Modeling and Analysis of the Implementation of the Wolbachia Incompatible and Sterile Insect Technique for Mosquito Population Suppression

2021 ◽  
Vol 81 (2) ◽  
pp. 718-740
Author(s):  
Bo Zheng ◽  
Jianshe Yu ◽  
Jia Li
Keyword(s):  
Sterile Insect Technique ◽  
Mosquito Population ◽  
Modeling And Analysis ◽  
Population Suppression

A Framework for Modeling Genetically-Aware Mosquito Vectors for Sterile Insect Technique

2012 ◽  
pp. 256-274
Author(s):  
James E. Gentile ◽  
Samuel S. C. Rund
Keyword(s):  
Infectious Disease ◽  
Software Architecture ◽  
Sterile Insect Technique ◽  
Mosquito Population ◽  
Proof Of Concept ◽  
Targeted Intervention ◽  
Mosquito Vectors ◽  
Vector Borne Diseases ◽  
The World ◽  
Vector Borne

Vector-borne diseases account for 16% of the global infectious disease burden (WHO, 2004). Many of these debilitating and sometimes fatal diseases are transmitted between human hosts by mosquitoes. Mosquito-targeted intervention methods have controlled or eliminated mosquito-borne diseases from many regions of the world but regions of constant transmission (holoendemic areas) still exist (Molineaux et al., 1980). To eliminate these illnesses, researchers need to understand how interventions impact a mosquito population so as to identify potential avenues for new intervention techniques. This paper presents a software architecture that allows researchers to simulate transgenic interventions on a mosquito population. The authors present specifications for a model that captures these transgenic aspects and present a software architecture that meets those needs. The authors also provide a proof of concept and some observations about sterile insect technique strategies as simulated by this architecture.

scholarly journals THE USE OF TRANSGENIC MOSQUITOES FOR PREVENTION OF SPREADOF ARBOVIRAL DISEASES

2019 ◽  
Vol 64 (3) ◽  
pp. 101-104
Author(s):  
G. G. Onishchenko ◽  
T. E. Sizikova ◽  
V. N. Lebedev ◽  
S. V. Borisevich
Keyword(s):  
Genetic Control ◽  
Sterile Insect Technique ◽  
Field Trials ◽  
Control Methods ◽  
Aedes Mosquitoes ◽  
Genetic Systems ◽  
Arboviral Diseases ◽  
Transgenic Technologies ◽  
Population Suppression ◽  
Transgenic Mosquitoes

The mosquitoes of Aedes genus are the most important vector such arboviral diseases as dengue, yellow, Chikungunya, West Nile and Zika fevers. Work is currently in progress to control the transmission of agents of these diseases by forming of transgenic mosquitoes in order to altering the capacity of wild mosquitoes to support of virus replication. There are two main strategies of genetic control of mosquitoes population. Sterile Insect Technique (SIT), that mainly uses population suppression methods for making self-sustaining genetic systems and Release of insects carrying of a Dominant Lethal (RIDL) that uses mainly gene transfer methods for making of self-limiting genetic systems. The RIDL is more expensive, but it has some significant preferences, according compares with SIT. The field trials of genetic control methods are conducted in several countries from 2009 to present time. Genetic control, transgenic technologies to induce sterility, genetic elimination and stable transformation of Aedes mosquitoes are viewed in this review.

scholarly journals Transforming Insect Population Control with Precision Guided Sterile Males

2018 ◽  
Author(s):  
Nikolay P. Kandul ◽  
Junru Liu ◽  
Hector M. Sanchez C. ◽  
Sean L. Wu ◽  
John M. Marshall ◽  
...  
Keyword(s):  
Sterile Insect Technique ◽  
Population Control ◽  
Disease Vectors ◽  
Genetic Technology ◽  
Adult Males ◽  
Agricultural Pests ◽  
Wild Populations ◽  
Environmentally Safe ◽  
Population Suppression ◽  
Control Insect

AbstractThe sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed “precision guided SIT” (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. To demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to transform our ability to control insect agricultural pests and disease vectors.

scholarly journals Stability and periodicity in a mosquito population suppression model composed of two sub-models

2021 ◽  
Author(s):  
Zhongcai Zhu ◽  
Bo Zheng ◽  
Yantao Shi ◽  
Rong Yan ◽  
Jianshe Yu
Keyword(s):  
Periodic Solution ◽  
Stable Equilibrium ◽  
Mosquito Population ◽  
Sexually Active ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Numerical Examples ◽  
Suppression Process ◽  
Population Suppression ◽  
Theoretical Results

AbstractIn this paper, we propose a mosquito population suppression model which is composed of two sub-models switching each other. We assume that the releases of sterile mosquitoes are periodic and impulsive, only sexually active sterile mosquitoes play a role in the mosquito population suppression process, and the survival probability is density-dependent. For the release waiting period T and the release amount c, we find three thresholds denoted by $$T^*$$ T ∗ , $$g^*$$ g ∗ , and $$c^*$$ c ∗ with $$c^*>g^*$$ c ∗ > g ∗ . We show that the origin is a globally or locally asymptotically stable equilibrium when $$c\ge c^*$$ c ≥ c ∗ and $$T\le T^*$$ T ≤ T ∗ , or $$c\in (g^*, c^*)$$ c ∈ ( g ∗ , c ∗ ) and $$T<T^*$$ T < T ∗ . We prove that the model generates a unique globally asymptotically stable T-periodic solution when either $$c\in (g^*, c^*)$$ c ∈ ( g ∗ , c ∗ ) and $$T=T^*$$ T = T ∗ , or $$c>g^*$$ c > g ∗ and $$T>T^*$$ T > T ∗ . Two numerical examples are provided to illustrate our theoretical results.

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