, a significant difference in the association between 25(OH)D and the lipids according to WC category was found only for LDL-C:HDL-C (P for interaction=0·02).ConclusionsOur results from this large, cross-sectional sample suggest that the association between lower 25(OH)D levels and an unfavourable lipid profile is stronger in individuals with abdominal obesity than in those with abdominal overweight or a normal WC.

scholarly journals Serum 25-Hydroxyvitamin D Is Inversely Associated with Monocyte Percentage to HDL Cholesterol Ratio among Young Healthy Adults in Qatar

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 127
Author(s):  
Hanaa Mousa ◽  
Nazmul Islam ◽  
Vijay Ganji ◽  
Susu M. Zughaier
Keyword(s):  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Multivariate Regression Analysis ◽  
Healthy Adults ◽  
Cholesterol Ratio ◽  
Hydroxyvitamin D ◽  
Potential Biomarker ◽  
25 Hydroxyvitamin D ◽  
Altered Lipid

Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12–20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.

scholarly journals Determinants of vitamin D status in young children: results from the Belgian arm of the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) Study

2011 ◽  
Vol 15 (6) ◽  
pp. 1093-1099 ◽  
Author(s):  
Isabelle Sioen ◽  
Theodora Mouratidou ◽  
Jean-Marc Kaufman ◽  
Karin Bammann ◽  
Nathalie Michels ◽  
...  
Keyword(s):  
Vitamin D ◽  
Waist Circumference ◽  
Health Effects ◽  
Linear Regression Analysis ◽  
Skinfold Thickness ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
And Gender

AbstractObjectiveTo describe the vitamin D status of Belgian children and examine the influence of non-nutritional determinants, in particular of anthropometric variables.DesignCross-sectional data of Belgian participants of the EU 6th Framework Programme IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) Study.Setting25-Hydroxyvitamin D (25(OH)D) was measured using RIA. Vitamin D status was categorized as deficient (<25 nmol/l), insufficient (25–50 nmol/l), sufficient (50–75 nmol/l) and optimal (≥75 nmol/l). Anthropometric measurements included height, weight, waist and hip circumferences and triceps and subscapular skinfold thicknesses.SubjectsChildren (n 357) aged 4–11 years.ResultsSerum 25(OH)D ranged from 13·6 to 123·5 nmol/l (mean 47·2 (sd 14·6) nmol/l); with 5 % deficient, 53 % insufficient, 40 % sufficient and 2 % optimal. No significant differences were found by age and gender. Significant differences in 25(OH)D were observed for month of sampling (P < 0·001), number of hours playing outside per week (r = 0·140), weight (r = −0·121), triceps (r = −0·112) and subscapular (r = −0·119) skinfold thickness, sum of two skinfold thicknesses (r = −0·125) and waist circumference (r = −0·108). Linear regression analysis of 25(OH)D adjusted for age, month of sampling and hours playing outside per week suggested that (i) weight, (ii) BMI Z-score, (iii) waist circumference and (iv) triceps and subscapular skinfold thickness (as well as the sum of both) independently influenced 25(OH)D.ConclusionsThe majority of Belgian children had a suboptimal vitamin D status, with more than half having an insufficient status in winter and spring. Month of the year, weekly number of hours playing outside and body composition – both central and abdominal obesity – were identified as important determinants of vitamin D status in Belgian children.

Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

Open Medicine ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. 752-757 ◽  
Author(s):  
Nasser Al-Daghri ◽  
Omar Al-Attas ◽  
Majed Alokail ◽  
Khalid Alkharfy ◽  
Mansour Yousef ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Hypovitaminosis D ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractHypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children

2019 ◽  
Vol 23 (7) ◽  
pp. 1214-1222 ◽  
Author(s):  
Zhi Fu ◽  
Cheng Xu ◽  
Yaqin Shu ◽  
Zongyun Xie ◽  
Changgui Lu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Children And Adolescents ◽  
Hdl Cholesterol ◽  
Black Population ◽  
Metabolic Parameters ◽  
Metabolic Parameter ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Us Children

AbstractObjective:To explore the relationships of serum 25-hydroxyvitamin D (25(OH)D) with obesity and metabolic parameters in US children.Design:Cross-sectional analysis. We evaluated the associations between serum 25(OH)D and multiple measurements of adiposity, serum lipid concentrations, fasting glucose and insulin resistance in children aged 6–18 years with adjustments for multiple covariates.Setting:The National Health and Nutrition Examination Survey, 2001–2006.Participants:A nationally representative sample of 6311 children and adolescents aged 6–18 years.Results:Among US children and adolescents, the prevalence of vitamin D deficiency has been especially high in older children, girls and the non-Hispanic Black population. Higher odds of obesity were found at a 25(OH)D concentration of <30 nmol/l (deficiency) than at >50 nmol/l under both criteria for obesity in children (OR = 3·27, Ptrend ≤ 0.001). Moreover, increased odds of having abnormal HDL-cholesterol (OR = 1·71, Ptrend ≤ 0.001) and impaired insulin resistance (OR = 4·15, Ptrend ≤ 0·001) were found for children deficient in 25(OH)D compared with those with normal 25(OH)D concentrations. When the children and adolescents were stratified by gender, we found stronger associations between serum 25(OH)D concentration and both HDL-cholesterol and insulin resistance in girls. No association of 25(OH)D with any other metabolic parameter was found.Conclusions:Our results suggest a potential harmful association between low serum 25(OH)D concentration and the risk of obesity among children. However, the underlying mechanisms require further investigation.

scholarly journals Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gloria Lena Vega ◽  
Scott M. Grundy
Keyword(s):  
Insulin Sensitivity ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
High Ratio ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Adult Men ◽  
Low Hdl ◽  
Adipose Tissue Triglyceride ◽  
High Triglyceride

Background. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance.Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μg/mL)and high (≥6.5 μg/mL)adiponectin levels or a low or high ratio of adiponectin/leptin.Results. Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR than those with low ratio. In contrast, levels of adiponectin or the ratio of adiponectin/leptin did not associate with systolic blood pressure. But the ratio of adiponectin/leptin decreased progressively with the increase in the number of risk factors for metabolic syndrome.Conclusion. Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. Men with high adiponectin/leptin ratios have better triglyceride profile and insulin sensitivity than men with a low ratio regardless of waist girth.

scholarly journals Vitamin D status of Year 3 children and supplementation through schools with fortified milk

2008 ◽  
Vol 12 (12) ◽  
pp. 2329-2334 ◽  
Author(s):  
David Graham ◽  
Geoff Kira ◽  
John Conaglen ◽  
Stephanie McLennan ◽  
Elaine Rush
Keyword(s):  
Vitamin D ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Control Group ◽  
Normal Range ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Fortified Milk ◽  
25 Hydroxyvitamin D ◽  
Daily Milk

AbstractObjectiveTo evaluate levels of vitamin D3and HDL-cholesterol (HDL-C), and the ratio of HDL-C to LDL-cholesterol (LDL-C), in schoolchildren receiving vitamin-D-fortified, fat-depleted, high-Ca milk in schools.DesignCross-sectional study of previously randomised schools receiving supplemental milk, compared with a matched control group.SettingLow-decile Year 1–6 schools in the Waikato region of New Zealand.SubjectsYear 3 children from either milk schools or control schools, consenting to blood sampling.ResultsFor eighty-nine children receiving supplementary daily milk, vitamin D3levels were significantly higher than in eighty-three control children matched for age, sex, body composition and ethnicity (mean (sd): 49·6 (15·8)v. 43·8 (14·7) nmol/l,P= 0·011), as were HDL-C levels (mean (sd): 1·47 (0·35)v. 1·35 (0·29) mmol/l,P= 0·024) and HDL-C:LDL-C (median: 0·79v. 0·71,P= 0·026). LDL-C levels were similar in both groups (mean (sd): 2·07 (0·55)v. 2·16 (0·60) mmol/l,P= 0·31). Of control children, 32/83 (20·2 %) of the milk group (Pearson’sχ2= 7·00,P= 0·008). Mean 25-hydroxyvitamin D (vitamin D3) levels in the milk group were still below the lower end of the recommended normal range (60 nmol/l).ConclusionsVitamin D3levels are low in low-decile Year 3 children in midwinter. Levels are improved with vitamin-D-fortified milk but still below the recommended range. HDL-C and HDL-C:LDL-C levels are improved in the milk-supplemented group. This supports the supply of vitamin-D-fortified, fat-reduced milk to schools.

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