Enantioselective synthesis of 3-substituted tryptamines as core components of central nervous system drugs and indole natural products

2013 ◽  
Vol 91 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Stephen Hanessian ◽  
Elia J.L. Stoffman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Natural Products ◽  
Enantioselective Synthesis ◽  
Central Nervous System Drugs ◽  
Iminium Ion ◽  
Core Components ◽  
Cns Drugs

Application of the MacMillan iminium ion Michael and Friedel–Crafts type reactions to γ-amino α,β-unsaturated butanals led to the corresponding β-substituted butanals in good yields and high enantioselectivities. The products could be useful intermediates in the synthesis of indole-based central nervous system (CNS) drugs and natural products.

scholarly journals Prospects for repurposing CNS drugs for cancer treatment

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Mohamed Abdelaleem ◽  
Hossam Ezzat ◽  
Muhammed Osama ◽  
Adel Megahed ◽  
Waleed Alaa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Repurposing ◽  
New Approach ◽  
Central Nervous System Drugs ◽  
Anti Cancer ◽  
Cns Drugs ◽  
New Anticancer Drugs

Drug repurposing is the idea of using an already approved drug for another disease or disorder away from its initial use. This new approach ensures the reduction in high cost required for developing a new drug in addition to the time consumed, especially in the tumor disorders that show an unceasing rising rate with an unmet success rate of new anticancer drugs. In our review, we will review the anti-cancer effect of some CNS drugs, including both therapeutic and preventive, by searching the literature for preclinical or clinical evidence for anticancer potential of central nervous system drugs over the last 8 years period (2010-2018) and including only evidence from Q1 journals as indicated by Scimago website (www.scimagojr.com). We concluded that Some Central Nervous system drugs show a great potential as anti-cancer in vitro, in vivo and clinical trials through different mechanisms and pathways in different types of cancer that reveal a promising evidence for the repurposing of CNS drugs for new indications.

scholarly journals Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites

The Analyst ◽  
2020 ◽  
Vol 145 (17) ◽  
pp. 5744-5753 ◽  
Author(s):  
Michele Protti ◽  
Camilla Marasca ◽  
Marco Cirrincione ◽  
Andrea Cavalli ◽  
Roberto Mandrioli ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Analytical Method ◽  
Dried Blood Spots ◽  
Blood Spots ◽  
Central Nervous System Drugs ◽  
Cns Drugs ◽  
Drugs And Metabolites

Development of an advanced analytical method coupling capillary dried blood spots and LC-MS/MS for the TDM of patients undergoing treatment with CNS drugs.

Prodrug strategies in the CNS drugs: small modification makes big improvements

2021 ◽  
Vol 21 ◽  
Author(s):  
Ting Kang ◽  
Zhuang Miao ◽  
Siyu Liu ◽  
Bowen Ke
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Development ◽  
The Central Nervous System ◽  
Cns Drugs

: Prodrug design is an effective method proven to improve the drug-like properties of a molecule, and it has been widely used in the drug development of various diseases. Due to the complexity of the central nervous system (CNS), the development of CNS drugs has high requirements related to the pharmaceutical, pharmacokinetic, and pharmacodynamic properties of the molecules. Prodrug design has now been widely and successfully applied to improve these properties. We conducted a mini-review to promote the use of the prodrug strategies in CNS drug development. To facilitate the description, we chose drug indications as a clue, then presented and discussed some representative CNS prodrugs. Finally, a brief summary and outlook about this area were presented.

Central Nervous System Drugs

1987 ◽  
pp. 58-97
Author(s):  
J. M. Carney ◽  
H. D. Christensen ◽  
L. A. Reinke ◽  
L. E. Rikans
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Drugs
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