scholarly journals Dermatoglyphic findings in 54 triple-X females and a review of some general principles applying to the soles in sex chromosome aneuploidy.

1975 ◽  
Vol 12 (2) ◽  
pp. 185-192 ◽  
Author(s):  
P Saldana-Garcia
Keyword(s):  
Sex Chromosome ◽  
Sex Chromosome Aneuploidy ◽  
Chromosome Aneuploidy

scholarly journals DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy

2020 ◽  
Author(s):  
Yucheng Wang ◽  
Eilis Hannon ◽  
Olivia A Grant ◽  
Tyler J Gorrie-Stone ◽  
Meena Kumari ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Sex Chromosome ◽  
Klinefelter Syndrome ◽  
Association Studies ◽  
Gene Expression Omnibus ◽  
Sex Chromosome Aneuploidy ◽  
Chromosome Aneuploidy ◽  
Wide Range ◽  
Almost All ◽  
Methylation Patterns

AbstractSex is an important covariate of epigenome-wide association studies due to its strong influence on DNA methylation patterns across numerous genomic positions. Nevertheless, many samples on the Gene Expression Omnibus (GEO) frequently lack a sex annotation or are incorrectly labelled. Considering the influence that sex imposes on DNA methylation patterns, it is necessary to ensure that methods for filtering poor samples and checking of sex assignment are accurate and widely applicable. In this paper, we presented a novel method to predict sex using only DNA methylation density signals, which can be readily applied to almost all DNA methylation datasets of different formats (raw IDATs or text files with only density signals) uploaded to GEO. We identified 4345 significantly (p < 0.01) sex-associated CpG sites present on both 450K and EPIC arrays, and constructed a sex classifier based on the two first components of PCAs from the two sex chromosomes. The proposed method is constructed using whole blood samples and exhibits good performance across a wide range of tissues. We further demonstrated that our method can be used to identify samples with sex chromosome aneuploidy, this function is validated by five Turner syndrome cases and one Klinefelter syndrome case. The proposed method has been integrated into the wateRmelon Bioconductor package.

Sex Chromosome Aneuploidy Alters the Relationship Between Cortical Anatomy and Cognitive Functioning

2020 ◽  
Vol 87 (9) ◽  
pp. S336
Author(s):  
Allysa Warling ◽  
Kathleen Wilson ◽  
Ethan Whitman ◽  
Siyuan Liu ◽  
Liv S. Clasen ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Sex Chromosome ◽  
Sex Chromosome Aneuploidy ◽  
Chromosome Aneuploidy ◽  
The Relationship

Screening, prenatal diagnosis, and prenatal decision for sex chromosome aneuploidy

2019 ◽  
Vol 19 (6) ◽  
pp. 537-542 ◽  
Author(s):  
Yong Xu ◽  
Liyuan Chen ◽  
Yang Liu ◽  
Ying Hao ◽  
Zhiyong Xu ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Sex Chromosome ◽  
Sex Chromosome Aneuploidy ◽  
Chromosome Aneuploidy

Diagnostic Testing Uptake After High-Risk cffDNA Results for Sex Chromosome Aneuploidy [11B]

2017 ◽  
Vol 129 ◽  
pp. 22S
Author(s):  
Anju Suhag ◽  
Patricia Robbins-Furman ◽  
Manju Monga ◽  
Lisa Hollier ◽  
Susan Ramin ◽  
...  
Keyword(s):  
High Risk ◽  
Sex Chromosome ◽  
Diagnostic Testing ◽  
Sex Chromosome Aneuploidy ◽  
Chromosome Aneuploidy ◽  
Testing Uptake
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