scholarly journals Effect of inhaled procaterol on cough receptor sensitivity to capsaicin in patients with asthma or chronic bronchitis and in normal subjects.

Thorax ◽  
1993 ◽  
Vol 48 (6) ◽  
pp. 615-618 ◽  
Author(s):  
M Fujimura ◽  
S Sakamoto ◽  
Y Kamio ◽  
T Bando ◽  
K Kurashima ◽  
...  
Keyword(s):  
Chronic Bronchitis ◽  
Normal Subjects ◽  
Receptor Sensitivity ◽  
Cough Receptor

Reversibility of Airways Obstruction in Chronic Bronchitis

1972 ◽  
Vol 42 (6) ◽  
pp. 725-733 ◽  
Author(s):  
T. W. Astin
Keyword(s):  
Muscle Contraction ◽  
Chronic Bronchitis ◽  
Lung Volume ◽  
Normal Subjects ◽  
Atropine Sulphate ◽  
Airways Obstruction ◽  
Chest Disease ◽  
Before And After ◽  
Airways Resistance ◽  
Intravenous Atropine

1. Airways resistance and lung volume were measured in twenty-five patients with chronic bronchitis and fifteen patients without chest disease before and after the inhalation of isoprenaline. Similar measurements were made on fourteen of these patients with chronic bronchitis and twelve other patients without chest disease before and after the intravenous injection of atropine sulphate. 2. There were significant decreases in airways resistance after isoprenaline inhalation and intravenous atropine both in patients with bronchitis and normal subjects but the decreases were greater in the patients with chronic bronchitis. 3. The decrease in resistance was proportional to the degree of initial airways resistance. 4. The results are considered to indicate that bronchial muscle contraction increases the airways resistance of patients with chronic bronchitis and contributes to the airways obstruction; its contribution increases with increasing severity of the condition. A significant part of the increased airways resistance in these patients is potentially reversible and nervously mediated.

Mechanism of transient nocturnal hypoxemia in hypoxic chronic bronchitis and emphysema

1985 ◽  
Vol 59 (6) ◽  
pp. 1698-1703 ◽  
Author(s):  
J. R. Catterall ◽  
P. M. Calverley ◽  
W. MacNee ◽  
P. M. Warren ◽  
C. M. Shapiro ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Chronic Bronchitis ◽  
Rem Sleep ◽  
Normal Subjects ◽  
Arterial Pco2 ◽  
Content Difference ◽  
Nocturnal Hypoxemia ◽  
Voluntary Hypoventilation ◽  
Arterial Po2 ◽  
Mixed Venous

In five patients with hypoxic chronic bronchitis and emphysema we measured ear O2 saturation (SaO2), chest movement, oronasal airflow, arterial and mixed venous gas tensions, and cardiac output during nine hypoxemic episodes (HE; SaO2 falls greater than 10%) in rapid-eye-movement (REM) sleep and during preceding periods of stable oxygenation in non-REM sleep. All nine HE occurred with recurrent short episodes of reduced chest movement, none with sleep apnea. The arterial PO2 (PaO2) fell by 6.0 +/- 1.9 (SD) Torr during the HE (P less than 0.01), but mean arterial PCO2 (PaCO2) rose by only 1.4 +/- 2.4 Torr (P greater than 0.4). The arteriovenous O2 content difference fell by 0.64 +/- 0.43 ml/100 ml of blood during the HE (P less than 0.05), but there was no significant change in cardiac output. Changes observed in PaO2 and PaCO2 during HE were similar to those in four normal subjects during 90 s of voluntary hypoventilation, when PaO2 fell by 12.3 +/- 5.6 Torr (P less than 0.05), but mean PaCO2 rose by only 2.8 +/- 2.1 Torr (P greater than 0.4). We suggest that the transient hypoxemia which occurs during REM sleep in patients with chronic bronchitis and emphysema could be explained by hypoventilation during REM sleep but that the importance of changes in distribution of ventilation-perfusion ratios cannot be assessed by presently available techniques.

scholarly journals Capsaicin cough receptor sensitivity test in children

1996 ◽  
Vol 9 (11) ◽  
pp. 2220-2223 ◽  
Author(s):  
A.B. Chang ◽  
P.D. Phelan ◽  
R.G.D. Roberts ◽  
C.F. Robertson
Keyword(s):  
Sensitivity Test ◽  
Receptor Sensitivity ◽  
Cough Receptor ◽  
Capsaicin Cough

Calculation of the VD/VT ratio by the helium washout technique

1986 ◽  
Vol 70 (6) ◽  
pp. 565-569 ◽  
Author(s):  
J. Jordanoglou ◽  
G. Tatsis ◽  
Z. Bissiouli
Keyword(s):  
Pulmonary Fibrosis ◽  
Chronic Bronchitis ◽  
Bronchial Asthma ◽  
Conventional Method ◽  
Normal Subjects

1. In four normal subjects and 51 patients with chronic bronchitis-emphysema, bronchial asthma and pulmonary fibrosis, the VD/VT ratio was measured by a helium washout technique (w VD/VT) and by the conventional Bohr's method using the arterial CO2 tension (VD/VT). 2. In 16 patients the w VD/VT ratio was compared with that calculated from Bohr's equation with the alveolar CO2 tension measured by the rebreathing technique (A VD/VT). 3. It was found that the values for the VD/VT ratio obtained by the helium washout technique were very close to those obtained by the conventional method using the Paco2 or P¯Aco2 values.

Pulmonary Blood Volume in Chronic Bronchitis

1977 ◽  
Vol 53 (6) ◽  
pp. 587-593
Author(s):  
B. Raffestin ◽  
H. Valette ◽  
J. L. Hebert ◽  
P. Duhaze ◽  
A. Lockhart
Keyword(s):  
Chronic Bronchitis ◽  
Blood Volume ◽  
Total Lung Capacity ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Sampling Technique ◽  
Normal Subjects ◽  
Pulmonary Blood Volume ◽  
Lung Capacity ◽  
Pulmonary Vasoconstriction ◽  
Mean Pressure

1. Pulmonary blood volume was measured in 39 patients with severe chronic bronchitis, of whom 29 had recently recovered from an acute exacerbation. Pa,o2 was below 10·3 kPa in all but five patients, Pa,co2 was above 5·6 kPa in 26 cases, and pulmonary artery mean pressure was above 20 mmHg in 29 cases. Pulmonary blood volume was measured with the double-injection—single-sampling technique using Indocyanine Green and pulmonary wedge injection. 2. Pulmonary blood volume in the 39 patients was significantly lower (343 ± 95 ml) than in a group of 16 normal subjects (469 ± 117 ml) studied previously by the same method. There was no correlation between pulmonary blood volume and driving pressure across the pulmonary circulation, or between pulmonary blood volume and Pa,o2. 3. Breathing 26–29% oxygen in 19 patients caused no significant changes in either pulmonary blood volume or pulmonary vascular resistance. Therefore the reduced pulmonary blood volume could not be attributed to hypoxic pulmonary vasoconstriction. 4. The finding of a diminished pulmonary blood volume in chronic bronchitis is best explained by a loss of pulmonary vessels. Pulmonary blood volume was not correlated with total lung capacity nor with the residual volume/total lung capacity ratio, nor was it significantly higher in the 16 patients with normal total lung capacity (352 ± 73 ml) than in the 23 patients with a total lung capacity greater than 110% of normal (331 ± 110 ml). There was therefore no correlation between the amount of emphysema and the reduction in pulmonary blood volume.

Increased Cough Receptor Sensitivity to Capsaicin Predicts a Positive Bronchial Thermoplasty Response

2019 ◽  
Vol 26 (2) ◽  
pp. 137-141
Author(s):  
Kenta Yamamura ◽  
Johsuke Hara ◽  
Noriyuki Ohkura ◽  
Miki Abo ◽  
Takashi Sone ◽  
...  
Keyword(s):  
Receptor Sensitivity ◽  
Bronchial Thermoplasty ◽  
Cough Receptor
Sign in / Sign up

Export Citation Format

Share Document