scholarly journals Effects of polymer intercalation in calcium silicate hydrates on drug loading capacities and drug release kinetics: an X-ray absorption near edge structure study

2017 ◽  
Vol 95 (11) ◽  
pp. 1122-1129 ◽  
Author(s):  
Xiaoxuan Guo ◽  
Jin Wu ◽  
Yun-Mui Yiu ◽  
Yongfeng Hu ◽  
Ying-Jie Zhu ◽  
...  
Keyword(s):  
Drug Release ◽  
Calcium Silicate ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Precipitation Reaction ◽  
Edge Structure ◽  
X Ray ◽  
Drug Release Kinetics ◽  
X Ray Absorption

Different calcium silicate hydrate (CSH)/polymer composites are synthesized by using a controlled precipitation reaction between calcium salt and silicate salt, followed by the addition of various polymer solutions at room temperature. X-ray absorption near edge structure (XANES) spectroscopy has been used to extensively investigate the structural changes after hybrid biomaterials formation and the drug–carrier interactions on the molecular level. We find that the polymers alter the structure of CSH to various degrees and that this behaviour further influences the drug loading capacities and drug release kinetics.

Evaluation of drug release kinetics and physico-chemical characteristics of metronidazole floating beads based on calcium silicate and gas-forming agents

2009 ◽  
Vol 00 (00) ◽  
pp. 090820053614029-10 ◽  
Author(s):  
Yousef Javadzadeh ◽  
Sanaz Hamedeyazdan ◽  
Khosro Adibkia ◽  
Farhad Kiafar ◽  
Mohammad Hosein Zarrintan ◽  
...  
Keyword(s):  
Drug Release ◽  
Calcium Silicate ◽  
Release Kinetics ◽  
Chemical Characteristics ◽  
Drug Release Kinetics ◽  
Physico Chemical

PLGA Nanoparticles for Anti Tuberculosis Drug Delivery

2012 ◽  
Vol 584 ◽  
pp. 465-469 ◽  
Author(s):  
S. Malathi ◽  
S. Balasubramanian
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Loading ◽  
Double Emulsion ◽  
Plga Nanoparticles ◽  
Release Mechanism ◽  
Sustained Drug Release ◽  
Drug Release Kinetics ◽  
Evaporation Technique

Nanoparticles-based drug delivery systems have considerable potential for the treatment of tuberculosis (TB). A series of PLGA polymers with different molar feed ratios (P2:87/13, P3:83/17, P5:63/37, P6:76/24, P9:53/47) were synthesized by direct melt poly condensation method. The resulting biodegradable polymers were characterized by FTIR and 1H NMR spectroscopy. The preparation of the drug (Pyrazinamide (PZA)) encapsulated PLGA polymers were carried out by double emulsion – solvent evaporation technique. The drug loaded PLGA-NPs were analyzed by UV-visible spectroscopy and scanning electron microscopy. The drug loading efficiency and drug release kinetics varies in the following order: P9>P5>P6>P3>P2. Among the formulations, PP9 showed a uniform as well as sustained drug release. The drug release kinetics has been evaluated by Zero-order, First order, Higuchi and Koresmeyer- Peppas models and the release mechanism has also been investigated

scholarly journals Improvement of Drug Release and Compatibility between Hydrophilic Drugs and Hydrophobic Nanofibrous Composites

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5344
Author(s):  
Hazim J. Haroosh ◽  
Yu Dong ◽  
Shaimaa Jasim ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Halloysite Nanotubes ◽  
Polymer Processing ◽  
Hydrophilic Drugs ◽  
Drug Release Kinetics ◽  
Flexible Polymer ◽  
The Impact

Electrospinning is a flexible polymer processing method to produce nanofibres, which can be applied in the biomedical field. The current study aims to develop new electrospun hybrid nanocomposite systems to benefit the sustained release of hydrophilic drugs with hydrophobic polymers. In particular, electrospun hybrid materials consisting of polylactic acid (PLA):poly(ε-caprolactone) (PCL) blends, as well as PLA:PCL/halloysite nanotubes-3-aminopropyltriethoxysilane (HNT-ASP) nanocomposites were developed in order to achieve sustained release of hydrophilic drug tetracycline hydrochloride (TCH) using hydrophobic PLA:PCL nanocomposite membranes as a drug carrier. The impact of interaction between two commonly used drugs, namely TCH and indomethacin (IMC) and PLA:PCL blends on the drug release was examined. The drug release kinetics by fitting the experimental release data with five mathematical models for drug delivery were clearly demonstrated. The average nanofiber diameters were found to be significantly reduced when increasing the TCH concentration due to increasing solution electrical conductivity in contrast to the presence of IMC. The addition of both TCH and IMC drugs to PLA:PCL blends reduced the crystallinity level, glass transition temperature (Tg) and melting temperature (Tm) of PCL within the blends. The decrease in drug release and the impairment elimination for the interaction between polymer blends and drugs was accomplished by mobilising TCH into HNT-ASP for their embedding effect into PLA:PCL nanofibres. The typical characteristic was clearly identified with excellent agreement between our experimental data obtained and Ritger–Peppas model and Zeng model in drug release kinetics. The biodegradation behaviour of nanofibre membranes indicated the effective incorporation of TCH onto HNT-ASP.

scholarly journals Drug release kinetics and biological properties of a novel local drug carrier system

2021 ◽  
Vol 18 (1) ◽  
pp. 94
Author(s):  
Mehrsima Ghavami-Lahiji ◽  
Farhad Shafiei ◽  
TaherehSadat Jafarzadeh Kashi ◽  
Farhood Najafi
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Biological Properties ◽  
Carrier System ◽  
Drug Release Kinetics ◽  
Drug Carrier System

Evaluation of drug release kinetics and physico-chemical characteristics of metronidazole floating beads based on calcium silicate and gas-forming agents

2010 ◽  
Vol 15 (4) ◽  
pp. 329-338 ◽  
Author(s):  
Yousef Javadzadeh ◽  
Sanaz Hamedeyazdan ◽  
Khosro Adibkia ◽  
Farhad Kiafar ◽  
Mohammad Hosein Zarrintan ◽  
...  
Keyword(s):  
Drug Release ◽  
Calcium Silicate ◽  
Release Kinetics ◽  
Chemical Characteristics ◽  
Drug Release Kinetics ◽  
Physico Chemical

The Structure and Release Kinetics of Ca–Al Layered Double Hydroxide by Intercalating with Diclofenac Sodium

NANO ◽  
2020 ◽  
Vol 15 (03) ◽  
pp. 2050028
Author(s):  
Yingying Ma ◽  
Shuhua Zhang ◽  
Yu Wang ◽  
Zhenlin Jiang ◽  
Nengshuo Fu ◽  
...  
Keyword(s):  
Side Effects ◽  
Layered Double Hydroxide ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Diclofenac Sodium ◽  
Basal Spacing ◽  
Release Kinetic ◽  
Edge Structure ◽  
X Ray ◽  
Double Hydroxide

Diclofenac sodium (DS) is an aryl acetic acid nonsteroidal anti-inflammatory drug which is widely used in various types of chronic bone and joint pains, but its terminal plasma half life is short, often accompanied with gastrointestinal side effects. We try to find an inexpensive and effective drug carrier to prolong the administration interval, maintain a stable blood concentration and reduce side effects. In our work, DS had been intercalated into a layered inorganic host, Ca–Al layered double hydroxide (LDH) by co-precipitation under a nitrogen atmosphere to control the release. X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and transmission electron microscope (TEM) were used to investigate the change of chemical structure and morphological structure when DS was inserted into the interlayer of LDH. X-ray photoelectron spectroscopy (XPS) and X-ray absorption near edge structure (XANES) were employed to characterize the electron binding energy of calcium and aluminum cations both on the surface and in the bulk of the samples. The results of absorption peaks, morphologies and the basal spacing increased from 8.6[Formula: see text]Å to 29.59[Formula: see text]Å gave the evidences for the intercalation of DS into the interlayer of CaAl-LDH. The results of XPS and XANES spectra revealed the complexation of –OH and [Formula: see text] with Ca[Formula: see text] and Al[Formula: see text] were both were affected by the loading of DS with CaAl-LDH, but no new chemical bonds were formed. Inductively coupled plasma optical emission spectroscopy (ICP-OES) analysis showed the dissolving process of Ca and Al ions from CaAl-LDH in the solution. In addition, the results of the drug release profile and release kinetic of intercalated LDHs showed that release behavior of DS from intercalated compounds was well controlled.

Tracking Drug Loading Capacities of Calcium Silicate Hydrate Carrier: A Comparative X-ray Absorption Near Edge Structures Study

2015 ◽  
Vol 119 (31) ◽  
pp. 10052-10059 ◽  
Author(s):  
Xiaoxuan Guo ◽  
Zhiqiang Wang ◽  
Jin Wu ◽  
Yun-Mui Yiu ◽  
Yongfeng Hu ◽  
...  
Keyword(s):  
Calcium Silicate ◽  
Calcium Silicate Hydrate ◽  
Drug Loading ◽  
X Ray ◽  
X Ray Absorption
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