scholarly journals How should COPD patients exercise during respiratory rehabilitation? Comparison of exercise modalities and intensities to treat skeletal muscle dysfunction

Thorax ◽  
2005 ◽  
Vol 60 (5) ◽  
pp. 367-375 ◽  
Author(s):  
M A Puhan
Keyword(s):  
Skeletal Muscle ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
Copd Patients ◽  
Respiratory Rehabilitation

scholarly journals Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Ákos Tényi ◽  
Isaac Cano ◽  
Francesco Marabita ◽  
Narsis Kiani ◽  
Susana G. Kalko ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
Copd Patients ◽  
Network Modules

Role of autophagy in COPD skeletal muscle dysfunction

2013 ◽  
Vol 114 (9) ◽  
pp. 1273-1281 ◽  
Author(s):  
Sabah N. A. Hussain ◽  
Marco Sandri
Keyword(s):  
Skeletal Muscle ◽  
Protein Degradation ◽  
Muscle Mass ◽  
Skeletal Muscles ◽  
Airflow Limitation ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
Copd Patients ◽  
Lung Dysfunction

Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by parenchymal damage and irreversible airflow limitation. In addition to lung dysfunction, patients with COPD develop weight loss, malnutrition, poor exercise performance, and skeletal muscle atrophy. The latter has been attributed to an imbalance between muscle protein synthesis and protein degradation. Several reports have confirmed that enhanced protein degradation and atrophy of limb muscles of COPD patient is mediated in part through activation of the ubiquitin-proteasome pathway and that this activation is triggered by enhanced production of reactive oxygen species. Until recently, the importance of the autophagy-lysosome pathway in protein degradation of skeletal muscles has been largely ignored, however, recent evidence suggests that this pathway is actively involved in recycling of cytosolic proteins, organelles, and protein aggregates in normal skeletal muscles. The protective role of autophagy in the regulation of muscle mass has recently been uncovered in mice with muscle-specific suppression of autophagy. These mice develop severe muscle weakness, atrophy, and decreased muscle contractility. No information is yet available about the involvement of the autophagy in the regulation of skeletal muscle mass in COPD patients. Pilot experiments on vastus lateralis muscle samples suggest that the autophagy-lysosome system is induced in COPD patients compared with control subjects. In this review, we summarize recent progress related to molecular structure, regulation, and roles of the autophagy-lysosome pathway in normal and diseased skeletal muscles. We also speculate about regulation and functional importance of this system in skeletal muscle dysfunction in COPD patients.

Skeletal muscle dysfunction among COPD patients in Eastern Europe

2020 ◽  
Author(s):  
Vitalii Poberezhets ◽  
Szymon Skoczyński ◽  
Anna Demchuk ◽  
Aleksandra Oraczewska ◽  
Ewelina Tobiczyk ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Eastern Europe ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
Copd Patients

scholarly journals S143 Premature Ageing And Skeletal Muscle Dysfunction In Copd Patients: Development Of A Cell Culture Model

Thorax ◽  
2014 ◽  
Vol 69 (Suppl 2) ◽  
pp. A76-A76
Author(s):  
R. Lahkdar ◽  
G. Choudhury ◽  
J. McLeish ◽  
E. Drost ◽  
L. McGlynn ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Culture ◽  
Muscle Dysfunction ◽  
Cell Culture Model ◽  
Premature Ageing ◽  
Skeletal Muscle Dysfunction ◽  
Copd Patients ◽  
Culture Model ◽  
A Cell

Impact of comorbidities on the deterioration of skeletal muscle dysfunction among COPD patients

2020 ◽  
Author(s):  
Vitalii Poberezhets ◽  
Szymon Skoczyński ◽  
Anna Demchuk ◽  
Aleksandra Oraczewska ◽  
Ewelina Tobiczyk ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Dysfunction ◽  
Skeletal Muscle Dysfunction ◽  
Copd Patients
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