scholarly journals Inhaled nitric oxide and arterial oxygen tension in patients with chronic obstructive pulmonary disease and severe pulmonary hypertension

Thorax ◽  
1997 ◽  
Vol 52 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Y. Katayama ◽  
T. W. Higenbottam ◽  
M. J. Diaz de Atauri ◽  
G. Cremona ◽  
S. Akamine ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Hypertension ◽  
Pulmonary Disease ◽  
Oxygen Tension ◽  
Arterial Oxygen Tension ◽  
Arterial Oxygen ◽  
Chronic Obstructive ◽  
Severe Pulmonary Hypertension ◽  
Obstructive Pulmonary Disease

Phenotype of patients with severe pulmonary hypertension secondary to chronic obstructive pulmonary disease: A multicentre study

2020 ◽  
Author(s):  
Vania Cecilia Prudencio Ribera ◽  
Agueda Aurtenetxe Pérez ◽  
María Lorena Coronel ◽  
Carmen Pérez-Olivares Delgado ◽  
María José Cristo Ropero ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Hypertension ◽  
Multicentre Study ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Severe Pulmonary Hypertension ◽  
Obstructive Pulmonary Disease

Effect of Fenspiride on Pulmonary Function in the Rat and Guinea Pig

1995 ◽  
Vol 88 (3) ◽  
pp. 325-330 ◽  
Author(s):  
D. Bee ◽  
E. A. Laude ◽  
C. J. Emery ◽  
P. Howard
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Arterial Oxygen Tension ◽  
Whole Body ◽  
Arterial Oxygen ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Arterial Blood ◽  
Airways Resistance ◽  
Anti Inflammatory

1. Fenspiride is an anti-inflammatory agent that may have a role in reversible obstructive airways disease. Small, but significant, improvements have been seen in airways function and arterial oxygen tension in patients with mild chronic obstructive pulmonary disease. These changes have been attributed to the anti-inflammatory properties of the drug. However, airways function can be improved by other means, e.g. improved ventilation/perfusion ratio or reduced airways resistance. The possibility that fenspiride may have actions other than anti-inflammatory was investigated in two animal species. 2. In the rat, actions on the pulmonary circulation were investigated in the isolated perfused lung, but fenspiride proved to be a poor pulmonary vasodilator, showing only a small reversal of the raised pulmonary artery pressure induced by hypoxia. 3. Ventilation was measured in the anaesthetized rat using whole-body plethysmography. Fenspiride caused no increase in ventilation or changes in arterial blood gases. However, a profound hypotensive action was observed with high doses. 4. The possibility that a decrease in airways resistance (Raw) might occur with fenspiride was investigated in anaesthetized guinea pigs. Capsaicin (30 μmol/l) was used to increase baseline Raw through bronchoconstriction. Fenspiride gave a dose-dependent partial reversal of the raised Raw, and its administration by aerosol proved as efficacious as the intravenous route. In addition, the hypotensive side-effect found with intravenous injection was alleviated by aerosolized fenspiride. 5. An anti-bronchoconstrictor action of fenspiride could be one of the mechanisms involved in improving airways function and Pao2, seen in mild chronic obstructive pulmonary disease.

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