scholarly journals Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers

2017 ◽  
Vol 95 (9) ◽  
pp. 954-964 ◽  
Author(s):  
Mario Ficker ◽  
Valentina Paolucci ◽  
Jørn B. Christensen
Keyword(s):  
Ir Spectroscopy ◽  
Biomedical Applications ◽  
Large Scale ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
Synthesis And Characterization ◽  
Preclinical Testing ◽  
Laboratory Science ◽  
Gmp Production

Dendrimers are promising polymers for biomedical applications; however, most dendrimer formulations have failed to move from laboratory science to upscaled products for preclinical testing or GMP production. This publications reports on an improved large-scale PAMAM dendrimer synthesis that is suitable to manufacture large amounts of highly pure and monodisperse dendrimers of generations G0–G5. Furthermore, an extended analytical guideline how to characterize PAMAM dendrimers with NMR, HPLC, SEC-MALS, ESI, MALDI, UV–vis, fluorescence, and IR spectroscopy is provided.

Synthesis and Characterization of Ferrocenyl Carboxilic Surface-Functionalized Resorcinaren-PAMAM Dendrimers

2015 ◽  
Vol 19 (19) ◽  
pp. 1954-1960 ◽  
Author(s):  
Sandra Cortez-Maya ◽  
Elena Klimova ◽  
R. I. Puente Lee ◽  
Andres Borja-Miranda ◽  
Marcos Martinez-Garcia
Keyword(s):  
Pamam Dendrimers ◽  
Synthesis And Characterization

scholarly journals Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9076-9085
Author(s):  
Kanchan Yadav ◽  
Megha Das ◽  
Nurul Hassan ◽  
Archana Mishra ◽  
Jayeeta Lahiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Live Cell Imaging ◽  
Biomedical Applications ◽  
Breast Cancer Cells ◽  
Cell Imaging ◽  
Synthesis And Characterization ◽  
Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

scholarly journals Synthesis and characterization of nanostructured ceramics powders for biomedical applications

2007 ◽  
Vol 12 (4) ◽  
pp. 574-582 ◽  
Author(s):  
Nelson Heriberto de Almeida Camargo ◽  
O. J. Bellini ◽  
Enori Gemelli ◽  
M. Tomiyama
Keyword(s):  
Calcium Phosphate ◽  
Nanostructured Materials ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Morphological Characterization ◽  
Synthesis And Characterization ◽  
Powder Synthesis ◽  
Mineralogical Characteristics ◽  
Nanostructured Ceramics

Nanostructured materials have been largely studied in the last few years because they have a great potential to applications in different fields like physics, chemistry, biology, mechanic and medicine. Synthesis and characterization of nanostructured materials is a subject of great interest involving science, market, politicians, government and society. The nanostructured materials are in demand in biomedical area, mainly the bioceramics composed of calcium phosphates (Ca/P), which have an excellent biocompatibility and mineralogical characteristics similar to those of bones. The aim of this work was to optimize the method of powder synthesis of nanostructured calcium phosphate and of nanocomposites composed of calcium phosphate//SiO2n, containing 5, 10 and 15% (in volume) of nanometric silica (SiO2n). The results are expressed according to the method of synthesis, mineralogical and morphological characterization, and thermal behavior for the different compositions of the nanostructured powder synthesized.

Electrochemically Synthesis and Characterization of Copolymers Based on 1, 4-Diethoxybenzene and 3, 4-Ethylenedioxythiophene

2011 ◽  
Vol 335-336 ◽  
pp. 989-993
Author(s):  
Mi Ouyang ◽  
Zhen Wei Yu ◽  
Yi Xu ◽  
Yu Jian Zhang ◽  
Cheng Zhang
Keyword(s):  
Cyclic Voltammetry ◽  
Ir Spectroscopy ◽  
Feed Ratio ◽  
Synthesis And Characterization ◽  
Monomer Mixture ◽  
Long Wavelength ◽  
H Nmr ◽  
Ft Ir ◽  
Ft Ir Spectroscopy

Copolymers based on 1, 4-diethoxybenzene (DEB) and 3, 4-ethylenedioxythiophene (EDOT) were electrochemically synthesized and characterized. The structures of the copolymers were established by 1H NMR and FT-IR spectroscopy. The results indicated the final product was a copolymer instead of a blend or a composite. The physical properties were systematically investigated by cyclic voltammetry, UV-vis absorption and fluorescence. The PL maximum of copolymers presented obviously red-shift to long wavelength as the feed ratio of EDOT in monomer mixture increased.

Synthesis and characterization of carboxymethyl dextran-coated Mn/Zn ferrite for biomedical applications

2009 ◽  
Vol 321 (19) ◽  
pp. 3061-3066 ◽  
Author(s):  
Magda Latorre-Esteves ◽  
Angel Cortés ◽  
Madeline Torres-Lugo ◽  
Carlos Rinaldi
Keyword(s):  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Zn Ferrite ◽  
Carboxymethyl Dextran

Synthesis and characterization of a new photo-crosslinkable glycol chitosan thermogel for biomedical applications

2016 ◽  
Vol 144 ◽  
pp. 59-67 ◽  
Author(s):  
Ik Sung Cho ◽  
Myeong Ok Cho ◽  
Zhengzheng Li ◽  
Md Nurunnabi ◽  
Sung Young Park ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Glycol Chitosan
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