scholarly journals Reliability of data from proxy respondents in an international case-control study of cardiovascular disease and oral contraceptives. World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.

1996 ◽  
Vol 50 (6) ◽  
pp. 674-680 ◽  
Author(s):  
N R Poulter ◽  
C L Chang ◽  
T M Farley ◽  
M G Marmot
Author(s):  
Martina Astari Martina Astari

ABSTRACT According to the World Health Organization (WHO 2010) approximately 99% of cases of maternal deaths occur during labor and postpartum. One of the causes of maternal death due to preeclampsia. Country - developing countries maternal mortality rate of 450 / 100,000 live births, this is a very high number. In the hospital Palembang obtained Muhammaddiyah severe preeclampsia incidence by 2013 as many as 85 cases. Many things that cause severe preeclampsia include maternal age, parity, educational level, employment. The purpose of this study was to determine the relationship of maternal age, parity, educational level, work simultaneously with perinatal death. This type of research is a case control study conducted retrospectively. The population in this study were all women giving birth in hospital Muhammadiyah Palembang in the year 2013 that berjumlah2565. The study sample totaled 225 respondents. In this study conducted univariate, bivariate and multivariate analyzes. From the analysis we found no association with maternal age incidence of severe preeclampsia (P Value 0.043 OR 1.799), no parity relationship with the incidence of severe preeclampsia (P Value 0.010 OR 0.617), no correlation with the incidence rate of severe preeclampsia education (P Value 0.027 OR 1.394) , there is a relationship how to work with the incidence of severe preeclampsia (P Value 0.024 OR 0.576), the most dominant variable is the age of the mother. It is suggested to the leadership of Muhammadiyah hospital Palembang is hoped to be able to further improve health care programs for women giving birth so as to prevent the occurrence of complications during labor and to increase outreach programs about the importance of prenatal care and provide knowledge about the complications - complications during childbirth to facilitate the birth process. References       : 16 (2002-2013)     ABSTRAK Menurut World Health Organization (WHO 2010) sekitar 99 % kasus kematian ibu terjadi pada masa persalinan dan pasca persalinan. Salah satu penyebab kematian ibu karena preeklamsia. Dinegara – negara berkembang angka kematian ibu sebesar 450/100.000 kelahiran hidup, ini merupakan angka yang sangat tinggi. Di Rumah Sakit Muhammaddiyah Palembang didapatkan kejadian preeklamsia berat pada tahun 2013 sebanyak 85 kasus. Banyak hal yang menyebabkan preeklamsia berat diantaranya umur ibu, paritas, tingkat pendidikan, pekerjaan. Tujuan penelitian ini untuk mengetahui hubungan umur ibu, paritas, tingkat pendidikan, pekerjaan secara simultan dengan kematian perinatal. Jenis penelitian ini merupakan penelitian case control study yang dilakukan secara retrospektif. Populasi dalam penelitian ini adalah semua ibu bersalin di rumah sakit Muhammadiyah Palembang pada Tahun 2013 yang berjumlah2565. Sampel penelitian ini berjumlah 225 responden. Dalam penelitian ini dilakukan analisis univariat, bivariat dan multivariat. Dari hasil analisis didapatkan ada hubungan umur ibu dengan kejadian preeklamsia berat (P Value 0,043 OR 1,799), ada hubungan paritas dengan kejadian preeklamsia berat (P Value 0,010 OR 0,617), ada hubungan tingkat pendidikan dengan kejadian preeklamsia berat (P Value 0,027 OR 1,394), ada hubungan cara pekerjaan dengan kejadian preeklamsia berat (P Value 0,024 OR 0,576), Variabel paling dominan adalah umur ibu. Disarankan kepada pimpinan rumah sakit Muhammadiyah Palembang Diharapkan untuk dapat lebih meningkatkan program pelayanan kesehatan kepada ibu bersalin sehingga  mencegah terjadinya komplikasi selama persalinan serta meningkatkan program penyuluhan tentang pentingnya pemeriksaan kehamilan  dan memberikan pengetahuan mengenai komplikasi – komplikasi selama masa persalinan untuk memperlancar proses persalinan.


2022 ◽  
pp. 1487-1497
Author(s):  
Wa Ode Nurfalah ◽  
Nur Ulmy Mahmud ◽  
Sumiaty ◽  
Mansur Sididi ◽  
Nurul Hikmah

COVID-19 adalah penyakit menular yang baru ditemukan pada Desember 2019 di Wuhan yang disebabkan oleh SARS-CoV-2. Mulai januari 2020, virus ini menyebar ke luar Tiongkok, pertama di Thailand, Korea Selatan, dan Jepang. Sehingga pada tanggal 11 Maret 2020 World Health Organization (WHO) menyatakan COVID-19 sebagai pandemi. COVID-19 pertama dilaporkan di Indonesia pada tanggal 2 Maret 2020 sejumlah 2 kasus. Virus ini dapat menyerang siapa saja, baik balita, anak-anak, orang dewasa, orang tua, ibu hamil maupun ibu yang sedang menyusui. Namun, beberapa orang memiliki risiko lebih tinggi untuk terinfeksi COVID-19. Tujuan dari penelitian ini untuk mengetahui faktor risiko kejadian COVID-19 pada pasien COVID-19 di Rumah Sakit Umum Daerah (RSUD) Sayang Rakyat Kota Makassar. Jenis penelitian ini adalah observasional analitik dengan rancangan Case Control study. Hasil penelitian ini menunjukan bahwa umur merupakan faktor risiko yang tidak bermakna terhadap kejadian COVID-19 dengan nilai OR=6,556 95% CI 0,764-56,219. Kebiasaan merokok merupakan faktor risiko yang bermakna terhadap kejadian COVID-19 dengan nilai OR=1,447 95% CI 1,447-15,046. Kontak erat merupakan faktor risiko yang bermakna terhadap kejadian COVID-19 dengan nilai OR=188,500 95% CI 38,284-928,114. Komorbid merupakan faktor risiko yang bermakna terhadap kejadian COVID-19 dengan nilai OR=3,406 95% CI 1,486-7,809.  Sebagai saran dalam penelitian ini masyarakat diharapkan untuk mengkonsumsi makanan yang dapat meningkatkan imun tubuh, mengurangi atau bahkan berhenti merokok, selalu mematuhi protokol kesehaatan serta bagi masyarakat yang memiliki komorbid diharapkan dapat mengendalikan komorbidnya.


2007 ◽  
Vol 85 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Lisheng Liu

Statistics from the National Population Census of China revealed a significant increase in the Chinese population, from 590 million in 1953 to 1.26 billion in 2000. The average life expectancy increased to 71.4 years in 2000 compared with the expectancy of 68.6 years a decade before. World Health Organization statistics on the death rate for total cardiovascular disease, coronary heart disease, and stroke in men and women aged 35–74 years revealed discrepancies between rural and urban parts of China. The China Multicenter Collaborative Study of Cardiovascular Epidemiology indicated that cardiovascular disease was the major cause of death for both men and women, with stroke accounting for over 40% of deaths. Ischemia was shown to be the most common subtype of stroke in both sexes. Smoking was an independent risk factor for cardiovascular disease. The World Health Organization reported that the death rate attributable to tobacco was 6.0% worldwide and 9.2% in China in 1990. The latter is projected to reach 16.6% by 2020. In China, the prevalence of hypertension and diabetes mellitus, the two key risk factors of cardiovascular disease, have also increased significantly in the past 20 years. In addition, elevated blood pressure and plasma cholesterol were two important determinants of increased cardiovascular disease in eastern Asia. These studies indicate that an integrated management of comprehensive risk is urgently required to address China’s increasing cardiovascular disease burden.


Healthline ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 28-32
Author(s):  
Kuntalkumar H Patel ◽  
Shreyashkumar Gandhi ◽  
Dhruti Vaidya

Introduction: Globally 17.9 million people die each year from CVDs (Cardio Vascular Diseases) and 85% of all CVD deaths are due to heart attacks and strokes. According to the World Health Organization (WHO), 15 million people worldwide suffer from stroke every year and after ischemic heart disease, stroke is the second most leading cause of death. Objective: To study alcohol consumption as a risk factor in patients with acute strokes. Method: Case control study was conducted among 148 newly diagnosed cases of CT scan / MRI-confirmed stroke and 148 non-stroke controls attending the tertiary hospital of central Gujarat. Sample size calculation was done, assuming the power ratio of the number of controls same as numbers of cases i.e.,1:1, specifying values for two-sided confidence level=95% (error=5%), power of study=80%, odd ratio=2.15, percent of cases with exposure=82% and percent of controls with exposure=68%. Patients who are willing to participate in the study were included. The data were analyzed using the EPI INFO TM 7.0.8.0 software. Results: Out of the total 148 cases, 100 (67.56 per cent) were male and 48 (32.43 per cent) were female. The odds of getting stroke among alcoholic was two times more as compared to non-alcoholic patients. Heavy alcohol drinkers have a significant association. Conclusion: According to the study results male married patients who drank heavily had a higher risk of stroke than light/moderate alcoholics.


2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 144.1-144
Author(s):  
R. Mazzucchelli ◽  
S. Rodriguez-Martin ◽  
A. García-Vadillo ◽  
M. Gil ◽  
A. Rodríguez-Miguel ◽  
...  

Background:There is some evidence from epidemiological studies suggesting that CS and glucosamine could play a role in cardiovascular disease (CVD) prevention (1-4).Studies to date have included prevalent users, therefore a bias that overestimates protection cannot be excluded.Objectives:To test the hypothesis that chondroitin sulphate (CS) or glucosamine reduce the risk of acute myocardial infarction (AMI).Methods:Case-control study nested in a primary cohort composed of patients aged 40 to 99 years, with at least one year of follow-up in the BIFAP database during the 2002-2015 study period. From this cohort of patients, we identified incident cases of AMI and randomly selected five controls per case, matched by exact age, gender, and index date. Adjusted odds ratios (AOR) and their corresponding 95% confidence interval (CI)) were calculated through a conditional logistic regression. Only new users of CS or glucosamine were considered.Results:A total of 23,585 incident cases of AMI and 117,405 controls were included. The mean age was 67.0 (SD 13.4) years and 71.75% were male, in both groups. 558 (2.37%) cases and 3,082 (2.62%) controls used or had used CS. The current use of CS was associated with a lower risk of AMI (AOR 0.57; 95%CI: 0.46–0.72) and disappeared after discontinuation (recent and past users). The reduced risk among current users was observed in both short-term (<365 days AOR 0.58; 95%CI: 0.45-0.75) and long-term users (>364 days AOR 0.56; 95%CI 0.36-0.87), in both sexes (men, AOR=0.52; 95%CI:0.38-0.70; women, AOR=0.65; 95%CI: 0.46-0.91), in individuals over or under 70 years of age (AOR=0.54; 95%CI:0.38-0.77, and AOR=0.61; 95%CI:0.45-0.82, respectively) and in individuals at intermediate (AOR=0.65; 95%CI:0.48-0.91) and high cardiovascular risk (AOR=0.48;95%CI:0.27-0.83), but not in those at low risk (AOR=1.11; 95%CI:0.48-2.56). In contrast, the current use of glucosamine was not associated with either increased or decreased risk of AMI (AOR= 0.86; CI95% 0.66-1.08)Conclusion:Our results support a cardioprotective effect of CS, while no effect was observed with glucosamine. The highest protection was found among subgroups at higher cardiovascular risk.References:[1]Ma H, Li X, Sun D, Zhou T, Ley SH, Gustat J, et al. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. BMJ. 2019;365(Journal Article):l1628.[2]de Abajo FJ, Gil MJ, Garcia Poza P, Bryant V, Oliva B, Timoner J, et al. Risk of nonfatal acute myocardial infarction associated with non-steroidal antiinflammatory drugs, non-narcotic analgesics and other drugs used in osteoarthritis: a nested case-control study. PharmacoepidemiolDrug Saf. 2014;23(11):1128–38.[3]Li Z-H, Gao X, Chung VC, Zhong W-F, Fu Q, Lv Y-B, et al. Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020 Apr 6;annrheumdis-2020-217176.[4]King DE, Xiang J. Glucosamine/Chondroitin and Mortality in a US NHANES Cohort. J Am Board Fam Med. 2020 Dec;33(6):842–7.Disclosure of Interests:Ramón Mazzucchelli Speakers bureau: UCB, Lilly, Grant/research support from: Pfizer, Roche, Amgen, Sara Rodriguez-Martin: None declared, Alberto García-Vadillo: None declared, Miguel Gil: None declared, Antonio Rodríguez-Miguel: None declared, Diana Barreira-Hernández: None declared, Alberto García-Lledó: None declared, Francisco de Abajo: None declared


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