Similarity of the lesion profile of BSE in Portuguese cattle to that described in British cattle

2000 ◽  
Vol 147 (17) ◽  
pp. 486-488 ◽  
Author(s):  
L. Orge ◽  
A. C. Fernandes ◽  
M. Ramos ◽  
A. Galo ◽  
J. P. Simas
Keyword(s):  
Lesion Profile

Lesion Profile in Raptors Monitored During the 2016–2017 H5N8 Outbreak in Northern Germany

2018 ◽  
Vol 158 ◽  
pp. 114
Author(s):  
R. Ulrich ◽  
J. Schinköthe ◽  
O. Krone ◽  
T. Harder
Keyword(s):  
Northern Germany ◽  
Lesion Profile

scholarly journals Medial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 413
Author(s):  
Alberto Rábano ◽  
Carmen Guerrero Márquez ◽  
Ramón A. Juste ◽  
María V. Geijo ◽  
Miguel Calero
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Prion Diseases ◽  
Current Evidence ◽  
Neuron Populations ◽  
Jakob Disease ◽  
Protein Isoform ◽  
Prnp Codon ◽  
Lesion Profile ◽  
Codon 129

Human prion and non-prion neurodegenerative diseases share pathogenic mechanisms and neuropathological features. The lesion profile of a particular entity results from specific involvement of vulnerable neuron populations and connectivity circuits by a pathogenic protein isoform with strain-like properties. The lesion profile of the medial temporal lobe (MTL) was studied in postmortem tissue of 143 patients with human prion disease (HPD) including sporadic, genetic, and acquired forms. Most cases (90%) were classified according to PrPres type and/or PRNP codon 129 status, in addition to a full neuropathological profile. Mixed histotypes represented 29.4% of total sporadic Creutzfeldt-Jakob disease (sCJD) cases. An intensity score of involvement including spongiosis and astrogliosis was determined for the amygdala, presubiculum, subiculum, entorhinal cortex, CA1 to CA4 sectors of the hippocampal cortex, and dentate gyrus. Connectivity hubs within the MTL presented the highest scores. Diverse lesion profiles were obtained for different types and subtypes of HPD. Impact of mixed PrPres types on the MTL lesion profile was higher for sCJDMV2K cases than in other histotypes. Differences between MTL profiles was globally consistent with current evidence on specific strains in HPD. These results may be relevant for the analysis of possible strain effects in focal non-prion neurodegenerative conditions limited to the MTL.

scholarly journals Neuropathology of Animal Prion Diseases

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 466
Author(s):  
Leonor Orge ◽  
Carla Lima ◽  
Carla Machado ◽  
Paula Tavares ◽  
Paula Mendonça ◽  
...  
Keyword(s):  
Prion Diseases ◽  
Clinical Signs ◽  
Small Ruminants ◽  
Neuronal Loss ◽  
Cellular Prion Protein ◽  
Brain Inflammation ◽  
Transmissible Spongiform Encephalopathies ◽  
Spongiform Encephalopathy ◽  
Spongiform Encephalopathies ◽  
Lesion Profile

Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals. They are caused by the conversion of cellular prion protein (PrPC) into a misfolded pathological isoform (PrPSc or prion- proteinaceous infectious particle) that self-propagates by conformational conversion of PrPC. Yet by an unknown mechanism, PrPC can fold into different PrPSc conformers that may result in different prion strains that display specific disease phenotype (incubation time, clinical signs and lesion profile). Although the pathways for neurodegeneration as well as the involvement of brain inflammation in these diseases are not well understood, the spongiform changes, neuronal loss, gliosis and accumulation of PrPSc are the characteristic neuropathological lesions. Scrapie affecting small ruminants was the first identified TSE and has been considered the archetype of prion diseases, though atypical and new animal prion diseases continue to emerge highlighting the importance to investigate the lesion profile in naturally affected animals. In this report, we review the neuropathology and the neuroinflammation of animal prion diseases in natural hosts from scrapie, going through the zoonotic bovine spongiform encephalopathy (BSE), the chronic wasting disease (CWD) to the newly identified camel prion disease (CPD).

Vacuolar Lesion Profile in Sheep Scrapie: Factors Influencing its Variation and Relationship to Disease-specific PrP Accumulation

2002 ◽  
Vol 127 (1) ◽  
pp. 59-68 ◽  
Author(s):  
I. Begara-McGorum ◽  
L. González ◽  
M. Simmons ◽  
N. Hunter ◽  
F. Houston ◽  
...  
Keyword(s):  
Factors Influencing ◽  
Lesion Profile ◽  
Sheep Scrapie ◽  
Disease Specific

Three-dimensional tracking of lesion profile during laser surgery based on shock wave detection

2014 ◽  
Author(s):  
Erwin Bay ◽  
Xosé Luis Dean Ben ◽  
Genny A. Pang ◽  
Alexandre Douplik ◽  
Daniel Razansky
Keyword(s):  
Shock Wave ◽  
Laser Surgery ◽  
Three Dimensional ◽  
Wave Detection ◽  
Lesion Profile

Bilateral temporal lobe pathology with sparing of medial temporal lobe structures: Lesion profile and pattern of memory disorder

1994 ◽  
Vol 32 (1) ◽  
pp. 23-38 ◽  
Author(s):  
Narinder Kapur ◽  
David Ellison ◽  
Alan J. Parkin ◽  
Nicola M. Hunkin ◽  
Edmund Burrows ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Disorder ◽  
Lesion Profile
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