Effects of inflammatory bowel diseases on bone metabolism

IBMS BoneKEy ◽  
2009 ◽  
Vol 6 (11) ◽  
pp. 420-428
Author(s):  
Francisco A Sylvester
Keyword(s):  
Bone Metabolism ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases

2011 ◽  
Vol 300 (2) ◽  
pp. G191-G201 ◽  
Author(s):  
Fayez K. Ghishan ◽  
Pawel R. Kiela
Keyword(s):  
Vitamin D ◽  
Bone Metabolism ◽  
Inflammatory Mediators ◽  
Inflammatory Bowel Diseases ◽  
Experimental Models ◽  
Mineral Density ◽  
Anabolic Hormone ◽  
Increased Risk ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Chronic inflammatory disorders such as inflammatory bowel diseases (IBDs) affect bone metabolism and are frequently associated with the presence of osteopenia, osteoporosis, and increased risk of fractures. Although several mechanisms may contribute to skeletal abnormalities in IBD patients, inflammation and inflammatory mediators such as TNF, IL-1β, and IL-6 may be the most critical. It is not clear whether the changes in bone metabolism leading to decreased mineral density are the result of decreased bone formation, increased bone resorption, or both, with varying results reported in experimental models of IBD and in pediatric and adult IBD patients. New data, including our own, challenge the conventional views, and contributes to the unraveling of an increasingly complex network of interactions leading to the inflammation-associated bone loss. Since nutritional interventions (dietary calcium and vitamin D supplementation) are of limited efficacy in IBD patients, understanding the pathophysiology of osteopenia and osteoporosis in Crohn's disease and ulcerative colitis is critical for the correct choice of available treatments or the development of new targeted therapies. In this review, we discuss current concepts explaining the effects of inflammation, inflammatory mediators and their signaling effectors on calcium and phosphate homeostasis, osteoblast and osteoclast function, and the potential limitations of vitamin D used as an immunomodulator and anabolic hormone in IBD.

scholarly journals Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 216
Author(s):  
Alicja Ewa Ratajczak ◽  
Aleksandra Szymczak-Tomczak ◽  
Agnieszka Zawada ◽  
Anna Maria Rychter ◽  
Agnieszka Dobrowolska ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Inflammatory Bowel Diseases ◽  
Genetic Factors ◽  
Lower Bone Mineral Density ◽  
Mineral Density ◽  
Bowel Diseases ◽  
Other Substances ◽  
Inflammatory Bowel ◽  
Diet Level ◽  
Affect Bone Metabolism

Patients suffering from Crohn’s disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimulants. Coffee and tea contain numerous compounds affecting bone metabolism. Certain substances such as antioxidants may protect bones; other substances may increase bone resorption. Nevertheless, the influence of coffee and tea on the development and course of inflammatory bowel diseases is contradictory.

scholarly journals Bone Metabolism in Inflammatory Bowel Diseases 2

2020 ◽  
Vol 66 (7) ◽  
pp. 432-436
Author(s):  
Tomáš Kupka ◽  
Pavel Svoboda ◽  
Martina Bojková ◽  
Martin Blaho ◽  
Adam Vašura ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

P.14.1 EVALUATION OF BONE METABOLISM DURING ANTI-TNF THERAPY IN INFLAMMATORY BOWEL DISEASES

2016 ◽  
Vol 48 ◽  
pp. e194
Author(s):  
C. Petruzzellis ◽  
L. Sparano ◽  
P. Cesari ◽  
C. Boselli ◽  
F. Pagani
Keyword(s):  
Bone Metabolism ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Interleukin 6, osteoprotegerin, sRANKL and bone metabolism in inflammatory bowel diseases

2018 ◽  
Vol 27 (4) ◽  
pp. 449-453 ◽  
Author(s):  
Iwona Krela-Kaźmierczak ◽  
Aleksandra Szymczak-Tomczak ◽  
Liliana Łykowska-Szuber ◽  
Ewa Wysocka ◽  
Michał Michalak ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Inflammatory Bowel Diseases ◽  
Interleukin 6 ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Bone metabolism in inflammatory bowel diseases 1

2020 ◽  
Vol 66 (7) ◽  
pp. e3-e7
Author(s):  
Tomáš Kupka ◽  
Pavel Svoboda ◽  
Martina Bojková ◽  
Martin Blaho ◽  
Adam Vašura ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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