Prevalence factors associated with equine herpesvirus type 1 infection in equids with upper respiratory tract infection and/or acute onset of neurological signs from 2008 to 2014

2015 ◽  
pp. vetrec-2015-103424 ◽  
Author(s):  
N. Pusterla ◽  
S. Mapes ◽  
N. Akana ◽  
C. Barnett ◽  
C. MacKenzie ◽  
...  
Keyword(s):  
Tract Infection ◽  
Acute Onset ◽  
Equine Herpesvirus ◽  
Upper Respiratory Tract ◽  
Herpesvirus Type ◽  
Factors Associated ◽  
Neurological Signs ◽  
Equine Herpesvirus Type 1 ◽  
Upper Respiratory

scholarly journals Genome‐wide association study for host genetic factors associated with equine herpesvirus type‐1 induced myeloencephalopathy

2020 ◽  
Vol 52 (6) ◽  
pp. 794-798
Author(s):  
Wangisa M. B. Dunuwille ◽  
Navid YousefiMashouf ◽  
Udeni B. R. Balasuriya ◽  
Nicola Pusterla ◽  
Ernest Bailey
Keyword(s):  
Genetic Factors ◽  
Genome Wide Association Study ◽  
Equine Herpesvirus ◽  
Herpesvirus Type ◽  
Factors Associated ◽  
Genome Wide ◽  
Equine Herpesvirus Type 1 ◽  
Host Genetic ◽  
Host Genetic Factors

scholarly journals The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1

2021 ◽  
Vol 12 ◽  
Author(s):  
Kathlyn Laval ◽  
Katrien C. K. Poelaert ◽  
Jolien Van Cleemput ◽  
Jing Zhao ◽  
Annelies P. Vandekerckhove ◽  
...  
Keyword(s):  
Pseudorabies Virus ◽  
Current Knowledge ◽  
Equine Herpesvirus ◽  
Upper Respiratory Tract ◽  
Herpesvirus Type ◽  
Varicella Zoster ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1 ◽  
Horse Industry

Equine herpesvirus type 1 (EHV-1) is an alphaherpesvirus related to pseudorabies virus (PRV) and varicella-zoster virus (VZV). This virus is one of the major pathogens affecting horses worldwide. EHV-1 is responsible for respiratory disorders, abortion, neonatal foal death and equine herpes myeloencephalopathy (EHM). Over the last decade, EHV-1 has received growing attention due to the frequent outbreaks of abortions and/or EHM causing serious economical losses to the horse industry worldwide. To date, there are no effective antiviral drugs and current vaccines do not provide full protection against EHV-1-associated diseases. Therefore, there is an urgent need to gain a better understanding of the pathogenesis of EHV-1 in order to develop effective therapies. The main objective of this review is to provide state-of-the-art information on the pathogenesis of EHV-1. We also highlight recent findings on EHV-1 immune evasive strategies at the level of the upper respiratory tract, blood circulation and endothelium of target organs allowing the virus to disseminate undetected in the host. Finally, we discuss novel approaches for drug development based on our current knowledge of the pathogenesis of EHV-1.

scholarly journals Replication kinetics of neurovirulent versus non-neurovirulent equine herpesvirus type 1 strains in equine nasal mucosal explants

2010 ◽  
Vol 91 (8) ◽  
pp. 2019-2028 ◽  
Author(s):  
Annelies P. Vandekerckhove ◽  
S. Glorieux ◽  
A. C. Gryspeerdt ◽  
L. Steukers ◽  
L. Duchateau ◽  
...  
Keyword(s):  
Post Inoculation ◽  
Equine Herpesvirus ◽  
Upper Respiratory Tract ◽  
Herpesvirus Type ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1 ◽  
Infected Cells ◽  
Mucosal Explants

Equine herpesvirus type 1 (EHV-1) is the causative agent of equine herpes myeloencephalopathy, of which outbreaks are reported with increasing frequency throughout North America and Europe. This has resulted in its classification as a potentially emerging disease by the US Department of Agriculture. Recently, it was found that a single nucleotide polymorphism (SNP) in the viral DNA polymerase gene (ORF30) at aa 752 (N→D) is associated with the neurovirulent potential of EHV-1. In the present study, equine respiratory mucosal explants were inoculated with several Belgian isolates typed in their ORF30 as D752 or N752, to evaluate a possible difference in replication in the upper respiratory tract. In addition, to evaluate whether any observed differences could be attributed to the SNP associated with neurovirulence, the experiments were repeated with parental Ab4 (reference neurovirulent strain), parental NY03 (reference non-neurovirulent strain) and their N/D revertant recombinant viruses. The salient findings were that EHV-1 spreads plaquewise in the epithelium, but plaques never cross the basement membrane (BM). However, single EHV-1-infected cells could be observed below the BM at 36 h post-inoculation (p.i.) for all N752 isolates and at 24 h p.i. for all D752 isolates, and were identified as monocytic cells and T lymphocytes. Interestingly, the number of infected cells was two to five times higher for D752 isolates compared with N752 isolates at every time point analysed. Finally, this study showed that equine respiratory explants are a valuable and reproducible model to study EHV-1 neurovirulence in vitro, thereby reducing the need for horses as experimental animals.

Seroprevalence and factors associated with equine herpesvirus type 1 and 4 in Spanish Purebred horses in Spain

2016 ◽  
Vol 178 (16) ◽  
pp. 398-398 ◽  
Author(s):  
F. Cruz ◽  
P. Fores ◽  
L. Mughini-Gras ◽  
J. Ireland ◽  
M. A. Moreno ◽  
...  
Keyword(s):  
Equine Herpesvirus ◽  
Herpesvirus Type ◽  
Factors Associated ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1

scholarly journals Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenza

Vaccine ◽  
2008 ◽  
Vol 26 (19) ◽  
pp. 2335-2343 ◽  
Author(s):  
Cristina Rosas ◽  
Gerlinde R. Van de Walle ◽  
Stephan M. Metzger ◽  
Karin Hoelzer ◽  
Edward J. Dubovi ◽  
...  
Keyword(s):  
Equine Herpesvirus ◽  
Herpesvirus Type ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1 ◽  
Canine Influenza

scholarly journals Evaluation of the vaccine potential of an equine herpesvirus type 1 vector expressing bovine viral diarrhea virus structural proteins

2007 ◽  
Vol 88 (3) ◽  
pp. 748-757 ◽  
Author(s):  
Cristina T. Rosas ◽  
Patricia König ◽  
Martin Beer ◽  
Edward J. Dubovi ◽  
B. Karsten Tischer ◽  
...  
Keyword(s):  
Bovine Viral Diarrhea Virus ◽  
Structural Proteins ◽  
Bovine Viral Diarrhea ◽  
Equine Herpesvirus ◽  
Herpesvirus Type ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Equine Herpesvirus Type 1 ◽  
Viral Diarrhea Virus

Bovine viral diarrhea virus (BVDV) is an economically important pathogen of cattle that is maintained in the population by persistently infected animals. Virus infection may result in reproductive failure, respiratory disease and diarrhoea in naïve, susceptible bovines. Here, the construction and characterization of a novel vectored vaccine, which is based on the incorporation of genes encoding BVDV structural proteins (C, Erns, E1, E2) into a bacterial artificial chromosome of the equine herpesvirus type 1 (EHV-1) vaccine strain RacH, are reported. The reconstituted vectored virus, rH_BVDV, expressed BVDV structural proteins efficiently and was indistinguishable from parental vector virus with respect to growth properties in cultured cells. Intramuscular immunization of seronegative cattle with rH_BVDV resulted in induction of BVDV-specific serum neutralizing and ELISA antibodies. Upon experimental challenge infection of immunized calves with the heterologous BVDV strain Ib SE5508, a strong anamnestic boost of the neutralizing-antibody response was observed in all vaccinated animals. Immunized animals presented with reduced viraemia levels and decreased nasal virus shedding, and maintained higher leukocyte counts than mock-vaccinated controls.

Late-Term Abortion, Stillbirth, and Neonatal Foal Death in Kyrgyzstan: First Isolation of Equine Herpesvirus Type 1 in the Country

2017 ◽  
Vol 51 ◽  
pp. 46-53
Author(s):  
Maksat Akhmedzhanov ◽  
Rysbek Nurgaziev ◽  
Jailobek Orozov ◽  
Irmgard Moser ◽  
Nikolaus Osterrieder ◽  
...  
Keyword(s):  
Equine Herpesvirus ◽  
Herpesvirus Type ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1
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