Cucurbit[7]uril host−guest complexations of steroidal neuromuscular blocking agents in aqueous solution

2014 ◽  
Vol 92 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Mona A. Gamal-Eldin ◽  
Donal H. Macartney
Keyword(s):  
Aqueous Solution ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
Host Molecule ◽  
Reversal Agent ◽  
H Nmr ◽  
Blocking Agents ◽  
Dipole Interactions ◽  
Neuromuscular Blockade Reversal ◽  
Esi Mass Spectrometry

The complexations of three steroidal neuromuscular blocking agents, rocuronium, vecuronium, and pancuronium, by the cucurbit[7]uril host molecule have been investigated in aqueous solution using 1H NMR spectroscopy and ESI mass spectrometry. The CB[7] binds to each of the two terminal cationic N-heterocyclic groups by means of ion-dipole interactions and hydrophobic effects, with stability constants in the order of vecuronium > pancuronium > rocuronium. This trend is different from those observed for the anionic substituted γ-cyclodextrin (Sugammadex), currently employed as a neuromuscular blockade reversal agent, and an acylic glycoluril tetramer (Calabadion), recently reported to reverse both steroidal and benzylisoquinolium neuromuscular blocking agents in rats.

scholarly journals Template-Directed Synthesis of Bivalent, Broad-Spectrum Hosts for Neuromuscular Blocking Agents

2021 ◽  
Author(s):  
Allison J. Selinger ◽  
Natalie A. Cavallin ◽  
Fraser Hof
Keyword(s):  
Aqueous Solution ◽  
Broad Spectrum ◽  
High Selectivity ◽  
Building Blocks ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
Water Soluble ◽  
Blocking Agents ◽  
Directed Synthesis

We report on the synthesis of bivalent water soluble calix[4]arene and calix[5]arene hosts, Super-sCx4 and Super-sCx5 as new broad-spectrum supramolecular binders of neuromuscular blocking agents (NMBAs). Synthesis was achieved using the target bisquaternary amine NMBAs as a template to link two highly anionic p-sulfonatocalixarene building blocks in aqueous solution. Bivalent anionic hosts Super-sCx4 and Super-sCx5 bind by engaging both quaternary amines present on a variety of NMBAs. We report low μM binding to structurally diverse alkyl, steroidal, curarine and benzylisoquinoline NMBAs with high selectivity over the neurotransmitter acetylcholine.

scholarly journals Host-Guest Complexations of Amine Boranes and Isoelectronic/Isostructural Quaternary Alkylammonium Cations by Cucurbit[7]uril in Aqueous Solution

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Mona A. Gamal-Eldin ◽  
Donal H. Macartney
Keyword(s):  
Aqueous Solution ◽  
Hydrophobic Effect ◽  
Host Molecule ◽  
Guest Complex ◽  
H Nmr ◽  
Hydrophobic Cavity ◽  
Host Guest Complex ◽  
Dipole Interactions ◽  
The Stability ◽  
Amine Boranes

The host-guest complexation of six amine boranes (R3NBH3) by the macrocyclic host molecule cucurbit[7]uril (CB[7]) in aqueous solution has been investigated using 1H and 11B NMR spectroscopy. The limiting complexation-induced 1H and 11B chemical shift changes indicate that the amine boranes are included in the hydrophobic cavity of the host molecule. The host-guest stability constants for neutral  R3NBH3∙CB[7]  complexes (in the range of 105-107M-1) have been determined by 1H NMR competition experiments and are compared with the corresponding values for the isoelectronic/isostructural  R3NCH3∙CB[7] + complexes. Ammonia borane (H3NBH3) does not form a host-guest complex with CB[7]. The trends in the host-guest stability constant with the guest molar volume are examined, and the stability is ascribed to the hydrophobic effect (packing coefficient) and quadrupole-dipole interactions.

scholarly journals Dosing of neuromuscular blocking agents in patients with obesity: A narrative review

2021 ◽  
pp. 0310057X2096857
Author(s):  
Brian L Erstad ◽  
Jeffrey F Barletta
Keyword(s):  
Body Weight ◽  
Ideal Body Weight ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
Patient Specific ◽  
Lean Body Weight ◽  
Short Term ◽  
Blocking Agents ◽  
Ideal Body ◽  
Size Descriptor

There is no consensus on which weight clinicians should use for weight-based dosing of neuromuscular blocking agents (NMBAs), as exemplified by differing or absent recommendations in clinical practice guidelines. The purpose of this paper is to review studies that evaluated various size descriptors for weight-based dosing of succinylcholine and non-depolarising NMBAs, and to provide recommendations for the descriptors of choice for the weight-based dosing of these agents in patients with obesity. All of the studies conducted to date involving depolarising and non-depolarising NMBAs in patients with obesity have assessed single doses or short-term infusions conducted in perioperative settings. Recognising that any final dosing regimen must take into account patient-specific considerations, the available evidence suggests that actual body weight is the size descriptor of choice for weight-based dosing of succinylcholine and that ideal body weight, or an adjusted (or lean) body weight, is the size descriptor of choice for weight-based dosing of non-depolarising NMBAs.

Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine

2009 ◽  
Vol 24 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Cynthia A. Lien ◽  
Peter Savard ◽  
Matthew Belmont ◽  
Hiorshi Sunaga ◽  
John J. Savarese
Keyword(s):  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
Blocking Agents

SOME NSN-TRIS-QUATERNARY NEUROMUSCULAR BLOCKING AGENTS*

1957 ◽  
Vol 9 (1) ◽  
pp. 1004-1016 ◽  
Author(s):  
D. Edwards ◽  
J. J. Lewis ◽  
J. B. Stenlake ◽  
M. S. Zoha
Keyword(s):  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
Blocking Agents
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