Haematological profile in foals during the first year of life

2019 ◽  
Vol 184 (16) ◽  
pp. 503-503 ◽  
Author(s):  
Babak Faramarzi ◽  
Lon Rich
Keyword(s):  
Venous Blood ◽  
Reference Intervals ◽  
First Year ◽  
Cell Counts ◽  
Haematological Values ◽  
Haematological Profile ◽  
White Blood Cell Counts ◽  
First Year Of Life ◽  
Changes Over Time ◽  
Over Time

Foals’ haematological values change constantly during their first year of life. The use of updated age-based reference intervals (RIs) is imperative for providing accurate diagnosis and optimum care for sick foals. The authors' objective was to provide updated RIs for 13 haematological values in 2, 7, 14, 30, 90, 180 and 365-day-old foals and to investigate the changes over time in each measured value. Venous blood was collected at those ages from clinically healthy foals. Thirteen haematological values were analysed. The 95% RIs were reported using a bootstrapping method. Differences over time were examined using Friedman test. RIs for each of the measured values were calculated. Results showed noticeable trends in changes over time in several values. Nevertheless, white blood cell counts significantly increased between day 2 and day 90 (P=0.011) while lymphocyte counts increased from day 2 up to day 180 (P=0.033). The mean corpuscular haemoglobin and mean corpuscular volume (P=0.011) significantly decreased between day 2 and day 90. Normal haematological values in foals not only differ from those in adult horses but also change throughout the first year of life; thus, it is critical that clinicians use age-based RIs when treating sick foals.

scholarly journals Three Manual Noncommercial Methods to Prepare Equine Platelet-Rich Plasma

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1478
Author(s):  
Lorenzo G. T. M. Segabinazzi ◽  
Giorgia Podico ◽  
Michael F. Rosser ◽  
Som G. Nanjappa ◽  
Marco A. Alvarenga ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Platelet Rich Plasma ◽  
Upright Position ◽  
Platelet Counts ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Platelet Concentration ◽  
Manual Methods ◽  
White Blood Cell Counts ◽  
Over Time

In light of PRP’s increasing popularity in veterinary practice, this study aimed to compare three manual methods to prepare and cool equine PRP. The blood of 18 clinically healthy mares was collected via venipuncture in a blood transfusion bag (method 1), blood tubes (method 2), and a syringe (method 3). In method 1, samples were double centrifuged; method 2 involved one centrifugation, and in method 3 the syringe was kept in an upright position to sediment for 4 h. After processing with three methods, PRP and platelet-poor plasma (PPP) were extracted and assessed for red (RBC) and white blood cell counts (WBC), platelet counts, and viability. In a subset of mares (n = 6), samples were processed with the three methods, and PRP was evaluated at 6 and 24 h postcooling at 5 °C. Method 1 resulted in the highest and method 3 in the lowest platelet concentration (p < 0.05), and the latter also had greater contamination with WBC than the others (p < 0.001). Platelet viability was similar across treatments (p > 0.05). Cooling for 24 h did not affect platelet counts in all methods (p > 0.05); however, platelet viability was reduced after cooling PRP produced by method 3 (p = 0.04), and agglutination increased over time in all methods (p < 0.001). The three methods increased (1.8–5.6-fold) platelet concentration in PRP compared to whole blood without compromising platelet viability. In conclusion, all three methods concentrated platelets and while cooling affected their viability. It remains unknown whether the different methods and cooling would affect PRP’s clinical efficacy.

scholarly journals Effects of Vocal Training on Students’ Voices in a Professional Drama School

OTO Open ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. 2473974X1986638
Author(s):  
Jacob I. Tower ◽  
Lynn Acton ◽  
Jessica Wolf ◽  
Walton Wilson ◽  
Nwanmegha Young
Keyword(s):  
Fundamental Frequency ◽  
Aerodynamic Characteristics ◽  
Voice Handicap Index ◽  
First Year ◽  
Medical Facility ◽  
Acoustic Measures ◽  
Vocal Training ◽  
Before And After ◽  
Changes Over Time ◽  
Over Time

Objective The purpose of this study was to investigate the effect of vocal training on acoustic and aerodynamic characteristics of student actors’ voices. Study Design Prospective cohort study. Setting Tertiary medical facility speech and swallow center. Subjects and Methods Acoustic, aerodynamic, and Voice Handicap Index–10 measures were collected from 14 first-year graduate-level drama students before and after a standard vocal training program and analyzed for changes over time. Results Among the aerodynamic measures that were collected, mean expiratory airflow was significantly reduced after vocal training. Among the acoustic measures that were collected, mean fundamental frequency was significantly increased after vocal training. On average, Voice Handicap Index–10 scores were unchanged after vocal training. Conclusion The cohort of drama students undergoing vocal training demonstrated improvements in voice aerodynamics, which indicate enhanced glottal efficiency after training. The present study also found an increased average fundamental frequency among the actors during sustained voicing and no changes in jitter and shimmer despite frequent performance.

scholarly journals Hematological and immunological effects of gallium, indium, and arsenic in light emitting diodes manufacturing workers

2015 ◽  
Vol 3 (1) ◽  
pp. 41 ◽  
Author(s):  
Yen-Hsiung Liao
Keyword(s):  
Light Emitting Diodes ◽  
Venous Blood ◽  
Hemoglobin Concentration ◽  
Interferon Γ ◽  
Mean Corpuscular Hemoglobin ◽  
Light Emitting ◽  
Cell Counts ◽  
Exposed Workers ◽  
Ifn Γ ◽  
White Blood Cell Counts

<p><strong>Purpose:</strong> To determine whether hematological and immunological changes occur in manufacturing workers in association with gallium, indium, and arsenic biomarkers in light-emitting diodes.</p><p><strong>Methods:</strong> 91exposed light-emitting diodes, workers and 24 referents were monitored for whole blood and urine levels of gallium, indium, and arsenic. Venous blood was also collected for routine and immunological analyses.</p><p><strong>Results:</strong> The mean levels of blood in, urine Ga, urine as, and mean corpuscular hemoglobin concentration (MCHC) in the exposed workers were significantly than in referents. The values of mean corpuscular volume (MCV), white blood cell counts (WBCs), neutrophils, lymphocytes, interferon-γ (IFN-γ), and IgG in the exposed workers were lower than in referents. Combined exposure to Ga, In, and As showed a significant change in trends of decreased MCV, WBCs, neutrophils, lymphocytes, IFN,γ, and IgG value, after adjusting for appropriate confounders.</p><p><strong>Conclusion:</strong> These findings indicated that heavier exposed to Ga, In, and As may suppress hematological and immunological variables.</p>

scholarly journals Early Introduction of Sugar-Sweetened Beverages and Caries Trajectories from Age 12 to 48 Months

2020 ◽  
Vol 99 (8) ◽  
pp. 898-906 ◽  
Author(s):  
E. Bernabé ◽  
H. Ballantyne ◽  
C. Longbottom ◽  
N.B. Pitts
Keyword(s):  
Dental Caries ◽  
Young Children ◽  
Later Life ◽  
Rate Of Change ◽  
First Year ◽  
Sugar Sweetened Beverages ◽  
Sweetened Beverages ◽  
The Mean ◽  
First Year Of Life ◽  
Over Time

Early exposure to sweet tastes predicts similar food preferences and eating behavior in later life and is associated with childhood obesity. The aim of this study was to explore the associations of early (during the first year of life) and subsequent intake of sugar-sweetened beverages (SSBs) with 4-y caries trajectories among Scottish young children. We used data from 1,111 Scottish children who were followed annually from age 12 to 48 mo (4 sweeps in total). SSB intake was reported by parents in every sweep. SSB intake was broken down into 2 components, the initial SSB intake and the deviation over time from that initial value. Childhood dental caries was clinically determined (including noncavitated and cavitated lesions) every year. The association of SSB intake with baseline decayed, missing, and filled tooth surfaces (dmfs) (intercept) and rate of change in dmfs over time (slope) was examined in 2-level linear mixed-effects models, with repeated observations nested within children. Both the initial SSB intake and the deviation from the initial SSB intake were positively associated with steeper caries trajectories. By sweep 4, the predicted mean dmfs difference was 1.73 between children with low and high initial SSB intake (1 standard deviation below and above the mean) and 1.17 between children with low and high deviation from their initial SSB intake (1 SD below and above the mean). The findings of this prospective study among Scottish young children provide evidence that the introduction of SSBs during the first year of life can put children in a trajectory of high levels of dental caries. They support current recommendations to avoid sugars for very young children and interventions targeting early feeding practices for caries prevention.

scholarly journals The gut virome of healthy children during the first year of life is diverse and dynamic

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0240958
Author(s):  
Blanca Taboada ◽  
Patricia Morán ◽  
Angélica Serrano-Vázquez ◽  
Pavel Iša ◽  
Liliana Rojas-Velázquez ◽  
...  
Keyword(s):  
Gastrointestinal Symptoms ◽  
First Year ◽  
Healthy Children ◽  
Virus Species ◽  
Human Pathogens ◽  
Eukaryotic Virus ◽  
One Year ◽  
First Year Of Life ◽  
Changes Over Time ◽  
Composition Changes

In this work, we determined the diversity and dynamics of the gut virome of infants during the first year of life. Fecal samples were collected monthly, from birth to one year of age, from three healthy children living in a semi-rural village in Mexico. Most of the viral reads were classified into six families of bacteriophages including five dsDNA virus families of the order Caudovirales, with Siphoviridae and Podoviridae being the most abundant. Eukaryotic viruses were detected as early as two weeks after birth and remained present all along the first year of life. Thirty-four different eukaryotic virus families were found, where eight of these families accounted for 98% of all eukaryotic viral reads: Anelloviridae, Astroviridae, Caliciviridae, Genomoviridae, Parvoviridae, Picornaviridae, Reoviridae and the plant-infecting viruses of the Virgaviridae family. Some viruses in these families are known human pathogens, and it is surprising that they were found during the first year of life in infants without gastrointestinal symptoms. The eukaryotic virus species richness found in this work was higher than that observed in previous studies; on average between 7 and 24 virus species were identified per sample. The richness and abundance of the eukaryotic virome significantly increased during the second semester of life, probably because of an increased environmental exposure of infants with age. Our findings suggest an early and permanent contact of infants with a diverse array of bacteriophages and eukaryotic viruses, whose composition changes over time. The bacteriophages and eukaryotic viruses found in these children could represent a metastable virome, whose potential influence on the development of the infant’s immune system or on the health of the infants later in life, remains to be investigated.

Nonthyroidal Illness Syndrome in Ischaemic Stroke Patients is Associated with Increased Mortality

2019 ◽  
Vol 128 (12) ◽  
pp. 811-818 ◽  
Author(s):  
Saulius Taroza ◽  
Daiva Rastenytė ◽  
Aurelija Podlipskytė ◽  
Henrikas Kazlauskas ◽  
Narseta Mickuvienė
Keyword(s):  
Venous Blood ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
First Year ◽  
Free Triiodothyronine ◽  
Kaplan Meier ◽  
Index Stroke ◽  
Thyroid Axis ◽  
Changes Over Time ◽  
Overall Mortality

Abstract Background Results of studies on associations between triiodothyronine serum levels and mortality after acute ischemic stroke (AIS) are inconsistent. Therefore, the aim of this prospective study was to evaluate links between serum levels of thyroid axis associated hormones and all-cause mortality during 1 year after AIS. Methods and results This study involved 255 patients with AIS. Patients were divided into two groups: those who survived 1 year after their index stroke and those who not, and by quartiles of free triiodothyronine (FT3) and ΔFT3 (difference between basal FT3 and repeated FT3 on discharge) hormone serum concentrations. To assess serum levels of thyroid stimulating hormone (TSH), FT3 and free tetraiodothyronine (FT4), venous blood was taken from all included patients on admission to hospital. On discharge, blood tests were repeated for 178 (69.8%) patients. Study endpoints were overall mortality within 30, 90 and 365 days after AIS. Results Compared with the survivals, those who died had significantly lower mean FT3, FT3/FT4 ratio in all periods and lower median TSH within 30 days. Higher FT3 serum levels versus lower, even after adjustment for included important variables, remained significant for lower odds of death within 365 days after AIS (OR=0.57; 95% CI: 0.33–0.97, p=0.04), but added insignificant additional predictive value to the NIHSS score or age. Kaplan–Meier survival curves demonstrated that the first FT3 quartile was significantly associated with increased mortality compared with all other quartiles within 365 days after AIS. With ΔFT3 quartiles no such association was found. Conclusions. Higher FT3 levels on admission versus lower are significantly associated with lower mortality within 365 days after AIS. FT3 serum levels changes over time didn’t show any association with mortality within first year.

scholarly journals Plasmodium malaria and antimalarial antibodies in the first year of life

Parasitology ◽  
2016 ◽  
Vol 143 (2) ◽  
pp. 129-138 ◽  
Author(s):  
KATHERINE R. DOBBS ◽  
ARLENE E. DENT
Keyword(s):  
Severe Disease ◽  
Target Population ◽  
Antibody Responses ◽  
First Year ◽  
Malaria Vaccines ◽  
Prevailing Paradigm ◽  
Young Infants ◽  
Repeated Infections ◽  
First Year Of Life ◽  
Over Time

SUMMARYMalaria is one of the most serious infectious diseases with most of the severe disease caused byPlasmodium falciparum(Pf). Naturally acquired immunity develops over time after repeated infections and the development of antimalarial antibodies is thought to play a crucial role. Neonates and young infants are relatively protected from symptomatic malaria through mechanisms that are poorly understood. The prevailing paradigm is that maternal antimalarial antibodies transferred to the fetus in the last trimester of pregnancy protect the infant from early infections. These antimalarial antibodies wane by approximately 6 months of age leaving the infant vulnerable to malaria, however direct evidence supporting this epidemiologically based paradigm is lacking. As infants are the target population for future malaria vaccines, understanding how they begin to develop immunity to malaria and the gaps in their responses is key. This review summarizes the antimalarial antibody responses detected in infants and how they change over time. We focus primarily on Pf antibody responses and will briefly mentionPlasmodium vivaxresponses in infants.

Study of the relationship between overjet development and some skull bone measurements in Warmblood foals

2018 ◽  
Vol 183 (11) ◽  
pp. 353-353 ◽  
Author(s):  
Natalia Domanska-Kruppa ◽  
Monica Venner ◽  
Astrid Bienert-Zeit
Keyword(s):  
Measurement Technique ◽  
Horizontal Direction ◽  
First Year ◽  
Skull Bone ◽  
Dental Wear ◽  
Longitudinal Changes ◽  
First Year Of Life ◽  
The Relationship ◽  
Over Time ◽  
Skull Bones

Overjet is defined as the projection of the maxillary incisors labial to their antagonists in a horizontal direction. This malocclusion in horses can lead to incorrect dental wear and is aesthetically undesirable. Whether lengthening of the maxilla or shortening of the mandible causes the condition has not yet been determined. Therefore, a measurement technique was developed to investigate the correlations between skull bone measurements in overjet-affected individuals. The position of the incisors in 650 Warmblood foals born in a private German stud was examined at two weeks of age, revealing the prevalence of overjet to be 2 per cent. Five measurements were made on each foal’s head and comparisons with a second set of measurements that were made later in the foals first year showed a change in the presence or degree of overjet over time. Nine of 13 foals diagnosed with measurable overjet at the beginning of the study resolved spontaneously. Thirteen foals had no evidence of overjet at birth, of which four developed the condition during the first year of life. The methods used for measuring longitudinal changes in different skull bones and for the assessment of malocclusion in foals affected with overjet were considered effective.

Maternal parenting stress changes over the first year of life in infants with complex cardiac defects and in healthy infants

2021 ◽  
pp. 1-7
Author(s):  
Nadya Golfenshtein ◽  
Alexandra L Hanlon ◽  
Janet A Deatrick ◽  
Barbara Medoff-Cooper
Keyword(s):  
Parenting Stress ◽  
Parenting Practices ◽  
Stress Index ◽  
First Year ◽  
Cardiac Defects ◽  
Healthy Infants ◽  
Stress Changes ◽  
Parent Domain ◽  
Changes Over Time ◽  
Over Time

Abstract Objectives: Parents of infants with CHDs experience increased parenting stress compared to the general population, potentially interfering with parenting practices and bear adverse family outcomes. The changes in stress over the critical period of infancy have yet to be studied. The current study aimed to compare parenting stress changes over time between parents of infants with CHDs and parents of healthy infants during the first year of infants’ life. Methods: Data from a larger prospective cohort study were longitudinally analysed using mixed-effects multivariable regression modelling. Sample included mothers of 129 infants with complex cardiac defects and healthy infants, recruited from the cardiac ICU of a large cardiac centre and outpatient paediatric practices in Northeastern America. Outcome was measured over four visits via the Parenting Stress Index Long Form. Results: Stress in the cardiac group has significantly decreased over time on the Parent Domain (p = 0.025), and stress in the healthy group has significantly increased over time on the Child Domain (p = 0.033). Parenting stress trajectories demonstrated significant differences between groups on the Parent Domain (p = 0.026) and on the Total Stress (p = 0.039) subscales. Conclusions: Parenting stress in the paediatric cardiac population changes over time and differs from stress experienced by parents of healthy infants. Findings highlight stressful periods that may be potentially risky for parents of infants with CHDs and introduce additional illness-related and psychosocial/familial aspects to the parenting stress concept.

scholarly journals The Fetal Antibiotic EXposure (FAX) Study: Research on the Effect of in-utero antibiotic exposure on childhood outcomes (Preprint)

2018 ◽  
Author(s):  
Corinna Koebnick ◽  
Sara Y. Tartof ◽  
Margo A. Sidell ◽  
Emily Rozema ◽  
Joanie J Chung ◽  
...  
Keyword(s):  
In Utero ◽  
Autism Spectrum ◽  
Adverse Outcomes ◽  
First Year ◽  
In Utero Exposure ◽  
Study Cohort ◽  
Antibiotic Exposure ◽  
Real World Data ◽  
First Year Of Life ◽  
Over Time

BACKGROUND The widespread use of antepartum and intrapartum antibiotics has raised concerns about the possible disruption of the child's gut microbiota, and effects on the ‘maturation’ from the infant to the adult microbiome. The Fetal Antibiotic EXposure (FAX) Study provides a cohort to examine the association between in-utero exposure to antibiotics and adverse childhood outcomes including body weight, atopic diseases, and autism spectrum disorders and to investigate the role of other potential factors mitigating or moderating the risk for adverse outcomes. OBJECTIVE To describe the methods, cohort characteristics, and retention of infants included in the study cohort. METHODS For this retrospective cohort study, we included children born in KPSC hospitals between January 1, 2007 and December 31, 2015 within 22-44 weeks of gestation with KPSC insurance coverage during the first year of life. Follow-up data collection is through electronic medical record (EMR) data from Kaiser Permanente Southern California (KPSC). RESULTS The study cohort was comprised of 223,431 children of which 65.7% were exposed to antibiotics in-utero; 19.0% were exposed during the antepartum period, 30.0% during the intrapartum period, and 16.7% exposed during both the antepartum and intrapartum periods. During their first year of life, children had a median of 5 BMI measurements; the frequency of BMI measurements declined to a median of 3 in their second year of life and 2 for 3-5 years of age. The 5-year retention of children in the health plan was over 80% with the highest retention for Hispanic children. CONCLUSIONS This cohort of children will provide a unique opportunity to address key questions regarding the long-term sequelae of in-utero exposure to antibiotics using real-world data. The high retention and multiple medical visits over time allow us to model the trajectories of BMI over time.

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