Role of the gastrointestinal microbiota in small animal health and disease

2017 ◽  
Vol 181 (14) ◽  
pp. 370-370 ◽  
Author(s):  
Alana Redfern ◽  
Jan Suchodolski ◽  
Albert Jergens
Keyword(s):  
Veterinary Medicine ◽  
Current Literature ◽  
Current Knowledge ◽  
Gastrointestinal Disease ◽  
Animal Health ◽  
Small Animal ◽  
Gastrointestinal Microbiota ◽  
Novel Therapy ◽  
Health And Disease

There is a large and emerging interest in the role of the gastrointestinal microbiota in health and disease. This paper serves to review the current knowledge and recommendations of the gastrointestinal microbiota in health and gastrointestinal disease. Further, this review evaluates the current literature and suggests guidelines for faecal microbial transplantation, a novel therapy for dysbiosis in veterinary medicine.

scholarly journals Peran dan Strategi Pengembangan Subsektor Peternakan dalam Pembangunan Kabupaten Agam Sumatera Barat

2017 ◽  
Vol 3 (2) ◽  
pp. 159
Author(s):  
Yulia Yulia ◽  
Lukman Mohammad Baga ◽  
Netti Tinaprilla
Keyword(s):  
Growth Rate ◽  
Development Strategy ◽  
Animal Health ◽  
Animal Husbandry ◽  
Appropriate Technology ◽  
Local Resources ◽  
Swot Matrix ◽  
Health And Disease ◽  
The Government

Agam District Government has the goal of improving economic growth rate of 5.94 percent in 2011 to 7.98 percent in 2017. However, the constraints experienced by the development of the animal husbandry sector is a decrease in the growth rate of the animal husbandry sector and the contribution to the GDP, it is necessary for the development of the animal husbandry subsector in Agam by taking into account various aspects. This study aims to analyze the potential and role of formulating priority strategies of alternative development strategy animal husbandry subsector. Results of the analysis of the animal husbandry subsector LQ is a commodity basis. The shift results proportional growth 10.72 percent negative growth. Region share growth of 2.33 percent. The results obtained from the alternative strategies SWOT matrix were analyzed using QSPM. development and coaching each region based on the existing potential (6.278), increasing the promotion and development of human resources breeder (5.773), to build and develop patterns of cooperation and mutual benefit (5.618), examination of animal health and disease prevention (5.406), implementation and development appropriate technology (5.330) and optimization in securing local resources (4.982). Selected strategic alternatives of highest appeal total development strategy as well as coaching is done each region based on the existing potential (6.278), then the suggestions can be made to the Government Agam namely increasing the number of livestock extension workers and attract investors to develop the livestock subsector in Agam District.

The human cortical autonomic network and volitional exercise in health and disease

2018 ◽  
Vol 43 (11) ◽  
pp. 1122-1130 ◽  
Author(s):  
Baraa K. Al-Khazraji ◽  
J. Kevin Shoemaker
Keyword(s):  
Current Knowledge ◽  
Insular Cortex ◽  
Cardiovascular Control ◽  
Anterior Cingulate ◽  
Disease States ◽  
Autonomic Activation ◽  
Imaging Research ◽  
Health And Disease ◽  
Cortical Regions

The autonomic nervous system elicits continuous beat-by-beat homeostatic adjustments to cardiovascular control. These modifications are mediated by sensory inputs (e.g., baroreceptors, metaboreceptors, pulmonary, thermoreceptors, and chemoreceptors afferents), integration at the brainstem control centres (i.e., medulla), and efferent autonomic neural outputs (e.g., spinal, preganglionic, and postganglionic pathways). However, extensive electrical stimulation and functional imaging research show that the brain’s higher cortical regions (e.g., insular cortex, medial prefrontal cortex, anterior cingulate cortex) partake in homeostatic regulation of the cardiovascular system at rest and during exercise. We now appreciate that these cortical areas form a network, namely the “cortical autonomic network” (CAN), which operate as part of a larger central autonomic network comprising 2-way communication of cortical and subcortical areas to exert autonomic influence. Interestingly, differential patterns of CAN activity and ensuing cardiovascular control are present in disease states, thereby highlighting the importance of considering the role of CAN as an integral aspect of cardiovascular regulation in health and disease. This review discusses current knowledge on human cortical autonomic activation during volitional exercise, and the role of exercise training on this activation in both health and disease.

The Salivary miRNome: A Promising Biomarker of Disease

MicroRNA ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Sara Tomei ◽  
Harshitha Shobha Manjunath ◽  
Selvasankar Murugesan ◽  
Souhaila Al Khodor
Keyword(s):  
Current Knowledge ◽  
Transcriptional Level ◽  
Biological Processes ◽  
Circulating Mirnas ◽  
Disease Pathogenesis ◽  
Technical Aspects ◽  
Recent Developments ◽  
Health And Disease ◽  
Non Coding Rnas

: MicroRNAs (miRNAs) are non-coding RNAs ranging from 18-24 nucleotides also known to regulate the human genome mainly at the post-transcriptional level. MiRNAs were shown to play an important role in most biological processes such as apoptosis and in the pathogenesis of many diseases such as cardiovascular diseases and cancer. Recent developments of advanced molecular high-throughput technologies have enhanced our knowledge of miRNAs. MiRNAs can now be discovered, interrogated, and quantified in various body fluids, and hence can serve as diagnostic and therapeutic markers for many diseases. While most studies use blood as a sample source to measure circulating miRNAs as possible biomarkers for disease pathogenesis, fewer studies have assessed the role of salivary miRNAs in health and disease. This review aims at providing an overview of the current knowledge of the salivary miRNome, addressing the technical aspects of saliva sampling and highlighting the applicability of miRNA screening to clinical practice.

scholarly journals The Gut Ecosystem: A Critical Player in Stroke

2020 ◽  
Author(s):  
Rosa Delgado Jiménez ◽  
Corinne Benakis
Keyword(s):  
Current Knowledge ◽  
Critical Factor ◽  
Intestinal Microbiome ◽  
Brain Disorders ◽  
Therapeutic Approaches ◽  
Health And Disease ◽  
Brain Stroke ◽  
The Brain ◽  
Improve Patient

AbstractThe intestinal microbiome is emerging as a critical factor in health and disease. The microbes, although spatially restricted to the gut, are communicating and modulating the function of distant organs such as the brain. Stroke and other neurological disorders are associated with a disrupted microbiota. In turn, stroke-induced dysbiosis has a major impact on the disease outcome by modulating the immune response. In this review, we present current knowledge on the role of the gut microbiome in stroke, one of the most devastating brain disorders worldwide with very limited therapeutic options, and we discuss novel insights into the gut-immune-brain axis after an ischemic insult. Understanding the nature of the gut bacteria-brain crosstalk may lead to microbiome-based therapeutic approaches that can improve patient recovery.

Autophagy in health and disease: focus on the cardiovascular system

2017 ◽  
Vol 61 (6) ◽  
pp. 721-732 ◽  
Author(s):  
Jeanne Mialet-Perez ◽  
Cécile Vindis
Keyword(s):  
Heart Failure ◽  
Cardiovascular System ◽  
Crucial Role ◽  
Current Knowledge ◽  
Cardiovascular Disorders ◽  
Health And Disease ◽  
And Function ◽  
Autophagy Activity ◽  
Disease Focus

Autophagy is a highly conserved mechanism of lysosome-mediated protein and organelle degradation that plays a crucial role in maintaining cellular homeostasis. In the last few years, specific functions for autophagy have been identified in many tissues and organs. In the cardiovascular system, autophagy appears to be essential to heart and vessel homeostasis and function; however defective or excessive autophagy activity seems to contribute to major cardiovascular disorders including heart failure (HF) or atherosclerosis. Here, we review the current knowledge on the role of cardiovascular autophagy in physiological and pathophysiological conditions.

scholarly journals Untangling the Cooperative Role of Nuclear Receptors in Cardiovascular Physiology and Disease

2021 ◽  
Vol 22 (15) ◽  
pp. 7775
Author(s):  
Ana Paredes ◽  
Rocio Santos-Clemente ◽  
Mercedes Ricote
Keyword(s):  
Molecular Mechanisms ◽  
Contractile Function ◽  
Current Knowledge ◽  
Treatment And Prevention ◽  
Glucose And Lipid Metabolism ◽  
Transcriptional Alterations ◽  
Health And Disease ◽  
Cellular Pathways ◽  
X Receptors

The heart is the first organ to acquire its physiological function during development, enabling it to supply the organism with oxygen and nutrients. Given this early commitment, cardiomyocytes were traditionally considered transcriptionally stable cells fully committed to contractile function. However, growing evidence suggests that the maintenance of cardiac function in health and disease depends on transcriptional and epigenetic regulation. Several studies have revealed that the complex transcriptional alterations underlying cardiovascular disease (CVD) manifestations such as myocardial infarction and hypertrophy is mediated by cardiac retinoid X receptors (RXR) and their partners. RXRs are members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors and drive essential biological processes such as ion handling, mitochondrial biogenesis, and glucose and lipid metabolism. RXRs are thus attractive molecular targets for the development of effective pharmacological strategies for CVD treatment and prevention. In this review, we summarize current knowledge of RXR partnership biology in cardiac homeostasis and disease, providing an up-to-date view of the molecular mechanisms and cellular pathways that sustain cardiomyocyte physiology.

Tending Animals in the Global VillageA Guide to International Veterinary Medicine . . . . Import Risk Analysis: Animals and Animal Products . . . . Exotic Pests & Disease: Biology and Economics for Biosecurity . . . . Borna Disease Virus and Its Role in Neurobehavioral Disease . . . . Foot and Mouth Disease: Facing the New Dilemmas . . . . Trends in Emerging Viral Infections of Swine . . . . Clinical Examination of Farm Animals . . . . Manual of Sheep Diseases (2nd edition) . . . . Mycotoxins: Risks in Plant, Animal, and Human Systems . . . . A Guide to Plant Poisoning of Animals in North America . . . . Diseases of Poultry (11th edition) . . . . Modern Concepts of Immunology in Veterinary MedicinePoultry Immunology (Advances in Medical and Veterinary Immunology) . . . . Pathology of Pet and Aviary Birds . . . . Birds of Prey: Health and Disease (3rd edition) . . . . Hand-Rearing Wild and Domestic Mammals . . . . Handbook of Wildlife Chemical Immobilization (International Edition) . . . . Veterinary Anesthesia and Pain Management Secrets . . . . The Veterinary ICU Book . . . . Anatomy of the Dog: An Illustrated Text (4th Edition) . . . . The 5-Minute Veterinary Consult Clinical Companion: Small Animal Dermatology . . . . Abdominal Radiology for the Small Animal Practitioner (Made Easy Series) . . . . Two Dimensional and M-Mode Echocardiography for the Small Animal Practitioner (Made Easy Series) . . . . Small Animal Ophthalmology Secrets . . . . Ocular Tumors in Animals and Humans . . . . Feline Oncology: A Comprehensive Guide to Compassionate Care . . . . Veterinary Medicine and Practice 25 Years in the Future and the Economic Steps to Get There

2003 ◽  
Vol 223 (6) ◽  
pp. 796-806
Author(s):  
Mustaq A. Memon ◽  
Wendy Fineblum Hall ◽  
James C. Wright ◽  
Massimo Palmarini ◽  
Martin E. Hugh-Jones ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Viral Infections ◽  
Small Animal ◽  
Foot And Mouth Disease ◽  
Farm Animals ◽  
Animal Products ◽  
Abdominal Radiology ◽  
Disease Biology ◽  
Exotic Pests ◽  
Health And Disease

The role of SLAM family receptors in immune cell signalingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.

2006 ◽  
Vol 84 (6) ◽  
pp. 832-843 ◽  
Author(s):  
Elena A. Ostrakhovitch ◽  
Shawn S.-C. Li
Keyword(s):  
Immune Cells ◽  
Immune Cell ◽  
Current Knowledge ◽  
Critical Role ◽  
Cell Types ◽  
Health And Disease ◽  
Slam Family ◽  
Different Cell Types ◽  
Selection Of

The signaling lymphocyte-activating molecule (SLAM) family immunoreceptors are expressed in a wide array of immune cells, including both T and B lymphocytes. By virtue of their ability to transduce tyrosine phosphorylation signals through the so-called ITSM (immunoreceptor tyrosine-based switch motif) sequences, they play an important part in regulating both innate and adaptive immune responses. The critical role of the SLAM immunoreceptors in mediating normal immune reactions was highlighted in recent findings that SAP, a SLAM-associated protein, modulates the activities of various immune cells through interactions with different members of the SLAM family expressed in these cells. Importantly, mutations or deletions of the sap gene in humans result in the X-linked lymphoproliferative syndrome. In this review, we summarize current knowledge and survey the latest developments in signal transduction events triggered by the activation of SLAM family receptors in different cell types.

scholarly journals Lysosome function in glomerular health and disease

2021 ◽  
Author(s):  
Catherine Meyer-Schwesinger
Keyword(s):  
Current Knowledge ◽  
Lysosomal Storage Diseases ◽  
Cell Types ◽  
Lysosomal Storage ◽  
Membrane Repair ◽  
Glomerular Cell ◽  
Wide Range ◽  
Center Position ◽  
Health And Disease

AbstractThe lysosome represents an important regulatory platform within numerous vesicle trafficking pathways including the endocytic, phagocytic, and autophagic pathways. Its ability to fuse with endosomes, phagosomes, and autophagosomes enables the lysosome to break down a wide range of both endogenous and exogenous cargo, including macromolecules, certain pathogens, and old or damaged organelles. Due to its center position in an intricate network of trafficking events, the lysosome has emerged as a central signaling node for sensing and orchestrating the cells metabolism and immune response, for inter-organelle and inter-cellular signaling and in membrane repair. This review highlights the current knowledge of general lysosome function and discusses these findings in their implication for renal glomerular cell types in health and disease including the involvement of glomerular cells in lysosomal storage diseases and the role of lysosomes in nongenetic glomerular injuries.

scholarly journals Antimicrobial use in food-producing animals: a rapid evidence assessment of stakeholder practices and beliefs

2017 ◽  
Vol 181 (19) ◽  
pp. 510-510 ◽  
Author(s):  
Jo Hockenhull ◽  
Andrea E Turner ◽  
Kristen K Reyher ◽  
David C Barrett ◽  
Laura Jones ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Antimicrobial Resistance ◽  
Potential Role ◽  
Current Knowledge ◽  
Antimicrobial Use ◽  
Livestock Industry ◽  
Animal Agriculture ◽  
The World ◽  
Public Pressure

Food-producing animals throughout the world are likely to be exposed to antimicrobial (AM) treatment. The crossover in AM use between human and veterinary medicine raises concerns that antimicrobial resistance (AMR) may spread from food-producing animals to humans, driving the need for further understanding of how AMs are used in livestock practice as well as stakeholder beliefs relating to their use. A rapid evidence assessment (REA) was used to collate research on AM use published in peer-reviewed journals between 2000 and 2016. Forty-eight papers were identified and reviewed. The summary of findings highlights a number of issues regarding current knowledge of the use of AMs in food-producing animals and explores the attitudes of interested parties regarding the reduction of AM use in livestock. Variation between and within countries, production types and individual farms demonstrates the complexity of the challenge involved in monitoring and regulating AM use in animal agriculture. Many factors that could influence the prevalence of AMR in livestock are of concern across all sections of the livestock industry. This REA highlights the potential role of farmers and veterinarians and of other advisors, public pressure and legislation to influence change in the use of AMs in livestock.

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