scholarly journals Is serum gamma-glutamyl transferase a good marker of alcohol intake in stroke patients?

1990 ◽  
Vol 66 (779) ◽  
pp. 710-713 ◽  
Author(s):  
K. Peck ◽  
R. Shinton ◽  
G. Beevers
Keyword(s):  
Alcohol Intake ◽  
Gamma Glutamyl Transferase ◽  
Stroke Patients ◽  
Gamma Glutamyl ◽  
Good Marker ◽  
Glutamyl Transferase

scholarly journals Increased concentration of serum gamma-glutamyl transferase in ischemic stroke patients

2021 ◽  
Vol 7 (2) ◽  
pp. 71
Author(s):  
Pinki Tak ◽  
TejaRam Kalirawna ◽  
Jitendra Rohilla ◽  
ShyamSunder Bairwa ◽  
SunilKumar Gothwal ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Stroke Patients ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals The association of alcohol intake with gamma-glutamyl transferase (GGT) levels: Evidence for correlated genetic effects

2014 ◽  
Vol 134 ◽  
pp. 99-105 ◽  
Author(s):  
Jenny H.D.A. van Beek ◽  
Marleen H.M. de Moor ◽  
Lot M. Geels ◽  
Michel R.T. Sinke ◽  
Eco J.C. de Geus ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Genetic Effects ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Serum gamma-glutamyl transferase level in acute stroke

2019 ◽  
Vol 7 (8) ◽  
pp. 2950
Author(s):  
Lagendra Kumar Singh ◽  
Sourabh Pradhan ◽  
Laxmikanta Dash ◽  
Jagannath Pradhan ◽  
Umakanta Raul ◽  
...  
Keyword(s):  
Standard Deviation ◽  
General Medicine ◽  
First Episode ◽  
P Value ◽  
Gamma Glutamyl Transferase ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
The Mean ◽  
Glutamyl Transferase

Background: Stroke is the second leading cause of death worldwide, causing 6.2 million deaths in 2011. Serum Gamma-Glutamyl Transferase (GGT) has been conventionally considered as a marker of excessive alcohol intake and/or liver dysfunction. There are accumulating evidences suggesting association of raised serum GGT level in stroke. So, this study was conducted to determine the association between the serum GGT level and stroke in population without history of alcohol consumption.Methods: This cross-sectional comparative study was carried out at Department of General medicine, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla from November 2016 to October 2018. 100 cases and 100 controls were included in this study. Cases were the patients admitted to Department of General Medicine, VIMSAR, Burla, presenting within 24 hours of first episode of stroke. Controls were the age (+/-5 years) and sex matched healthy attendants of the patients. Alcoholics or patients suffering from hepatitis, cirrhosis of liver, cholestasis or patients taking drugs like Phenytoin, Valproic acid, Carbamazepine etc or patients with past episode of stroke were excluded from this study. Serum GGT level of both cases and controls were measured and compared.Results: In stroke patients, the mean serum GGT level was 54.95 IU/L with standard deviation of 20.54. In controls, the mean serum GGT level was 32.14 IU/L with standard deviation of 5.07. The p-value was less than 0.0001 i.e. highly significant.Conclusions: Serum GGT level is significantly increased in stroke patients than healthy persons without stroke.

scholarly journals Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Esmée M. Bijnens ◽  
Catherine Derom ◽  
Evert Thiery ◽  
Dries S. Martens ◽  
Ruth J. F. Loos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcohol Consumption ◽  
Telomere Length ◽  
Young Adulthood ◽  
Alcohol Intake ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

AbstractStudies based on self-reported alcohol consumption and telomere length show inconsistent results. Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. The possible health relevance in young adulthood was explored by investigating cardiometabolic risk factors. Mixed modelling was performed to examine GGT and alcohol consumption in association with telomere length in buccal cells of 211 adults between 18 and 30 years old of the East Flanders Prospective Twin Survey. In addition, we investigated the association between GGT and cardiometabolic risk factors; waist circumference, systolic blood pressure, fasting glucose, HDL cholesterol, and triglycerides. Although we did not observe an association between self-reported alcohol consumption and telomere length, our results show that a doubling in serum GGT is associated with 7.80% (95% CI − 13.9 to − 1.2%; p = 0.02) shorter buccal telomeres, independently from sex, chronological age, educational level, zygosity and chorionicity, waist-to-hip ratio and smoking. The association between GGT was significant for all five cardiometabolic risk factors, while adjusting for age. We show that GGT, a widely used biomarker of alcohol consumption, is associated with telomere length and with risk factors of cardiometabolic syndrome, despite the young age of this study population.

Gamma-Glutamyl Transferase: A Useful Marker of Habitual Drinking in Cases of Alcohol-Associated Osteonecrosis of the Femoral Head

2020 ◽  
Author(s):  
Hidetoshi Hamada ◽  
Wataru Ando ◽  
Masaki Takao ◽  
Nobuhiko Sugano
Keyword(s):  
Femoral Head ◽  
Alcohol Intake ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Median Serum ◽  
Glutamyl Transferase ◽  
Epidemiological Information

Abstract Aims Alcohol intake is one of the factors associated with the occurrence of osteonecrosis of the femoral head (ONFH), and its epidemiological information regarding alcohol intake depends on patients’ self-reports. Therefore, we analysed the efficacy of laboratory tests as an objective diagnostic tool to indicate habitual drinking in patients with alcohol-associated ONFH. Methods This study included 109 consecutive patients diagnosed with ONFH who underwent primary hip surgery in our institution between 2010 and 2018. The patients were classified into group AL (alcohol-associated ONFH; n = 26) and group NO (alcohol-unassociated ONFH; n = 83), based on their self-reported information. Serum levels of gamma-glutamyl transferase (GGT), mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol and triglycerides were compared between both groups. The sensitivities and specificities with the optimal cut-off values for detecting alcohol-associated ONFH were compared among these markers. Results The median serum levels of GGT, AST and ALT were significantly higher in the AL group than in the NO group. The receiver operating characteristic curve analysis demonstrated an area under the curve of 0.795 for GGT, 0.731 for AST and 0.709 for ALT. The optimal cut-off level of GGT as a marker for alcohol-associated ONFH was 36.5 units/L, with a sensitivity of 76% and specificity of 80%, and it was found to be the best marker among the other examined laboratory markers. Conclusion Serum GGT level is a useful laboratory marker with moderate accuracy that indicates habitual drinking in patients with alcohol-associated ONFH.

Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease

2016 ◽  
Vol 49 (15) ◽  
pp. 1127-1132 ◽  
Author(s):  
Gjin Ndrepepa ◽  
Roisin Colleran ◽  
Anke Luttert ◽  
Siegmund Braun ◽  
Salvatore Cassese ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Value ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Patients With Diabetes ◽  
Artery Disease ◽  
Glutamyl Transferase

Bước đầu khảo sát sự ổn định của một số chỉ số xét nghiệm sinh hóa trong máu toàn phần và huyết tương theo thời gian bảo quản mẫu bệnh phẩm

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Đinh Thị Thảo ◽  
Trần Thái Hà ◽  
Nguyễn Viết Tân ◽  
Vi Thị Nhung ◽  
Nguyễn Cẩm Thạch
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Mau Mau ◽  
Glutamyl Transferase

Mục tiêu: Đánh giá ảnh hưởng của thời gian bảo quản đến kết quả phân tích các chỉ số urea, creatinine, triglycerid, cholesterol, HDL-cholesterol, LDL-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), acid uric, bilirubin toàn phần, bilirubin trực tiếp trong mẫu máu toàn phần và huyết tương. Đối tượng và phương pháp: Gồm 162 mẫu máu toàn phần được chống đông bằng Li-heparin của 81 bệnh nhân (mỗi bệnh nhân lấy 2 ống mẫu) đến khám tại Khoa Khám bệnh - Bệnh viện Trung ương Quân đội 108 từ ngày 15/01/2021 đến ngày 15/02/2021. Với mỗi bệnh nhân: Ngay sau khi lấy máu, ống mẫu 1 được ly tâm, phân tích thường quy các chỉ số hóa sinh (phần còn lại sau phân tích gọi là mẫu 1), ống mẫu 2 được tách lấy huyết tương (mẫu 2). Sau đó, cả 2 mẫu được lưu trong tủ lạnh ở nhiệt độ 4oC. Sử dụng các mẫu này để phân tích các chỉ số hóa sinh tại các thời điểm 24, 48, và 72 giờ sau khi lấy máu. Kết quả: Nồng độ AST của các mẫu 1 được lưu trong 24, 48, 72 giờ cao hơn nồng độ AST phân tích thường quy (p<0,05). Nồng độ bilirubin toàn phần, bilirubin trực tiếp của mẫu 1 và mẫu 2 giảm dần theo thời gian lưu mẫu (p<0,05). Kết luận: Nồng độ các chỉ số AST, bilirubin toàn phần, bilirubin trực tiếp của các mẫu lưu (huyết tương và mẫu máu sau phân tích không loại bỏ các thành phần hữu hình) không ổn định theo thời gian bảo quản ở 4oC. Nồng độ các chỉ số urea, creatinine, triglycerid, cholesterol, HDL-cholesterol, LDL-cholesterol, ALT, GGT, acid uric (huyết tương và mẫu máu sau phân tích không loại bỏ các thành phần hữu hình) ổn định đến 72 giờ ở 4oC. Từ khóa: Hóa sinh, bảo quản bệnh phẩm, Bệnh viện Trung ương Quân đội 108.

P70 Gamma Glutamyl Transférase (GGT) et syndrome métabolique à la Réunion- Données issues de la cohorte REDIA 1

2008 ◽  
Vol 34 ◽  
pp. H63
Author(s):  
N. Le Moullec ◽  
A. Fianu ◽  
X. Debussche ◽  
C. Le Pommelet ◽  
M.C. Boyer ◽  
...  
Keyword(s):  
Syndrome Métabolique ◽  
Gamma Glutamyl Transferase ◽  
La Réunion ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase
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