Involvement of diet in fatty liver and kidney syndrome in broiler chickens

1973 ◽  
Vol 92 (5) ◽  
pp. 118-119 ◽  
Author(s):  
R. Blair ◽  
C. Whitehead ◽  
D. Bannister ◽  
A. Evans
Keyword(s):  
Fatty Liver ◽  
Broiler Chickens ◽  
Liver And Kidney

scholarly journals A biochemical explanation for the fatty liver and kidney syndrome of broilers: its alleviation by the short-term use of dietary fat

1977 ◽  
Vol 38 (3) ◽  
pp. 319-328 ◽  
Author(s):  
D. Balnave ◽  
R. B. Cumming ◽  
T. M. Sutherland
Keyword(s):  
Fatty Liver ◽  
Broiler Chickens ◽  
Specific Activity ◽  
Liver Lipid ◽  
Liver Weight ◽  
Atp Citrate Lyase ◽  
Commercial Diet ◽  
Meat Meal ◽  
Citrate Lyase ◽  
Liver And Kidney

1. Fatty liver and kidney syndrome (FLKS) was induced in young broiler chickens by giving them a diet composed principally of wheat and meat meal.2. FLKS resulted in reduced growth and increased liver weight; fasting for 18 h increased mortality, liver lipid and the specific activity of hepatic ATP-citrate lyase compared with birds fed on a commercial diet. The specific activities of hepatic fructose-l,6-diphosphate-l-phosphohydrolase and pyruvate carboxylase were reduced in birds suffering from FLKS and fasted for 18 h.3. Feeding of the FLKS-inducing diet supplemented with 150 g animal tallow/kg for 54 h considerably reduced mortality while restoring liver composition and enzyme activities towards those observed in birds fed a commercial diet. Investigations indicated that the glycerol component of the fat was not responsible for the observed responses.4. The present results suggest that in FLKS insufficiencies of biotin are induced in specific enzyme systems, but the syndrome may be alleviated without the use of supplementary biotin.5. The evidence indicates that, when stressed, birds affected by FLKS die from the hypoglycaemia occurring as a result of a reduced capacity for gluconeogenesis.

scholarly journals Interrelationships between biotin, choline and other B-vitamins and the occurrence of fatty liver and kidney syndrome and sudden death syndrome in broiler chickens

1982 ◽  
Vol 48 (1) ◽  
pp. 177-184 ◽  
Author(s):  
C. C. Whitehead ◽  
C. J. Randall
Keyword(s):  
Sudden Death ◽  
Fatty Liver ◽  
Broiler Chickens ◽  
Dietary Supplementation ◽  
B Vitamins ◽  
Sudden Death Syndrome ◽  
Post Mortem ◽  
Deficient Diet ◽  
Liver And Kidney ◽  
B Vitamin

1. Addition of supplemental choline to a biotin-deficient diet decreased the biotin status of chicks and increased mortality from fatty liver and kidney syndrome (FLKS).2. Mortality was also increased by dietary supplementation with a mixture of other B-vitamins, excluding biotin, and was highest when the choline and B-vitamin supplements were combined.3. The occurrence of sudden death syndrome (SDS) was unaffected by dietary biotin concentration.4. A previously unreported condition was observed in which birds died showing post-mortem signs characteristic of both FLKS and SDS and whose occurrence was related to the biotin status of the chicks.

scholarly journals N-Acetylcysteine Alleviated the Deltamethrin-Induced Oxidative Cascade and Apoptosis in Liver and Kidney Tissues

2022 ◽  
Vol 19 (2) ◽  
pp. 638
Author(s):  
Ali Allam ◽  
Ahmed Abdeen ◽  
Hari Prasad Devkota ◽  
Samar S. Ibrahim ◽  
Gehan Youssef ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Caspase 3 ◽  
Kidney Injury ◽  
Renal Tissue ◽  
Health Issues ◽  
Significant Protection ◽  
Gene Expressions ◽  
Molecular Alterations ◽  
Liver And Kidney ◽  
Antioxidant Markers

Deltamethrin (DLM) is a synthetic pyrethroid with anti-acaricide and insecticidal properties. It is commonly used in agriculture and veterinary medicine. Humans and animals are exposed to DLM through the ingestion of polluted food and water, resulting in severe health issues. N-acetylcysteine (NAC) is a prodrug of L-cysteine, the precursor to glutathione. It can restore the oxidant-antioxidant balance. Therefore, this research aimed to examine whether NAC may protect broiler chickens against oxidative stress, at the level of biochemical and molecular alterations caused by DLM intoxication. The indicators of liver and kidney injury in the serum of DLM-intoxicated and NAC-treated groups were examined. Furthermore, lipid peroxidation, antioxidant markers, superoxide dismutase activity, and apoptotic gene expressions (caspase-3 and Bcl-2) were investigated. All parameters were significantly altered in the DLM-intoxicated group, suggesting that DLM could induce oxidative damage and apoptosis in hepato-renal tissue. The majority of the changes in the studied parameters were reversed when NAC therapy was used. In conclusion, by virtue of its antioxidant and antiapoptotic properties, NAC enabled the provision of significant protection effects against DLM-induced hepato-renal injury.

scholarly journals Selective Hematological, Biochemical and Pathological Alterations of Newcastle Virus in Naturally Infected and Vaccinated Broilers in Damietta Governorate of Egypt

2017 ◽  
Vol 74 (2) ◽  
pp. 139
Author(s):  
Shefaa A. M. EL-MANDRAWY ◽  
Shimaa A. A. ISMAIL
Keyword(s):  
Newcastle Disease ◽  
Broiler Chickens ◽  
Histopathological Examination ◽  
Hypochromic Anemia ◽  
Nasal Discharge ◽  
Tissue Samples ◽  
Group Iii ◽  
Group I ◽  
Liver And Kidney ◽  
G Ratio

Newcastle disease (ND) remains one of the most harmful poultry diseases that threaten the poultry industry producers all over the world, thus the present work was planned to investigate the hematological, biochemical, and pathological changes in vaccinated and non-vaccinated broiler chickens naturally infected with ND. The study was conducted on 45 broiler chickens, 35-days-old, from a private farm in Damietta governorate and used in this work, 15 chickens were clinically healthy (Group I), 30 chickens with ND symptoms divided into 15 non-vaccinated (Group II) and the other 15 chickens (Group III) were vaccinated with La Sota strain of NDV with a titre of 106.5 EID50. The disease was diagnosed by hem agglutination test as ND. Blood and tissue samples were collected for clinical-pathological and histopathological examination. The infected broiler chickens showed cyanosis, nasal discharge, edema of eyelid and white pasty diarrhea with nervous manifestations. Furthermore, microcytic hypochromic anemia with leukocytosis was observed. Biochemical studies revealed a significant decrease in serum total proteins, albumin and A/G ratio, with significant increases in serum activities of aspartate aminotransferase, creatinine, and uric acid and glucose concentration in addition to several histological alterations were significantly seen in brain, intestine, liver and kidney of the infected birds. All these disturbances were less severe in the vaccinated group than the non-vaccinated one. In conclusion, La Sota vaccine can increase the bird resistant against Newcastle disease virus induced blood disorders and hepatic-renal insufficiency in broiler chickens.

Fatty Liver and Kidney Syndrome in Chicks. Effects on Liver and Kidney of Diets Causing the Syndrome

1974 ◽  
Vol 17 (2) ◽  
pp. 222-225 ◽  
Author(s):  
C.C. Whitehead ◽  
D.W. Bannister ◽  
R. Blair ◽  
A.J. Evans
Keyword(s):  
Fatty Liver ◽  
Liver And Kidney

scholarly journals LC-MS/MS analysis of doxycycline residues in chicken tissues after oral administration

2014 ◽  
Vol 58 (4) ◽  
pp. 573-579 ◽  
Author(s):  
Anna Gajda ◽  
Andrzej Posyniak ◽  
Grzegorz Tomczyk
Keyword(s):  
Oral Administration ◽  
Broiler Chickens ◽  
Thigh Muscle ◽  
Limit Of Quantification ◽  
Limit Values ◽  
Chicken Tissues ◽  
Short Period ◽  
Liquid Chromatography Tandem Mass ◽  
Liver And Kidney

Abstract For the purpose of quantitative determination of doxycycline (DC) residues in tissues, a sensitive liquid chromatography - tandem mass spectrometry (LC-MS/MS) method was developed. The method was used to determine DC residues in chicken tissues (breast and thigh muscle, liver and kidney) after oral administration with drinking water to five-weak-old broiler chickens. The DC was administered for five consecutive days at a therapeutic dose of 10 mg/kg b.w. once a day. The tissues were collected after 6 h, 24 h, 7 d, and 8 d. The method was validated and the decision limit was established for muscle - 109.2 μg/kg, for liver - 326.1 μg/kg, and for kidney - 634.0 μg/kg. The detection limit was 2 μg/kg and the limit of quantification was 5 μg/kg. In a short period after ceasing the treatment, the detected concentrations of DC were much higher than the established maximum residue limit values. The highest residue concentrations of DC were observed in the kidney, followed by the liver and muscle. The lowest concentration of DC was determined in tight muscle.

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