scholarly journals Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.

Thorax ◽  
1993 ◽  
Vol 48 (4) ◽  
pp. 324-329 ◽  
Author(s):  
K Rajakulasingam ◽  
R Polosa ◽  
L C Lau ◽  
M K Church ◽  
S T Holgate ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Nasal Airways ◽  
Airways Resistance

Nasal effects of bradykinin and capsaicin: influence on plasma protein leakage and role of sensory neurons

1992 ◽  
Vol 72 (4) ◽  
pp. 1418-1424 ◽  
Author(s):  
K. Rajakulasingam ◽  
R. Polosa ◽  
L. C. Lau ◽  
M. K. Church ◽  
S. T. Holgate ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Plasma Protein ◽  
Receptor Subtype ◽  
Vascular Effects ◽  
Double Blind ◽  
Nasal Airways ◽  
Relative Contribution ◽  
Airways Resistance ◽  
Sensory Neural

Nasal insufflation with bradykinin induces nasal discomfort, rhinorrhea, and nasal blockage, all features of rhinitis. We recently showed these effects to be mediated by the B2-receptor subtype, which has been identified at neural and vascular sites. To investigate the relative contribution of capsaicin-sensitive sensory neural stimulation to the action(s) of bradykinin, two randomized double-blind placebo-controlled studies have been undertaken comparing the nasal effects of single-dose administrations of bradykinin (1.88 x 10(-3) M) and capsaicin (3.28 x 10(-5) M). In comparison with placebo, both bradykinin and capsaicin induced nasal pain/discomfort (P less than 0.01) and rhinorrhea (P less than 0.02). Bradykinin significantly increased nasal airways resistance (P less than 0.005) and plasma protein exudation (P less than 0.02). No such changes were identified after nasal challenge with capsaicin. These findings suggest that bradykinin-induced nasal discomfort and rhinorrhea are neurally mediated, whereas the effects on nasal airways resistance and plasma protein exudation are due to a direct vascular action. In addition, these findings question the role of capsaicin-sensitive sensory neurons in nasal vasculature responses, because no vascular effects of capsaicin could be identified in the human nasal mucosa.

scholarly journals The temporal relationship between the neural and vascular actions of kallidin within the nose

1993 ◽  
Vol 2 (3) ◽  
pp. 217-223 ◽  
Author(s):  
K. Rajakulasingam ◽  
L. C. K. Lau ◽  
R. Polosa ◽  
M. K. Church ◽  
S. T. Holgate ◽  
...  
Keyword(s):  
Time Course ◽  
Post Challenge ◽  
Vascular Effects ◽  
Nasal Blockage ◽  
Nasal Airways ◽  
Protein Levels ◽  
Microvascular Leakage ◽  
Airways Resistance ◽  
Induced Changes ◽  
Sustained Increase

The time course of effect of the B2-receptor agonist kallidin (K) on induced changes of nasal airflow, rhinorrhoea, nasal pain, sneezing and nasal microvascular leakage has been examined and compared with its B2metabolite agonist bradykinin (B) and the B1-agonist [des-arg9]-bradykinin (D). When administered as a single dose K and B induced an immediate sensation of pain, rhinorrhoea, elevations in lavage albumin and protein levels and a sustained increase in nasal airways resistance (NAR) for 5–40 min post-challenge. [des-arg9]-Bradykinin and vehicle placebo (V) were without effect on any of these indices. These studies identify the action of K and B within the nose and differentiate the neural and vascular effects of these kinins in addition to suggesting the potential that nasal blockage and nasal microvascular leakage represent alterations in differing vascular compartments. These findings have implications for the understanding and therapeutic manipulation of rhinitis.

Comparison of oscillation with three other methods for measuring nasal airways resistance

1990 ◽  
Vol 84 (2) ◽  
pp. 101-106 ◽  
Author(s):  
D.M. Shelton ◽  
J. Pertuze ◽  
M.J. Gleeson ◽  
J. Thompson ◽  
W.T. Denman ◽  
...  
Keyword(s):  
Nasal Airways ◽  
Airways Resistance

Phase variation in nasal airways resistance assessed by active anterior rhinomanometry

1987 ◽  
Vol 101 (9) ◽  
pp. 910-916 ◽  
Author(s):  
G. S. Kenyon
Keyword(s):  
Statistical Significance ◽  
Phase Variation ◽  
Normal Subjects ◽  
Nasal Airways ◽  
Nasal Cycle ◽  
Significant Difference ◽  
Airways Resistance ◽  
Respiratory Phases ◽  
Active Anterior Rhinomanometry

AbstractMeasurements of nasal airways resistance in normal subjects have shown a significant difference between values obtained in the two respiratory phases. Higher overall values are found during expiration in both the unprepared and decongested nose but these differences fail to maintain statistical significance after application of a decongestant. This indicates that the phase of respiration in which measurement is made must be routinely recorded especially when measurement is made without decongestant, and comparisons of data made only with recordings from equivalent parts of the nasal cycle.

Do Rhinomanometric Findings Predict Subjective Postoperative Satisfaction? Long-term follow-up after Septoplasty

1993 ◽  
Vol 7 (2) ◽  
pp. 71-75 ◽  
Author(s):  
Jouko T. Suonpää ◽  
Jukka I. Sipilä ◽  
Pekka J. Laippala
Keyword(s):  
Allergic Rhinitis ◽  
Positive Response ◽  
Nasal Airways ◽  
Subjective Satisfaction ◽  
Spontaneous Course ◽  
Normal Resistance ◽  
Long Term Follow Up ◽  
Airways Resistance

Eighty-eight septoplasty patients were controlled with rhinomanometry 6 months after surgery and their subjective satisfaction was re-evaluated with a questionnaire 3–5 years after surgery. A slight but not statistically significant tendency for a decreasing level of subjective satisfaction was evident. The results show that patients whose nasal airways resistance was high preoperatively and patients who were normalized surgically were the most satisfied. The number of symptom-free patients was lower among those who were operated on with normal resistance, and in these cases it is suggested that the positive response is mainly a result of the spontaneous course of the chronic disease of nasal mucosa (e.g., allergic rhinitis), not a result of the operation. Preoperative rhinomanometry helps to select patients who benefit most from the surgery and thus, saves operative resources.

Airway Resistance during Esophageal Phonation

1982 ◽  
Vol 47 (2) ◽  
pp. 194-199 ◽  
Author(s):  
Bernd Weinberg ◽  
Yoshiyuki Horii ◽  
Eric Blom ◽  
Mark Singer
Keyword(s):  
Speech Production ◽  
Airway Resistance ◽  
Voice Restoration ◽  
Esophageal Speech ◽  
Airways Resistance ◽  
Restoration Method

Prosthesis airway resistance calculations were completed for five Blom-Singer prostheses and esophageal source airway resistance estimated were made of five laryngectomized patients using the Singer-Blom voice restoration method. Airway resistance of the Blom-Singer prostheses ranged from 46 to 121 cmH 2 O/LPS, while source airways resistance in these subjects ranged from about 155 to 270 cmH 2 O/LPS. These results revealed that the opposition of the voicing sources used in esophageal speech production to airflow through them is substantial and larger than that established for the normal, laryngeal source. Findings are interpreted to highlight major advantages the Singer-Blom (1980) method of speech/voice restoration has over esophageal speech/voice produced on a conventional basis and to reveal specific reasons for the failure of may laryngectomized patients to develop consistent voice and functionally serviceable speech.

Kinetics of Various 99mTc-Sn-Pyrophosphate Compounds in the Rat

1977 ◽  
Vol 16 (03) ◽  
pp. 100-103 ◽  
Author(s):  
C. Schümichen ◽  
J. Waiden ◽  
G. Hoffmann
Keyword(s):  
Glomerular Filtration ◽  
Renal Clearance ◽  
Plasma Protein ◽  
Kinetic Data ◽  
Adult Rats ◽  
Compound A ◽  
Extravascular Space ◽  
Tubular Cells ◽  
Glomerular Filtrate ◽  
Kinetics Of

SummaryThe kinetic data of two different 99mTc-Sn-pyrophosphate compounds (compound A and B) were evaluated in non-adult rats. Only compound A concentrated in bone. Both compounds dispersed rapidly in the intravascular as well as the extravascular space. The plasma protein bond of both compounds increased with time after injection and impaired both the renal clearance of both compounds and the bone clearance of compound A. The renal clearance of both compounds was somewhat above that of 5 1Cr-EDTA. It is concluded that compound A and B is mainly excreted by glomerular filtration. About one fourth of the glomerular filtrate of compound B is reabsorbed and accumulated by the tubular cells.

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