Pharmacokinetics of a single oral administration of cefalexin in mares and foals

2011 ◽  
Vol 168 (16) ◽  
pp. 431-431
Author(s):  
G. J. B. Ladaga ◽  
F. P. Lezica ◽  
A. M. Barboni ◽  
J. A. Picos ◽  
G. A. de Erausquin
Keyword(s):  
Oral Administration ◽  
Single Oral Administration

Josamycin concentrations in radicular cysts following a single oral administration

1993 ◽  
Vol 24 (1) ◽  
pp. 143-145 ◽  
Author(s):  
Yoshiaki Akimoto ◽  
Yoshiko Mochizuki ◽  
Akio Uda ◽  
Hiroaki Omata ◽  
Sumio Saito ◽  
...  
Keyword(s):  
Oral Administration ◽  
Single Oral Administration

Pharmacokinetics and tolerance of the hypolipidaemic RP 54275 following single oral administration to male volunteers

1990 ◽  
Vol 183 (5) ◽  
pp. 1846-1847
Author(s):  
C.D. Evans ◽  
G.D. Jones ◽  
V. Facchini ◽  
J. McEwen ◽  
Y. Yeang
Keyword(s):  
Oral Administration ◽  
Male Volunteers ◽  
Single Oral Administration

Bioequivalence of Two Tablet Formulations of Atenolol after Single Oral Administration in Healthy Volunteers

2011 ◽  
Vol 50 (03) ◽  
pp. 243-247
Author(s):  
Ioannis Niopas ◽  
Athanasios Daftsios ◽  
Ioannis Xanthakis ◽  
Nicolaos Nikolaidis ◽  
Samuel Njau
Keyword(s):  
Oral Administration ◽  
Healthy Volunteers ◽  
Single Oral Administration ◽  
Tablet Formulations

scholarly journals Plasma profile of cimicoxib in sheep after oral administration at two different rates

2017 ◽  
Vol 20 (3) ◽  
pp. 535-538
Author(s):  
A. Di Salvo ◽  
M. Giorgi ◽  
H.K. Lee ◽  
C. Vercelli ◽  
F. Rueca ◽  
...  
Keyword(s):  
Oral Administration ◽  
Oral Treatment ◽  
Plasma Concentrations ◽  
Individual Variability ◽  
Maximum Plasma ◽  
Dose Rates ◽  
Single Oral Administration ◽  
Concentration Peak ◽  
Value Range ◽  
Slow Absorption

Abstract Sheep are often subjected to painful procedures and thus they need to be treated with analgesics. Nevertheless, knowledges about pharmacokinetic features of these drugs in this species are poor. The aim of this study was to evaluate plasma behaviour of cimicoxib in sheep after a single oral administration at two different dose rates (4 and 6 mg/kg). Maximum plasma concentrations of cimicoxib were equal to 273.78 (median value; range 189.00-567.32) and 565.01 (range 308.27-822.59) ng/mL after treatment with 4 and 6 mg/kg, respectively. The time of maximum concentration (Tmax) was achieved between 4 and 10 hours following treatment at the lower dose, and between 6 and 10 hours after the administration of the higher dose, with one sheep achieving the concentration peak at 0.75 hours. The slow absorption and the great individual variability in plasma concentration, probably due to ruminal effects, suggest that cimicoxib is not suitable for oral treatment in sheep.

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