ENZYME INHIBITION BY DERIVATIVES OF PHENOTHIAZINE

1952 ◽  
Vol 30 (6) ◽  
pp. 549-551
Author(s):  
G. M. Allenby ◽  
H. B. Collier
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Enzyme Inhibition ◽  
Anthelmintic Activity ◽  
Hexokinase Activity ◽  
Relationship Of ◽  
Derivatives Of ◽  
Rat Brain Tissue

Rat-brain tissue was homogenized in the presence of fluoride to depress apyrase, and hexokinase activity of the homogenate was measured manometrically. Phenothiazone was found to be a powerful inhibitor of hexokinase, with 50% inhibition at about 7 × 10−6 M concentration. The possible relationship of this finding to the anthelmintic activity of phenothiazine is discussed.

Liquid Chromatography Analysis of Clozapine in Rat Brain Tissue, Using its Molecularly Imprinted Polymer after Administration of Toxic Dose of Drug and Lipid Emulsion Therapy

2019 ◽  
Vol 15 (3) ◽  
pp. 251-257
Author(s):  
Bahareh Sadat Yousefsani ◽  
Seyed Ahmad Mohajeri ◽  
Mohammad Moshiri ◽  
Hossein Hosseinzadeh
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Molecularly Imprinted Polymer ◽  
Lipid Emulsion ◽  
Limit Of Detection ◽  
Imprinted Polymer ◽  
Toxic Dose ◽  
Molecularly Imprinted ◽  
The Brain ◽  
Rat Brain Tissue

Background:Molecularly imprinted polymers (MIPs) are synthetic polymers that have a selective site for a given analyte, or a group of structurally related compounds, that make them ideal polymers to be used in separation processes.Objective:An optimized molecularly imprinted polymer was selected and applied for selective extraction and analysis of clozapine in rat brain tissue.Methods:A molecularly imprinted solid-phase extraction (MISPE) method was developed for preconcentration and cleanup of clozapine in rat brain samples before HPLC-UV analysis. The extraction and analytical process was calibrated in the range of 0.025-100 ppm. Clozapine recovery in this MISPE process was calculated between 99.40 and 102.96%. The limit of detection (LOD) and the limit of quantification (LOQ) of the assay were 0.003 and 0.025 ppm, respectively. Intra-day precision values for clozapine concentrations of 0.125 and 0.025 ppm were 5.30 and 3.55%, whereas inter-day precision values of these concentrations were 9.23 and 6.15%, respectively. In this study, the effect of lipid emulsion infusion in reducing the brain concentration of drug was also evaluated.Results:The data indicated that calibrated method was successfully applied for the analysis of clozapine in the real rat brain samples after administration of a toxic dose to animal. Finally, the efficacy of lipid emulsion therapy in reducing the brain tissue concentration of clozapine after toxic administration of drug was determined.Conclusion:The proposed MISPE method could be applied in the extraction and preconcentration before HPLC-UV analysis of clozapine in rat brain tissue.

scholarly journals The Biosynthesis of a Disialylganglioside by Galactosyltransferase from Rat Brain Tissue

1972 ◽  
Vol 247 (8) ◽  
pp. 2322-2327
Author(s):  
Frederico A. Cumar ◽  
John F. Tallman ◽  
Roscoe O. Brady
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Rat Brain Tissue

Effects of near-infra-red laser irradiation on adenosine triphosphate and adenosine diphosphate contents of rat brain tissue

2002 ◽  
Vol 323 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Noriko Mochizuki-Oda ◽  
Yosky Kataoka ◽  
Yilong Cui ◽  
Hisao Yamada ◽  
Manabu Heya ◽  
...  
Keyword(s):  
Rat Brain ◽  
Laser Irradiation ◽  
Brain Tissue ◽  
Adenosine Triphosphate ◽  
Adenosine Diphosphate ◽  
Infra Red ◽  
Rat Brain Tissue

CBP-18, a Ca2+-Binding Protein in Rat Brain: Tissue Distribution and Localization

1993 ◽  
Vol 60 (5) ◽  
pp. 1639-1649 ◽  
Author(s):  
H.-P. Lipp ◽  
D. P. Wolfer ◽  
W. X. Qin ◽  
C. B. Klee ◽  
C. W. Heizmann
Keyword(s):  
Tissue Distribution ◽  
Rat Brain ◽  
Brain Tissue ◽  
Binding Protein ◽  
Rat Brain Tissue

MORPHOLOGIC INVESTIGATION OF SUBCHRONIC FORMALDEHYDE INHALATION ON RAT BRAIN TISSUE

2021 ◽  
Vol 77 (11) ◽  
Author(s):  
Rabia Tasdemir ◽  
Tuncay Çolak ◽  
Belgin Bamaç ◽  
Süreyya Ceylan ◽  
Selenay Furat Rençber
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Formaldehyde Inhalation ◽  
Rat Brain Tissue

scholarly journals Highlighting anatomical sub-structures in rat brain tissue using lipid imaging

2011 ◽  
Vol 3 (8) ◽  
pp. 1729 ◽  
Author(s):  
Alice M. Delvolve ◽  
Benoit Colsch ◽  
Amina S. Woods
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Rat Brain Tissue

Large-scale N-glycoproteome map of rat brain tissue: Simultaneous characterization of insoluble and soluble protein fractions

PROTEOMICS ◽  
2011 ◽  
Vol 11 (21) ◽  
pp. 4274-4278 ◽  
Author(s):  
Xiaoqiang Qiao ◽  
Dingyin Tao ◽  
Yanyan Qu ◽  
Liangliang Sun ◽  
Liang Gao ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Soluble Protein ◽  
Large Scale ◽  
Protein Fractions ◽  
Rat Brain Tissue

Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage

1999 ◽  
Vol 379 (1) ◽  
pp. 33-45 ◽  
Author(s):  
Carsten Culmsee ◽  
Ralf K Stumm ◽  
Martin K.-H Schäfer ◽  
Eberhard Weihe ◽  
Josef Krieglstein
Keyword(s):  
Growth Factor ◽  
Rat Brain ◽  
Brain Tissue ◽  
Ischemic Damage ◽  
Rat Brain Tissue
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