Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands — A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

2013 ◽  
Vol 91 (3) ◽  
pp. 211-219 ◽  
Author(s):  
Adam A.H. Elmehriki ◽  
Mark Milne ◽  
Mojmír Suchý ◽  
Robert Bartha ◽  
Robert H.E. Hudson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chemical Exchange ◽  
Acid Amide ◽  
Mri Contrast Agents ◽  
Chemical Exchange Saturation Transfer ◽  
Tetraacetic Acid ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy3+, Tb3+, and Tm3+) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with corresponding N-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37 °C, revealing that Tm3+-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.

Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2687-2690 ◽  
Author(s):  
Dario Livio Longo ◽  
Enza Di Gregorio ◽  
Riccardo Abategiovanni ◽  
Alberto Ceccon ◽  
Michael Assfalg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lipid Membranes ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Efficient Tool ◽  
Molecular Information ◽  
Magnetic Resonance Imaging Mri

In this communication, we report that protein remodeling processes, such as aggregation, unfolding and interaction with lipid membranes, may be investigated by magnetic resonance imaging (MRI) through the CEST mechanism.

Spin crossover iron(ii) complexes as PARACEST MRI thermometers

2014 ◽  
Vol 5 (6) ◽  
pp. 2461-2465 ◽  
Author(s):  
Ie-Rang Jeon ◽  
Jesse G. Park ◽  
Chad R. Haney ◽  
T. David Harris
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spin Crossover ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Potential Utility ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Temperature Responsive ◽  
Mri Thermometry ◽  
Magnetic Resonance Imaging Mri

We demonstrate the potential utility of spin crossover iron(ii) complexes as temperature-responsive paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in magnetic resonance imaging (MRI) thermometry.

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

scholarly journals Preparation and application of various nanoparticles in biology and medicine

2013 ◽  
Vol 3 (1) ◽  
pp. 2 ◽  
Author(s):  
Vardan Gasparyan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Optical Properties ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Gold And Silver Nanoparticles ◽  
Mri Contrast ◽  
Cellular Processes ◽  
Magnetic Resonance Imaging Mri

The present paper considers prospects for application of various nanoparticles in biology and medicine. Here are presented data on preparation of gold and silver nanoparticles, and effects of shape of these nanoparticles on their optical properties. Application of these nanoparticles in diagnostics, for drug delivery and therapy, and preparation of magnetic nanoparticles from iron and cobalt salts are also discussed. Application of these nanoparticles as magnetic resonance imaging (MRI) contrast agents and as vehicles for drug delivery, and preparation of quantum dots and their application as prospective nanoparticles for multiplex analysis and for visualization of cellular processes will be tackled. Finally, prospects for new types of nanocomposites (metallic nano-shells) will be not overlooked.

scholarly journals Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

Processes ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 462 ◽  
Author(s):  
Karina Nava Andrade ◽  
Gregorio Guadalupe Carbajal Arízaga ◽  
José Antonio Rivera Mayorga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Molar Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Double Hydroxide ◽  
Double Hydroxides

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.

Glymphatic System Visualized by Chemical-Exchange-Saturation-Transfer Magnetic Resonance Imaging

2020 ◽  
Vol 11 (13) ◽  
pp. 1978-1984 ◽  
Author(s):  
Yuanfeng Chen ◽  
Zhuozhi Dai ◽  
Ruhang Fan ◽  
David John Mikulis ◽  
Jinming Qiu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Glymphatic System
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