scholarly journals Synthesis, characterization, and anticancer properties of organometallic Schiff base platinum complexes

2015 ◽  
Vol 93 (10) ◽  
pp. 1140-1146 ◽  
Author(s):  
Stéphanie Jean ◽  
Kevin Cormier ◽  
Alyssa E. Patterson ◽  
Christopher M. Vogels ◽  
Andreas Decken ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Bond Cleavage ◽  
Cancer Cell Line ◽  
Platinum Complexes ◽  
Hydroxyl Group ◽  
Aliphatic Chain ◽  
X Ray Diffraction ◽  
Anticancer Properties ◽  
Chloride Ligand

A small family of organometallic platinum complexes containing a chloride, cis-cyclooctene, and a Schiff base ligand have been prepared and characterized fully. Three aliphatic amines and four aromatic amines were chosen as representative examples. All complexes were stable in air except for 7, derived from the pinacol-protected 4-aminophenylboronate ester 4-H2NC6H4Bpin (pin = 1,2-O2C2Me4), which decomposed via B–C bond cleavage. Both complexes 4 (derived from aniline) and 7 were further characterized by single-crystal X-ray diffraction studies and confirmed the square planar nature of the platinum centre whereby the chloride ligand lies trans to the deprotonated hydroxyl group of the Schiff base ligand. The imine functionality is trans to the organic cyclooctene group. Complex 3, which contained the longest aliphatic chain studied (an octyl group), was the most promising for inducing apoptosis in the malignant MB231 breast cancer cell line. Conversely, complexes 4–6, which contained aromatic groups, were the most active against renal cell carcinoma (RCC) cell lines.

Synthesis of an Unprecedented H-stitched Binuclear Crystal Structure Based on Selective Fluorescence Recognition of Zn2+ in Newly Synthesized Schiff Base Ligand with DFT and Imaging Application in Living Cells

2021 ◽  
Author(s):  
SOUMYA SUNDAR MATI ◽  
Dr. SAUGATA KONAR ◽  
BOBY SAMAI
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Binuclear Complex ◽  
Living Cells ◽  
X Ray Diffraction ◽  
Schiff Base Ligands ◽  
X Ray ◽  
Imaging Application

A zinc coordinated rare binuclear complex was synthesised and characterized by elemental analysis and single-crystal X-ray diffraction. Two mononuclear units formed by two Schiff base ligands 2-((2-(pyrimidin-2-yl)hydrazono)methyl)phenol (PHP) coordinated with...

Cyclometalated Pt(ii) complexes with a bidentate Schiff-base ligand displaying unexpected cis/trans isomerism: synthesis, structures and electronic properties

2017 ◽  
Vol 46 (37) ◽  
pp. 12500-12506 ◽  
Author(s):  
A. Poma ◽  
A. Forni ◽  
C. Baldoli ◽  
P. R. Mussini ◽  
A. Bossi
Keyword(s):  
Schiff Base ◽  
Electronic Properties ◽  
Computational Methods ◽  
Schiff Base Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
Bidentate Schiff Base Ligand

Unexpected cis/trans isomerism in a bis-cyclometalated Pt(ii) complex is investigated by NMR, X-ray diffraction, optical, electrochemical and computational methods and rationalized.

Anti-mycobacterial activities of copper(II) salicylaldimine complexes derived from long-chain aliphatic amines

2013 ◽  
Vol 91 (11) ◽  
pp. 1093-1097 ◽  
Author(s):  
Alyssa E. Patterson ◽  
Eric G. Bowes ◽  
Allyson Bos ◽  
Taryn O’Neill ◽  
Haoxin Li ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Schiff Base ◽  
Aliphatic Amines ◽  
Schiff Base Complexes ◽  
Aliphatic Chain ◽  
X Ray Diffraction ◽  
X Ray ◽  
Microwave Assisted ◽  
Long Chain

Twelve copper(II) Schiff base complexes derived from lipophilic amines have been prepared using either salicylaldehyde or ortho-vanillin via a microwave-assisted reaction. All complexes have been obtained elementally pure and an X-ray diffraction of an isopentyl derivative has confirmed the structure of these compounds. All complexes showed a promising degree of anti-mycobacterial activity against Mycobacterium tuberculosis, where activity seemed to increase with an increase in the length of the aliphatic chain.

Platinum(II) complex with 4-nitro-N-(pyridin-2-ylmethylidene)aniline: synthesis, characterization, crystal structure and antioxidant activity

2020 ◽  
Vol 76 (11) ◽  
pp. 1005-1009
Author(s):  
Mehdi Khalaj ◽  
Abolfazl Olyaei ◽  
Mahdieh Sadeghpour ◽  
Arash Lalegani ◽  
Janusz Lipkowski ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Antioxidant Activity ◽  
Schiff Base ◽  
Schiff Base Ligand ◽  
Chain Structure ◽  
X Ray Diffraction ◽  
X Ray ◽  
Square Planar ◽  
Dpph Method ◽  
Bidentate Schiff Base Ligand

A novel complex has been prepared using the (E)-4-nitro-N-(pyridin-2-ylmethylidene)aniline bidentate Schiff base ligand and PtCl2, namely, dichlorido[(E)-4-nitro-N-(pyridin-2-ylmethylidene)aniline-κ2 N,N′]platinum(II) acetonitrile hemisolvate, [PtCl2(C12H9N3O2)]·0.5CH3CN, 1. According to the X-ray measurements of the crystal structure, the PtII ion adopts a PtCl2N2 square-planar coordination. The coordination of the Schiff base ligand to the PtII ion occurs in a cyclic bidentate fashion, as a result of which a five-membered metallacycle is formed. Furthermore, in the structure of 1, the neutral molecules form a one-dimensional chain structure through C—H...Cl and C—H...O hydrogen bonds. The characterization of the complex was performed via single-crystal X-ray diffraction, IR spectroscopy and elemental analysis, and the antioxidant activity of the complex was evaluated using spectrophotometry by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method.

Synthesis, crystal structures and characterizations of two homochiral coordination polymers based on a chiral reduced Schiff base ligand

2014 ◽  
Vol 70 (4) ◽  
pp. 375-378 ◽  
Author(s):  
Shao-Ming Ying ◽  
Xiao-Hui Huang ◽  
Wu-Kui Luo ◽  
Yan-Chun Xiao
Keyword(s):  
Schiff Base ◽  
Coordination Polymers ◽  
Schiff Base Ligand ◽  
Three Dimensional ◽  
X Ray Diffraction ◽  
Strong Emission ◽  
X Ray ◽  
Dimensional Network ◽  
Elemental Analyses ◽  
Reduced Schiff Base

Two homochiral coordination polymers based on a chiral reduced Schiff base ligand, namely poly[(μ5-4-{[(NR,1S)-(1-carboxylato-2-phenylethyl)amino]methyl}benzoato)zinc(II)], [Zn(C17H15NO4)]n, (1), and poly[(μ5-4-{[(NR,1S)-(1-carboxylato-2-phenylethyl)amino]methyl}benzoato)cobalt(II)], [Co(C17H15NO4)]n, (2), have been obtained by hydrothermal methods and studied by single-crystal X-ray diffraction, elemental analyses, powder X-ray diffraction, thermogravimetric analysis, IR spectroscopy and fluorescence spectroscopy. Compounds (1) and (2) are isostructural and crystallize in theP212121space group. Both display a three-dimensional network structure with a one-dimensional channel, with the benzyl group of the ligand directed towards the channel. An investigation of photoluminescence properties shows that compound (1) displays a strong emission in the purple region.

scholarly journals Crystal structures of the bis-bidentate N2S2 Schiff base ligand and its copper(I) coordination polymer

2019 ◽  
Vol 38 (2) ◽  
pp. 207
Author(s):  
Aliakbar Dehno Khalaji ◽  
Seyyed Javad Peyghoun ◽  
Michal Dusek ◽  
Monika Kucerakova ◽  
Alireza Akbari ◽  
...  
Keyword(s):  
Schiff Base ◽  
Coordination Polymer ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Bidentate Ligand ◽  
X Ray Diffraction ◽  
Trans Conformation ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Anti Form

A new flexible bis-bidentate N2S2 Schiff base ligand (2,4-Cl-ba)2dapte = N,Nʹ-bis-(2,4-dichlorobenzaldehyde)-1,2-di(o-iminophenylthio)ethane and its copper(I) coordination polymer [Cu2(μ-I)2(μ-(2,4-Cl-ba)2dapte)]n, were synthesized and characterized by CHN elemental analysis, FT-IR and UV-Vis spectroscopy and single-crystal X-ray diffraction. The molecule of (2,4-Cl-ba)2dapte adopts a trans conformation of the 1,2-di(o-iminophenylthio)ethane unit. The (2,4-Cl-ba)2dapte acts as a bis-bidentate ligand with two iminic nitrogen and two sulfur atoms, coordinating to copper(I) ions in an anti-form leading to the dinuclear Cu2(μ-(2,4-Cl-ba)2dapte) groups. These groups are then bridged by two iodide anions to form a copper(I) coordination polymer [Cu2(μ-I)2(μ-(2,4-Cl-ba)2dapte)]n. The coordination geometry around the copper(I) ions is a distorted tetrahedron. Finally, a nano-sized form of the copper(I) coordination polymer [Cu2(μ-I)2(μ-(2,4-Cl-ba)2dapte)]n was prepared by an ultrasonic bath assisted process and characterized by elemental analysis, FT-IR and SEM.

Large interaction energy for the homodimer and the heterodimer extracted from the supramolecular chain of a bent trinuclear zinc(II) complex with a reduced Schiff base ligand

2022 ◽  
Author(s):  
Mainak Karmakar ◽  
Rosa M. Gomila ◽  
Antonio Frontera ◽  
Shouvik Chattopadhyay
Keyword(s):  
Schiff Base ◽  
Diffraction Analysis ◽  
Schiff Base Ligand ◽  
Zinc Complex ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
Amino Groups ◽  
X Ray ◽  
Reduced Schiff Base ◽  
Large Interaction

A bent trinuclear zinc complex, [Zn{ZnIL}2]•DMF {H2L = 2,2'-[(2,2-Dimethyl-1,3-propanediyl)bis(iminomethylene)]bis[6-methoxyphenol]} was synthesized and characterized by standard spectroscopic methods and X-ray diffraction analysis. The existence of coordinated amino groups and iodide counter...

Syntheses and Structure Investigations of 3d Transition Metal Complexes with a Flexible N4O2-Donor Hexadentate Schiff-Base Ligand

2017 ◽  
Vol 70 (5) ◽  
pp. 581 ◽  
Author(s):  
Kyle J. Howard-Smith ◽  
Alexander R. Craze ◽  
Mohan Badbhade ◽  
Christopher E. Marjo ◽  
Timothy D. Murphy ◽  
...  
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
High Resolution Mass Spectrometry ◽  
Molecular Structures ◽  
X Ray Diffraction ◽  
X Ray ◽  
Structure Investigations

The syntheses and structure investigations of four new 3d transition metal complexes (1–4) with a flexible N4O2-donor hexadentate Schiff-base ligand are described; three complexes (1, 2, and 4) of FeIII, CoIII, and CuII metal ions have been investigated by UV-vis, FT-IR, high-resolution mass spectrometry (HR-MS), and scanning electron microscopy–electron dispersive spectroscopy, as well as single crystal X-ray diffraction. The X-ray structure of NiII complex 3 is also reported. The molecular structures of the complexes (1–3) demonstrate distorted octahedral coordination geometry, each exhibiting 1 : 1 (M : L) ratios and the CuII complex 4 shows a trinuclear structure with a CuII : L ratio of 3 : 2 in the solid state, which has been proven by X-ray diffraction. On the other hand, a mononuclear species of the CuII complex is formed in solution, which has been identified by electrospray ionization HR-MS.

Crystal Structure of a Binuclear Copper(II) Complex with μ-Alkoxo and μ-Pyridonato Bridges. Effect of the Dihedral Angle on the Superexchange Interaction

1989 ◽  
Vol 44 (3) ◽  
pp. 307-311 ◽  
Author(s):  
Yuzo Nishida ◽  
Miyuki Masumoto ◽  
Yutaka Mori
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Dihedral Angle ◽  
Schiff Base Ligand ◽  
Superexchange Interaction ◽  
X Ray Diffraction ◽  
Binuclear Copper ◽  
Ferromagnetic Interaction ◽  
X Ray

The crystal structure of the binuclear copper(II) complex. [Cu2(L)(2-pyridonato)] was determined by X-ray diffraction, where H3(L) represents the Schiff base ligand derived from 1,3-diaminopropane-2-ol and acetylacetone. Two copper(II) ions are bridged by alkoxide and 2-pyridonate groups with a Cu-Cu separation of 3.249(2) Å . Ferromagnetic interaction is found to be operating in this complex, which is attributed to the small dihedral angle (121°) between the two planes containing the copper(II) ion.

Sign in / Sign up

Export Citation Format

Share Document