Effects of long-term use of the preferential COX-2 inhibitor meloxicam on growing pigs

2017 ◽  
Vol 181 (21) ◽  
pp. 564-564 ◽  
Author(s):  
Ben M C Gorissen ◽  
Joost J Uilenreef ◽  
Wilhelmina Bergmann ◽  
Ellen Meijer ◽  
Bert van Rietbergen ◽  
...  
Keyword(s):  
Side Effects ◽  
Trabecular Bone ◽  
Growth Plate ◽  
Bone Microarchitecture ◽  
Growing Pigs ◽  
Pathological Examination ◽  
Trabecular Bone Microarchitecture ◽  
Cox 2 ◽  
Plate Morphology

Meloxicam, a preferential COX-2 inhibitor, is a commonly used NSAID in pigs. Besides having potential side effects on the gastrointestinal tract, this type of drug might potentially affect osteogenesis and chondrogenesis, processes relevant to growing pigs. Therefore, the effects of long-term meloxicam treatment on growing pigs were studied. Twelve piglets (n=6 receiving daily meloxicam 0.4 mg/kg orally from 48 until 110 days of age; n=6 receiving only applesauce (vehicle control)) were subjected to visual and objective gait analysis by pressure plate measurements at several time points. Following euthanasia a complete postmortem examination was performed and samples of the talus and distal tibia, including the distal physis, were collected. Trabecular bone microarchitecture was analysed by microCT scanning, bone stiffness by compression testing and growth plate morphology using light microscopy. Animals were not lame and gait patterns did not differ between the groups. Pathological examination revealed no lesions compatible with known side effects of NSAIDs. Trabecular bone microarchitecture and growth plate morphology did not differ between the two groups. The findings of this in vivo study reduce concerns regarding the long-term use of meloxicam in young, growing piglets.

Surface curvatures of trabecular bone microarchitecture

Bone ◽  
2002 ◽  
Vol 30 (1) ◽  
pp. 191-194 ◽  
Author(s):  
H Jinnai ◽  
H Watashiba ◽  
T Kajihara ◽  
Y Nishikawa ◽  
M Takahashi ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Microarchitecture ◽  
Trabecular Bone Microarchitecture

Dental Cone Beam Computed Tomography for Trabecular Bone Quality Analysis in Maxilla and Mandible

2021 ◽  
pp. 542-564
Author(s):  
T. Christy Bobby ◽  
Shwetha V. ◽  
Vijaya Madhavi
Keyword(s):  
Trabecular Bone ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Microarchitecture ◽  
Quality Analysis ◽  
Trabecular Bone Microarchitecture ◽  
The Stability ◽  
Maxilla And Mandible ◽  
Trabecular Bone Quality ◽  
Implant Treatment

The stability of a dental implant is one of the most important aspects that decide the success rate of implant treatment. The stability is considerably affected by the strength of trabecular bone present in maxilla and mandible. Thus, finding of trabecular bone strength is a key component for the success of dental implants. The trabecular bone strength is usually assessed by quantity of bone in terms of bone mineral density (BMD). Recently, it has been revealed that along with quantity of bone, strength of the bone also depends on quality features commonly referred as trabecular bone microarchitecture. Since the quality of the trabecular bone is varying across the maxilla and mandible, preoperative assessment of trabecular bone microarchitecture at sub-region of maxilla and mandible are essential for stable implant treatment. Thus, in this chapter, the authors inscribe the quantitative analysis of trabecular bone quality in maxilla and mandible using CBCT images by employing contourlet transform.

scholarly journals Bone Micro-CT Assessments in an Orchidectomised Rat Model Supplemented withEurycoma longifolia

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Rosmaliza Ramli ◽  
Mohd Fadhli Khamis ◽  
Ahmad Nazrun Shuid
Keyword(s):  
Trabecular Bone ◽  
Bone Microarchitecture ◽  
Bone Volume ◽  
High Dose ◽  
Micro Ct ◽  
Sprague Dawley ◽  
Elderly Male ◽  
Trabecular Bone Microarchitecture ◽  
Eurycoma Longifolia ◽  
Induced Changes

Recent studies suggested thatEurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects ofEurycoma longifoliasupplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10–12 months old)Sprague Dawleyrats were divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7 mg/rat testosterone enanthate (TEN) and orchidectomised +Eurycoma longifolia30 mg/kg (EL30), orchidectomised +Eurycoma longifolia60 mg/kg (EL60), orchidectomised +Eurycoma longifolia90 mg/kg (EL90). Rats were euthanized following six weeks of treatment. The left femora were used to measure the trabecular bone microarchitecture using micro-CT. Orchidectomy significantly decreased connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group. Testosterone replacement reversed all the orchidectomy-induced changes in the micro-CT parameters. EL at 30 and 60 mg/kg rat worsened the trabecular bone connectivity density and trabecular separation parameters of orchidectomised rats. EL at 90 mg/kg rat preserved the bone volume. High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but lower doses may further worsen the osteoporotic changes.

Sign in / Sign up

Export Citation Format

Share Document