scholarly journals Prevalence and clonality of Burkholderia cepacia complex genomovars in UK patients with cystic fibrosis referred for lung transplantation

Thorax ◽  
2004 ◽  
Vol 59 (6) ◽  
pp. 526-528 ◽  
Author(s):  
A De Soyza
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Burkholderia Cepacia ◽  
Burkholderia Cepacia Complex

Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime–avibactam

Infection ◽  
2018 ◽  
Vol 47 (2) ◽  
pp. 289-292 ◽  
Author(s):  
Ibai Los-Arcos ◽  
Oscar Len ◽  
María Teresa Martín-Gómez ◽  
Juan José González-López ◽  
Berta Saéz-Giménez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Burkholderia Cepacia ◽  
Burkholderia Cepacia Complex

scholarly journals Bacterial Re-Colonization Occurs Early after Lung Transplantation in Cystic Fibrosis Patients

2021 ◽  
Vol 10 (6) ◽  
pp. 1275
Author(s):  
Anna Engell Holm ◽  
Hans Henrik Lawaetz Schultz ◽  
Helle Krogh Johansen ◽  
Tania Pressler ◽  
Thomas Kromann Lund ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Burkholderia Cepacia ◽  
Bacterial Species ◽  
Positive Culture ◽  
Burkholderia Cepacia Complex ◽  
Achromobacter Xylosoxidans ◽  
Lung Function Decline ◽  
Before And After ◽  
The Impact

Most cystic fibrosis (CF) patients referred for lung transplantation are chronically infected with Gram-negative opportunistic pathogens. It is well known that chronic infections in CF patients have a significant impact on lung-function decline and survival before transplantation. The rate and timing of re-colonization after transplantation have been described, but the impact on survival after stratification of bacteria is not well elucidated. We did a single-center retrospective analysis of 99 consecutive CF patients who underwent lung transplantation since the beginning of the Copenhagen Lung Transplant program in 1992 until October 2014. Two patients were excluded due to re-transplantation. From the time of CF diagnosis, patients had monthly sputum cultures. After transplantation, CF-patients had bronchoscopy with bronchoalveolar lavage at 2, 4, 6 and 12 weeks and 6, 12, 18 and 24 months after transplantation, as well as sputum samples if relevant. Selected culture results prior to and after transplantation were stored. We focused on colonization with the most frequent bacteria: Pseudomonas aeruginosa (PA), Stenotrophomonas maltophilia (SM), Achromobacter xylosoxidans (AX) and Burkholderia cepacia complex (BCC). Pulsed-field gel electrophoresis (PFGE) was used to identify clonality of bacterial isolates obtained before and after lung transplantation. Time to re-colonization was defined as the time from transplantation to the first positive culture with the same species. Seventy-three out of 97 (75%) had sufficient culture data for analyses with a median of 7 (1–91) cultures available before and after transplantation. Median colonization-free survival time was 23 days until the first positive culture after transplantation. After 2 years, 59 patients (81%) were re-colonized, 33 (48.5%) with PA, 7 (10.3%) with SM, 12 (17.6%) with AX, and 7 (10.3%) with BCC. No difference in survival was observed between the patients colonized within the first 2 years and those not colonized. Re-colonization of bacteria in the lower airways occurred at a median of 23 days after transplantation in our cohort. In our patient cohort, survival was not influenced by re-colonization or bacterial species.

Lung transplantation for patients with cystic fibrosis and Burkholderia cepacia complex infection: A single-center experience

2010 ◽  
Vol 29 (12) ◽  
pp. 1395-1404 ◽  
Author(s):  
Anthony De Soyza ◽  
Gerard Meachery ◽  
Katy L.M. Hester ◽  
Audrey Nicholson ◽  
Gareth Parry ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Burkholderia Cepacia ◽  
Burkholderia Cepacia Complex ◽  
Single Center ◽  
Single Center Experience

scholarly journals Survival After Lung Transplantation of Cystic Fibrosis Patients Infected with Burkholderia cepacia Complex

2008 ◽  
Vol 8 (5) ◽  
pp. 1025-1030 ◽  
Author(s):  
B. D. Alexander ◽  
E. W. Petzold ◽  
L. B. Reller ◽  
S. M. Palmer ◽  
R. D. Davis ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Burkholderia Cepacia ◽  
Burkholderia Cepacia Complex
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