Serological study of an outbreak of paresis due to equid herpesvirus 1 (EHV-1)

1976 ◽  
Vol 99 (1) ◽  
pp. 10-12 ◽  
Author(s):  
Z. Dinter ◽  
B. Klingeborn
Keyword(s):  
Serological Study ◽  
Equid Herpesvirus ◽  
Herpesvirus 1

scholarly journals Effect of tunicamycin and monensin on fusion and hemadsorptive activities of equid herpesvirus 1.

1991 ◽  
Vol 53 (1) ◽  
pp. 133-135
Author(s):  
Nobuo KOIZUMI ◽  
Eiichi HONDA ◽  
Tetsuo KUMAGAI ◽  
Katsunori OKAZAKI
Keyword(s):  
Equid Herpesvirus ◽  
Herpesvirus 1

scholarly journals Equid Herpesvirus 1 Infection in Mice.

1993 ◽  
Vol 55 (1) ◽  
pp. 119-121 ◽  
Author(s):  
Mamiko INAZU ◽  
Osamu TSUHA ◽  
Rikio KIRISAWA ◽  
Yoshimi KAWAKAMI ◽  
Hiroshi IWAI
Keyword(s):  
Equid Herpesvirus ◽  
Herpesvirus 1

Replication of equid herpesvirus-1 (EHV-1) in the testes and epididymides of ponies and venereal shedding of infectious virus

1996 ◽  
Vol 115 (4) ◽  
pp. 385-397 ◽  
Author(s):  
J.P. Tearle ◽  
K.C. Smith ◽  
M.S. Boyle ◽  
M.M. Binns ◽  
G.J. Livesay ◽  
...  
Keyword(s):  
Infectious Virus ◽  
Equid Herpesvirus ◽  
Herpesvirus 1

Trials of an inactivated equid herpesvirus 1 vaccine: challenge with a subtype 1 virus

1984 ◽  
Vol 114 (15) ◽  
pp. 369-374 ◽  
Author(s):  
R. Burrows ◽  
D. Goodridge ◽  
M. Denyer
Keyword(s):  
Equid Herpesvirus ◽  
Herpesvirus 1

scholarly journals Equid Herpesvirus 1 Targets the Sensitization and Induction Steps To Inhibit the Type I Interferon Response in Equine Endothelial Cells

2019 ◽  
Vol 93 (23) ◽  
Author(s):  
Fatai S. Oladunni ◽  
Sanjay Sarkar ◽  
Stephanie Reedy ◽  
Udeni B. R. Balasuriya ◽  
David W. Horohov ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cellular Level ◽  
Immune Defense ◽  
Interferon Response ◽  
Type I ◽  
Type I Ifn ◽  
Viral Pathogen ◽  
Equid Herpesvirus ◽  
Herpesvirus 1

ABSTRACT Equid herpesvirus 1 (EHV-1) is a viral pathogen of horse populations worldwide spread by the respiratory route and is known for causing outbreaks of neurologic syndromes and abortion storms. Previously, we demonstrated that an EHV-1 strain of the neuropathogenic genotype, T953, downregulates the beta interferon (IFN-β) response in vitro in equine endothelial cells (EECs) at 12 h postinfection (hpi). In the present study, we explored the molecular correlates of this inhibition as clues toward an understanding of the mechanism. Data from our study revealed that EHV-1 infection of EECs significantly reduced both Toll-like receptor 3 (TLR3) and TLR4 mRNA expression at 6 hpi and 12 hpi. While EHV-1 was able to significantly reduce IRF9 mRNA at both 6 hpi and 12 hpi, the virus significantly reduced IFN regulatory factor 7 (IRF7) mRNA only at 12 hpi. EHV-1 did not alter the cellular level of Janus-activated kinase 1 (JAK1) at any time point. However, EHV-1 reduced the cellular level of expression of tyrosine kinase 2 (TYK2) at 12 hpi. Downstream of JAK1-TYK2 signaling, EHV-1 blocked the phosphorylation and activation of signal transducer and activator of transcription 2 (STAT2) when coincubated with exogenous IFN, at 12 hpi, although not at 3 or 6 hpi. Immunofluorescence staining revealed that the virus prevented the nuclear translocation of STAT2 molecules, confirming the virus-mediated inhibition of STAT2 activation. The pattern of suppression of phosphorylation of STAT2 by EHV-1 implicated viral late gene expression. These data help illuminate how EHV-1 strategically inhibits the host innate immune defense by limiting steps required for type I IFN sensitization and induction. IMPORTANCE To date, no commercial vaccine label has a claim to be fully protective against the diseases caused by equid herpesvirus 1 (EHV-1), especially the neurologic form. The interferon (IFN) system, of which type I IFN is of great importance, still remains a viable immunotherapeutic option against EHV-1 infection. The type I IFN system has been exploited successfully to treat other viral infections, such as chronic hepatitis B and C in humans. The current state of research on how EHV-1 interferes with the protective effect of type I IFN has indicated transient induction of type I IFN production followed by a rapid shutdown in vitro in equine endothelial cells (EECs). The significance of our study is the identification of certain steps in the type I IFN signaling pathway targeted for inhibition by EHV-1. Understanding this pathogen-host relationship is essential for the long-term goal of developing effective immunotherapy against EHV-1.

Seroprevalence of Bovine Herpes Virus 1 (BoHV-1) in breeding bulls in Northeastern Anatolian Region of Turkey

2017 ◽  
Author(s):  
Volkan Yilmaz ◽  
Nuvit Coskun ◽  
Ozgur Celebi ◽  
Fatih Buyuk
Keyword(s):  
Small Scale ◽  
Eastern Anatolia ◽  
Serological Study ◽  
Bovine Herpesvirus 1 ◽  
Scale Family ◽  
North Eastern ◽  
Antibody Titres ◽  
Herpesvirus 1 ◽  
Bovine Herpes Virus 1 ◽  
Sera Samples

Bovine herpesvirus-1 (BoHV-1) is well recognized as a pathogen that infects the respiratory and reproductive tracts. This study is a serological investigation of BoHV-1 in breeding bulls at 1–5 years of age from small scale family operations in three Northeastern Anatolian provinces (Kars, Ardahan and Igdir) in Turkey. For this purpose, blood was collected from 250 breeding bulls and was tested for antibodies against BoHV-1 using the virus neutralization technique. Out of 250 blood sera samples tested, 110 (44.00%) were detected as positive against to BoHV-1 and antibody titres were found to be varied between 1/2- 1/64. Among the controlled regions, the highest seroprevalance of BoHV-1 infection was found in Kars (64.81%) followed by Ardahan (30.00%) and Igdir (26.82%) provinces. The results suggested that the infection was spreading in breeding bulls in small scale family operations. This study is the first serological study to determine seroprevalence of BoHV-1 infection in breeding bulls in North-eastern Anatolia region.

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