Recent advances in canine medicine, with particular regard to blindness, viral hepatitis and post-infective neurological disorders

1951 ◽  
Vol 63 (18) ◽  
pp. 323-326 ◽  
Author(s):  
H. PARRY
Keyword(s):  
Viral Hepatitis ◽  
Neurological Disorders ◽  
Recent Advances

Recent advances on the synthesis of the antidepressant Paroxetine

2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues
Keyword(s):  
Total Synthesis ◽  
Neurological Disorders ◽  
Serotonin Reuptake ◽  
Potent Inhibitor ◽  
Starting Material ◽  
Substitution Pattern ◽  
Biological Probes ◽  
Recent Advances ◽  
Treatment Of Depression ◽  
Made In

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.

scholarly journals Recent advances in viral hepatitis

2009 ◽  
Vol 9 (6) ◽  
pp. 613-616 ◽  
Author(s):  
Graham R Foster
Keyword(s):  
Viral Hepatitis ◽  
Recent Advances

The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions

2018 ◽  
Vol 18 (7) ◽  
pp. 611-624 ◽  
Author(s):  
Robert A. Hillman ◽  
Jonathan W. Nadraws ◽  
Michael A. Bertucci
Keyword(s):  
Protein Interactions ◽  
Neurological Disorders ◽  
Endocrine Disorders ◽  
Protein Protein Interactions ◽  
Peptide Therapeutics ◽  
Stapled Peptide ◽  
Disease States ◽  
Structural Rigidity ◽  
Recent Advances ◽  
Pharmacokinetic Properties

Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine disorders and cardiovascular disease. Stapled peptides are an emerging intervention for these PPIs due to their improved structural rigidity and pharmacokinetic properties relative to unstapled peptides. This review details the most recent advances in the field of stapled peptide therapeutics, including the increasing variety of PPIs being targeted and types of peptide staples being employed.

Recent Advances in Viral Hepatitis

1976 ◽  
Vol 69 (4) ◽  
pp. 468-475
Author(s):  
JOSEPH L. MELNICK ◽  
F. BLAINE HOLLINGER ◽  
GORDON R. DREESMAN
Keyword(s):  
Viral Hepatitis ◽  
Recent Advances

scholarly journals Recent advances in small molecular modulators targeting histone deacetylase 6

2020 ◽  
Vol 2 (4) ◽  
pp. FDD53
Author(s):  
Yufeng Xiao ◽  
Xuan Zhang
Keyword(s):  
Drug Design ◽  
Histone Deacetylase ◽  
Neurological Disorders ◽  
Therapeutic Strategy ◽  
Structural Features ◽  
Biological Functions ◽  
Histone Deacetylase 6 ◽  
Selective Inhibitors ◽  
Recent Advances

Histone deacetylase 6 (HDAC6) is a unique isozyme in the HDAC family with various distinguished characters. HDAC6 is predominantly localized in the cytoplasm and has several specific nonhistone substrates, such as α-tubulin, cortactin, Hsp90, tau and peroxiredoxins. Accumulating evidence reveals that targeting HDAC6 may serve as a promising therapeutic strategy for the treatment of cancers, neurological disorders and immune diseases, making the development of HDAC6 inhibitors particularly attractive. Recently, multitarget drug design and proteolysis targeting chimera technology have also been applied in the discovery of novel small molecular modulators targeting HDAC6. In this review, we briefly describe the structural features and biological functions of HDAC6 and discuss the recent advances in HDAC6 modulators, including selective inhibitors, chimeric inhibitors and proteolysis targeting chimeras for multiple therapeutic purposes.

scholarly journals A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Idriss Ali Abdoulaye ◽  
Yi Jing Guo
Keyword(s):  
Neurological Disorders ◽  
Basic Structure ◽  
Apium Graveolens ◽  
Clinical Implementation ◽  
Neuroprotective Effects ◽  
Beneficial Effects ◽  
Recent Advances ◽  
Neurological Conditions ◽  
Made In ◽  
Game Changer

The research of alternative treatment for ischemic stroke and degenerative diseases has always been a priority in neurology. 3-N-Butylphthalide (NBP), a family of compounds initially isolated from the seeds ofApium graveolensLinn., has shown significant neuroprotective effects. Previous extensive studies have demonstrated that NBP promotes a better poststroke outcome and exerts a multitargeted action on several mechanisms, from oxidative stress to mitochondrial dysfunction to apoptosis to inflammation. Additionally, recent findings on several neurological disorders have shown that NBP’s beneficial effects extend beyond the management of stroke. However, despite the increasing number of studies toward a better understanding and the rapid advances made in therapeutic options, to date, dl-3-N-butylphthalide, a synthetic variation of l-3-N-butylphthalide, remains the only clinically approved anti-ischemic agent in China, stressing the difficulties for a viable and effective transition from experimental to clinical practice. Events indicate that NBP, due to its multitargeted effect and the adaptability of its basic structure, can be an important game changer and a precursor to a whole new therapeutic approach to several neurological conditions. The present review discusses recent advances pertaining to the neuroprotective mechanisms of NBP-derived compounds and the possibility of their clinical implementation in the management of various neurological conditions.

scholarly journals Gene Therapy for Neurological Disorders-A Review

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 250-255
Author(s):  
Pravalika ◽  
Yuvaraj Babu K ◽  
Gifrina Jayaraj
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Gene Therapy ◽  
Mouse Models ◽  
Neurological Disorders ◽  
Motor System ◽  
Review Article ◽  
Recent Advances ◽  
The Future

This review article is based on improving knowledge on gene therapy which treats many neurological disorders. 150 articles were obtained, and 36 articles were filtered. Gene therapy is one of the most important treatments in the future as well as in the present. It has high chances of reducing many disorders . Many neurological disorders have been cured, but still many more researches are being done to express the potential of gene therapy to its maximum. Gene therapy improves the motor system in mouse models. Few neurological disorders that can be treated are Alzheimer's disease and Parkinson's disease. This review is an attempt to update recent advances in gene therapy.

Recent Advances in Duck Viral Hepatitis

1986 ◽  
pp. 213-222
Author(s):  
H. Farmer ◽  
W. S. K. Chalmers ◽  
P. R. Woolcock
Keyword(s):  
Viral Hepatitis ◽  
Recent Advances
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