scholarly journals High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening

Thorax ◽  
2011 ◽  
Vol 66 (8) ◽  
pp. 669-673 ◽  
Author(s):  
T. Oni ◽  
R. Burke ◽  
R. Tsekela ◽  
N. Bangani ◽  
R. Seldon ◽  
...  
Keyword(s):  
Advanced Immunodeficiency ◽  
High Prevalence ◽  
Hiv 1

scholarly journals High Prevalence and Onward Transmission of Non-Pandemic HIV-1 Subtype B Clades in Northern and Northeastern Brazilian Regions

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162112 ◽  
Author(s):  
Flavia Divino ◽  
Andre de Lima Guerra Corado ◽  
Felipe Gomes Naveca ◽  
Mariane M. A. Stefani ◽  
Gonzalo Bello
Keyword(s):  
Subtype B ◽  
High Prevalence ◽  
Hiv 1

High prevalence of primary Enfuvirtide (ENF) resistance-associated mutations in HIV-1-infected patients in Hong Kong

2010 ◽  
Vol 47 (3) ◽  
pp. 273-275 ◽  
Author(s):  
P.H.M. Leung ◽  
J.H.K. Chen ◽  
K.H. Wong ◽  
K.C. Chan ◽  
H.Y. Lam ◽  
...  
Keyword(s):  
Hong Kong ◽  
High Prevalence ◽  
Hiv 1

scholarly journals HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting

2019 ◽  
Vol 18 ◽  
pp. 232595821984906
Author(s):  
Nawaid Hussain Khan ◽  
Mikashmi Kohli ◽  
Kartik Gupta ◽  
Bimal Kumar Das ◽  
Ravindra Mohan Pandey ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Drug Resistant ◽  
Resistance Mutations ◽  
Reverse Transcriptase Inhibitors ◽  
Nucleoside Reverse Transcriptase Inhibitors ◽  
First Line Therapy ◽  
Resource Limited ◽  
High Prevalence ◽  
Hiv 1 ◽  
Limited Setting

Introduction: The present study aimed to report the prevalent HIV-1 drug-resistant mutations in patients with HIV-1 alone and tuberculosis (TB) coinfection alone to improve our understanding of the mutation patterns and aid treatment decisions. Methods: Patients with HIV-1 and HIV-TB on treatment for more than 1 year with suspected failure were recruited. Sequencing of protease and two-thirds of the region of reverse transcriptase gene was done for drug-resistant mutations. Results: In the HIV-TB group (n = 25), 88%, 92%, and 12% had mutations to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), respectively. In the HIV-alone group (n = 25), 84%, 100%, and 4% had mutations to NRTIs, NNRTIs, and PIs, respectively. M184V, M41L, D67N, G190A, A98G, and K103N were the most common mutations seen. Conclusion: There is a high prevalence of drug-resistant mutations in HIV and HIV-TB coinfected patients.

Characterization of drug resistance and the defective HIV reservoir in virally suppressed vertically infected children in Mali

2020 ◽  
Vol 75 (5) ◽  
pp. 1272-1279
Author(s):  
Josephine Brice ◽  
Mariam Sylla ◽  
Nathalie Desire ◽  
Sophie Sayon ◽  
Fatoumata Telly ◽  
...  
Keyword(s):  
Stop Codon ◽  
Dried Blood Spots ◽  
Viral Population ◽  
Genotypic Resistance ◽  
Hiv Reservoir ◽  
Hiv Dna ◽  
Art Initiation ◽  
High Prevalence ◽  
Resistance Patterns ◽  
Hiv 1

Abstract Background In the perspective of ART-free HIV remission, vertically infected children treated with suppressive ART from early infancy represent an optimal population model to better understand the genetic complexity of the reservoir. Objectives To evaluate the proportion of defective viral population and the genotypic resistance patterns in cell-associated HIV DNA. Methods In a cohort including 93 ART-treated vertically HIV-infected (VHIV) children in Mali with plasma HIV-1 RNA ≤50 copies/mL for at least 6 months, we studied total HIV DNA, percentage of defective genomes and resistance by reverse transcriptase and protease bulk sequencing from whole blood in dried blood spots. Results Children had a median age of 9.9 years at the time of inclusion (IQR = 7.6–13.4) and 3.3 years (IQR = 2–7) at ART initiation; median ART duration was 5.5 years (IQR = 3.7–7.3). The median level of total HIV DNA was 470 copies/106 cells with one patient presenting undetectable HIV DNA (<66 copies/106 cells). We observed the presence of at least one stop codon in viruses from 34 patients (37%). The presence of stop codons was not correlated with the level of HIV DNA or duration of ART. We showed a high prevalence of HIV-1 resistance in DNA with 26% of children harbouring virus resistant to at least one NRTI and 40% to at least one NNRTI. Conclusions While these VHIV children were successfully treated for a long time, they showed high prevalence of resistance in HIV DNA and a moderate defective HIV reservoir.

High Prevalence of Sequences Included in Transmission Clusters Within Newly Diagnosed HIV-1 Patients in Southern Spain (2004–2015)

2020 ◽  
Vol 26 (9) ◽  
pp. 1090-1097
Author(s):  
Carmen M. González-Domenech ◽  
Gabriel Sena-Corrales ◽  
Isabel Viciana-Ramos ◽  
Rosario Palacios-Muñoz ◽  
Laura Mora-Navas ◽  
...  
Keyword(s):  
Southern Spain ◽  
Newly Diagnosed ◽  
High Prevalence ◽  
Hiv 1

scholarly journals High prevalence and incidence of HIV-1 in a counseling and testing center in the city of Itajaí, Brazil

2015 ◽  
Vol 19 (6) ◽  
pp. 631-635 ◽  
Author(s):  
Gorki Grinberg ◽  
Leila Bertoni Giron ◽  
Rosalie Kupka Knoll ◽  
Juliana Galinskas ◽  
Michelle Camargo ◽  
...  
Keyword(s):  
Counseling And Testing ◽  
High Prevalence ◽  
Testing Center ◽  
The City ◽  
Hiv 1

scholarly journals High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Kah Ying Ng ◽  
Kuan Kiat Chew ◽  
Palvinder Kaur ◽  
Joe Yap Kwan ◽  
Wei Xin Khong ◽  
...  
Keyword(s):  
Cxcr4 Usage ◽  
High Prevalence ◽  
Treatment Naïve ◽  
Hiv 1
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