scholarly journals Role of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model

Thorax ◽  
2007 ◽  
Vol 62 (6) ◽  
pp. 527-535 ◽  
Author(s):  
J.-S. Jerng ◽  
Y.-C. Hsu ◽  
H.-D. Wu ◽  
H.-Z. Pan ◽  
H.-C. Wang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Rat Model ◽  
Renin Angiotensin System ◽  
In Vivo Study ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Ventilator Induced Lung Injury

ROLE OF RENIN-ANGIOTENSIN SYSTEM IN RADIATION-INDUCED LUNG INJURY

CHEST Journal ◽  
2008 ◽  
Vol 134 (4) ◽  
pp. 127P ◽  
Author(s):  
Rade Tomic ◽  
Elizabeth Jacobs ◽  
Metha Medhora ◽  
Andreea Antonescu-Turcu ◽  
Ghosh Swarajit
Keyword(s):  
Lung Injury ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Radiation Induced

The renin–angiotensin system in a rat model of hepatic fibrosis: Evidence for a protective role of Angiotensin-(1–7)

2007 ◽  
Vol 46 (4) ◽  
pp. 674-681 ◽  
Author(s):  
Regina Maria Pereira ◽  
Robson Augusto Souza dos Santos ◽  
Mauro Martins Teixeira ◽  
Virginia Hora Rios Leite ◽  
Lincoln Paiva Costa ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Rat Model ◽  
Renin Angiotensin System ◽  
Protective Role ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study

Life Sciences ◽  
2020 ◽  
Vol 257 ◽  
pp. 118067
Author(s):  
Thaiany G. Souza-Silva ◽  
Diego F. Vilas-Boas ◽  
Elda Gonçalves-Santos ◽  
Ana Lia Mazzeti ◽  
Ivo S. Caldas ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
In Vivo Study ◽  
Diminazene Aceturate ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection

2020 ◽  
Vol Volume 13 ◽  
pp. 3715-3725 ◽  
Author(s):  
Yan-Lei Gao ◽  
Yue Du ◽  
Chao Zhang ◽  
Cheng Cheng ◽  
Hai-Yan Yang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Viral Infection ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Serotoninergic stimulation of aldosterone secretion in the rat in vivo: role of the renin-angiotensin system

1991 ◽  
Vol 130 (3) ◽  
pp. 347-355 ◽  
Author(s):  
E. Davies ◽  
S. Rossiter ◽  
C. R. W. Edwards ◽  
B. C. Williams
Keyword(s):  
Enzyme Inhibitor ◽  
Direct Action ◽  
Renin Angiotensin System ◽  
Aldosterone Secretion ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Corticosterone Secretion ◽  
Sodium And Potassium

ABSTRACT Serotoninergic control of aldosterone secretion in vivo was investigated in conscious rats with indwelling arterial cannulae. Serial blood samples were taken from the animals before and after i.p. administration of 1 ml (4 g/l) 5-hydroxytryptophan (5-HTP), the precursor of serotonin, or saline and they were analysed for 5-HTP, serotonin, 5-hydroxyindoleacetic acid, plasma renin activity (PRA), corticosterone, aldosterone, sodium and potassium concentrations. The role of the renin-angiotensin system was investigated in animals pretreated for 1 week with the angiotensin-converting enzyme inhibitor captopril (25 mg/day). 5-HTP caused a significant increase in all parameters within 45 min except for sodium and potassium. Saline administration showed no significant effect. Captopril pretreatment did not impair the increase in any parameter by 5-HTP, with the exception of the aldosterone response which was significantly attenuated, though not completely. The results show that administration of 5-HTP, which increases serum serotonin levels, stimulates PRA, aldosterone and corticosterone secretion. Captopril pretreatment inhibits the aldosterone response, suggesting that the aldosterone stimulatory properties of 5-HTP require the presence of angiotensin II, although it is unclear whether it acts in a mediatory or permissive capacity. The failure of captopril to inhibit the aldosterone response completely suggests the involvement of other mechanisms such as the hypothalamo-pituitary adrenal axis or a direct action of serotonin on the adrenal. Journal of Endocrinology (1991) 130, 347–355

Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal disease

2001 ◽  
Vol 21 (6) ◽  
pp. 580-592 ◽  
Author(s):  
Arnold Boonstra ◽  
Dick de Zeeuw ◽  
Paul E. de Jong ◽  
Gerjan Navis
Keyword(s):  
Genetic Variability ◽  
Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

The Renin Angiotensin System and Bipolar Disorder: A Systematic Review

2020 ◽  
Vol 27 (6) ◽  
pp. 520-528 ◽  
Author(s):  
Izabela Guimarães Barbosa ◽  
Giulia Campos Ferreira ◽  
Diomildo Ferreira Andrade Júnior ◽  
Cássio Rocha Januário ◽  
André Rolim Belisário ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Cardiovascular Diseases ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Angiotensin Receptors ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Search Terms

Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.

The renin-angiotensin system in kidney development: role of COX-2 and adrenal steroids

2004 ◽  
Vol 181 (4) ◽  
pp. 549-559 ◽  
Author(s):  
B. L. Jensen ◽  
J. Stubbe ◽  
K. Madsen ◽  
F. T. Nielsen ◽  
O. Skott
Keyword(s):  
Kidney Development ◽  
Renin Angiotensin System ◽  
Adrenal Steroids ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Cox 2
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