scholarly journals An XO-X ring X chromosome mosaicism in an individual with normal secondary sexual development.

1966 ◽  
Vol 3 (2) ◽  
pp. 129-133 ◽  
Author(s):  
A M Bishop ◽  
C E Blank ◽  
K Simpson ◽  
C J Dewhurst
Keyword(s):  
X Chromosome ◽  
Sexual Development ◽  
Chromosome Mosaicism ◽  
Secondary Sexual

scholarly journals Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Weiyin Zhou ◽  
Shu-Hong Lin ◽  
Sairah M. Khan ◽  
Meredith Yeager ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
X Chromosome ◽  
Gene Dosage ◽  
Large Population ◽  
Population Based ◽  
Chromosome X ◽  
Genotyping Array ◽  
Chromosome Mosaicism ◽  
Age Related ◽  
Leukocyte Function ◽  
Peripheral Leukocytes

AbstractAge-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a population-based survey of 196,219 UK Biobank men. We detected 12 (0.006%) men with mosaic chromosome X gains ≥ 2 Mb and found no evidence for mosaic chromosome X loss, a level of detection substantially lower than for autosomes or other sex chromosomes. The rarity of chromosome X mosaicism in males relative to females reflects the importance of chromosome X gene dosage for leukocyte function.

scholarly journals Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development

2008 ◽  
Vol 237 (10) ◽  
pp. 2963-2972 ◽  
Author(s):  
Xi Wang ◽  
Nishita Desai ◽  
Ya-Ping Hu ◽  
Sandy M. Price ◽  
Cory Abate-Shen ◽  
...  
Keyword(s):  
Sexual Development ◽  
Secondary Sexual

PRECOCIOUS GROWTH OF SEXUAL HAIR WITHOUT OTHER SECONDARY SEXUAL DEVELOPMENT; "PREMATURE PUBARCHE," A CONSTITUTIONAL VARIATION OF ADOLESCENCE

PEDIATRICS ◽  
1952 ◽  
Vol 10 (4) ◽  
pp. 426-432
Author(s):  
SAMUEL H. SILVERMAN ◽  
CLAUDE MIGEON ◽  
EUGENIA ROSEMBERG ◽  
LAWSON WILKINS
Keyword(s):  
Sexual Development ◽  
Present Report ◽  
Bone Age ◽  
Vaginal Smears ◽  
Laboratory Findings ◽  
Sexual Precocity ◽  
Precocious Adrenarche ◽  
Premature Pubarche ◽  
Urinary Estrogens ◽  
Secondary Sexual

GROWTH of sexual hair in a young child suggests the possibility that adrenal tumor or hyperplasia may be causing virilization or that true sexual precocity may be beginning. However, neither of these relatively serious conditions may exist. Approximately 10 years ago workers in the Endocrine Clinic of the Harriet Lane Home became aware of the fact that sexual hair may appear in early life long before there is any other secondary sexual development dependent upon either androgen or estrogen. Although this syndrome has been referred to briefly in textbooks as "precocious adrenarche" and "premature pubarche," no detailed studies of a series of cases have been recorded. The present report is based on a study of 29 children who developed sexual hair before the age of 8 years. It was possible to follow a number of these patients long enough to demonstrate that the condition is a benign variation in the pattern of sexual development and is followed later by normal adolescence. It seems important to bring the findings to the attention of pediatricians who may not be familiar with the syndrome and to discuss its differential diagnosis and probable etiology. Methods Urinary 17-ketosteroids (17-KS) were determined by a modification of the method of Callow, Callow and Emmons previously described, urinary estrogens were measured as the "fluorogenic phenols" by the method of Jailer. Vaginal smears stained by the method of Shorr were interpreted as described elsewhere. The "bone age" was based on the average epiphysial development at all the joints. Clinical and Laboratory Findings

scholarly journals Cryptic Subtelomeric Rearrangements and X Chromosome Mosaicism: A Study of 565 Apparently Normal Individuals with Fluorescent In Situ Hybridization

PLoS ONE ◽  
2009 ◽  
Vol 4 (6) ◽  
pp. e5855 ◽  
Author(s):  
Jasen L. Wise ◽  
Richard J. Crout ◽  
Daniel W. McNeil ◽  
Robert J. Weyant ◽  
Mary L. Marazita ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
X Chromosome ◽  
Fluorescent In Situ Hybridization ◽  
Chromosome Mosaicism ◽  
Normal Individuals ◽  
Subtelomeric Rearrangements

scholarly journals Cytogenetics of Premature Ovarian Failure: An Investigation on 269 Affected Women

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Simona Baronchelli ◽  
Donatella Conconi ◽  
Elena Panzeri ◽  
Angela Bentivegna ◽  
Serena Redaelli ◽  
...  
Keyword(s):  
X Chromosome ◽  
Premature Ovarian Failure ◽  
Ovarian Function ◽  
Sex Chromosome ◽  
Chromosomal Abnormalities ◽  
Population Group ◽  
Ovarian Failure ◽  
Chromosome Mosaicism ◽  
Low Level

The importance of X chromosome in the aetiology of premature ovarian failure (POF) is well-known but in many cases POF still remains idiopathic. Chromosome aneuploidy increase is a physiological phenomenon related to aging, but the role of low-level sex chromosome mosaicism in ovarian function is still undiscovered. Standard cytogenetic analysis was carried out in a total of 269 patients affected by POF: 27 chromosomal abnormalities were identified, including X chromosome and autosomal structural and numerical abnormalities. In 47 patients with 46,XX karyotype we performed interphase FISH using X alpha-satellite probe in order to identify X chromosome mosaicism rate. Aneuploidy rate in the patient group was significantly higher than the general population group. These findings underline the importance of X chromosome in the aetiology of POF and highlight the potential role of low-level sex chromosome mosaicism in ovarian aging that may lead to a premature onset of menopause.

Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis

2007 ◽  
Vol 84 (3) ◽  
pp. 321-327 ◽  
Author(s):  
Zhan-Fen Qin ◽  
Xiao-Fei Qin ◽  
Lei Yang ◽  
Han-Ting Li ◽  
Xing-Ru Zhao ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Polychlorinated Biphenyls ◽  
Sexual Development ◽  
Secondary Sexual

scholarly journals Meier-Gorlin syndrome: Growth and secondary sexual development of a microcephalic primordial dwarfism disorder

2012 ◽  
Vol 158A (11) ◽  
pp. 2733-2742 ◽  
Author(s):  
Sonja A. de Munnik ◽  
Barto J. Otten ◽  
Jeroen Schoots ◽  
Louise S. Bicknell ◽  
Salim Aftimos ◽  
...  
Keyword(s):  
Sexual Development ◽  
Gorlin Syndrome ◽  
Primordial Dwarfism ◽  
Secondary Sexual

Marsupial Cytogenetics

1989 ◽  
Vol 37 (3) ◽  
pp. 331 ◽  
Author(s):  
DL Hayman
Keyword(s):  
X Chromosome ◽  
Dna Sequences ◽  
Chromosome Numbers ◽  
Chromosome Evolution ◽  
Sex Chromosome ◽  
Repeated Dna ◽  
Chromosome X ◽  
X Chromosomes ◽  
Repeated Dna Sequences ◽  
Chromosome Mosaicism

This review includes a list of the chromosome numbers of marsupials and a summary of the main features of chromosome evolution in this group of mammals. Special topics discussed include sex chromosome mosaicism, the size of the marsupial X chromosome, X chromosomes and nucleolar organisers, complex sex chromosome systems, repeated DNA sequences and aspects of meiosis.

Sign in / Sign up

Export Citation Format

Share Document