Canine genetics project reaches its next milestone

2017 ◽  
Vol 180 (24) ◽  
pp. 587.1-587
Keyword(s):  
Canine Genetics

Canine genetics

2009 ◽  
Vol 4 (6) ◽  
pp. 257
Author(s):  
Catherine André
Keyword(s):  
Canine Genetics

scholarly journals Every dog has its day: a new journal for canine genetics and epidemiology

2014 ◽  
Vol 1 (1) ◽  
pp. 1 ◽  
Author(s):  
William ER Ollier ◽  
Lorna J Kennedy
Keyword(s):  
Canine Genetics

scholarly journals Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 847
Author(s):  
Vidhya Jagannathan ◽  
Christophe Hitte ◽  
Jeffrey M. Kidd ◽  
Patrick Masterson ◽  
Terence D. Murphy ◽  
...  
Keyword(s):  
Reference Genome ◽  
Gene Annotation ◽  
Domestic Dog ◽  
Genetic Studies ◽  
Protein Coding ◽  
Canine Genetics ◽  
Long Read ◽  
And Behavior ◽  
New Protein ◽  
Initial Assembly

The domestic dog has evolved to be an important biomedical model for studies regarding the genetic basis of disease, morphology and behavior. Genetic studies in the dog have relied on a draft reference genome of a purebred female boxer dog named “Tasha” initially published in 2005. Derived from a Sanger whole genome shotgun sequencing approach coupled with limited clone-based sequencing, the initial assembly and subsequent updates have served as the predominant resource for canine genetics for 15 years. While the initial assembly produced a good-quality draft, as with all assemblies produced at the time, it contained gaps, assembly errors and missing sequences, particularly in GC-rich regions, which are found at many promoters and in the first exons of protein-coding genes. Here, we present Dog10K_Boxer_Tasha_1.0, an improved chromosome-level highly contiguous genome assembly of Tasha created with long-read technologies that increases sequence contiguity >100-fold, closes >23,000 gaps of the CanFam3.1 reference assembly and improves gene annotation by identifying >1200 new protein-coding transcripts. The assembly and annotation are available at NCBI under the accession GCF_000002285.5.

scholarly journals Canine Genetics and Genomics

2021 ◽  
Author(s):  
Edo D’Agaro ◽  
Andrea Favaro ◽  
Davide Rosa
Keyword(s):  
Heart Disease ◽  
Next Generation Sequencing ◽  
Genomic Data ◽  
Behavioral Traits ◽  
Canine Genetics ◽  
Genome Wide ◽  
Tremendous Progress ◽  
Dog Breed ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

In the past fifteen years, tremendous progress has been made in dog genomics. Several genetic aspects of cancer, heart disease, hip dysplasia, vision and hearing problems in dogs have been investigated and studied in detail. Genome-wide associative studies have made it possible to identify several genes associated with diseases, morphological and behavioral traits. The dog genome contains an extraordinary amount of genetic variability that distinguishes the different dog breeds. As a consequence of the selective programs, applied using stringent breed standards, each dog breed represents, today, a population isolated from the others. The availability of modern next generation sequencing (NGS) techniques and the identification of millions of single functional mutations (SNPs) has enabled us to obtain new and unknown detailed genomic data of the different breeds.

Canine Genetics Facilitates Understanding of Human Biology

2008 ◽  
pp. 11-24
Author(s):  
Elaine A. Ostrander ◽  
Heidi G. Parker ◽  
Nathan B. Sutter
Keyword(s):  
Human Biology ◽  
Canine Genetics

Canine genetics comes of age

2000 ◽  
Vol 16 (3) ◽  
pp. 117-124 ◽  
Author(s):  
Elaine A Ostrander ◽  
Francis Galibert ◽  
Donald F Patterson
Keyword(s):  
Canine Genetics

Canine Genetics

2001 ◽  
pp. 264-270
Author(s):  
E.A. Ostrander ◽  
R.K. Wayne
Keyword(s):  
Canine Genetics
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