scholarly journals A locus for spondylocarpotarsal synostosis syndrome at chromosome 3p14

2004 ◽  
Vol 41 (4) ◽  
pp. 266-269 ◽  
Author(s):  
C Steiner
Keyword(s):  
Chromosome 3P14

scholarly journals Increased Expression of the Tail-Anchored Membrane Protein SLMAP in Adipose Tissue from Type 2Tally HoDiabetic Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaoliang Chen ◽  
Hong Ding
Keyword(s):  
Adipose Tissue ◽  
Membrane Protein ◽  
Glucose Uptake ◽  
Glucose Transporter ◽  
Single Gene ◽  
Abdominal Adipose Tissue ◽  
Glut 4 ◽  
Important Regulator ◽  
Chromosome 3P14

The tail-anchored membrane protein, sarcolemmal membrane associated protein (SLMAP) is encoded to a single gene that maps to the chromosome 3p14 region and has also been reported in certain diabetic populations. Our previous studies with db/db mice shown that a deregulation of SLMAP expression plays an important role in type 2 diabetes. MaleTally Homice were bred to present with either normoglycemia (NG) or hyperglycemia (HG). Abdominal adipose tissue from maleTally Homice of the HG group was found to have a significantly lower expression of the membrane associated glucose transporter-4 (GLUT-4) and higher expression of SLMAP compared to tissue from NG mice. There were 3 isoforms expressed in the abdominal adipose tissue, but only 45?kDa isoform of SLMAP was associated with the GLUT-4 revealed by immunoprecipitation data. Knock down studies using SLMAP siRNA with adipocytes resulted in a significant reduction in SLMAP and a decrease in glucose uptake. Thus, SLMAP may be an important regulator of glucose uptake or involved in GLUT-4 fusion/translocation into the plasma membrane of mouse abdominal adipose tissue and changes in SLMAP expression are linked to hyperglycemia and diabetes.

Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14. 1-p12.3

1994 ◽  
Vol 3 (4) ◽  
pp. 553-557 ◽  
Author(s):  
Masayoshl Tachibana ◽  
Luis A. Perez-Jurado ◽  
Atsuo Nakayama ◽  
Colin A. Hodgkinson ◽  
Xu Li ◽  
...  
Keyword(s):  
Human Homolog ◽  
Chromosome 3P14

Molecular Cloning of the Human Proto-oncogene Wnt-5A and Mapping of the Gene (WNT5A) to Chromosome 3p14-p21

Genomics ◽  
1993 ◽  
Vol 18 (2) ◽  
pp. 249-260 ◽  
Author(s):  
Charles C. Clark ◽  
Isabelle Cohen ◽  
Inge Eichstetter ◽  
Linda A. Cannizzaro ◽  
John D. McPherson ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Chromosome 3P14

scholarly journals Chromosome 3p14 Homozygous Deletions and Sequence Analysis of FRA3B

1997 ◽  
Vol 6 (2) ◽  
pp. 193-203 ◽  
Author(s):  
F. Boldog ◽  
R. M. Gemmill ◽  
J. West ◽  
M. Robinson ◽  
L. Robinson ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Homozygous Deletions ◽  
Chromosome 3P14
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