scholarly journals Adverse socioeconomic position across the lifecourse increases coronary heart disease risk cumulatively: findings from the British women's heart and health study

2005 ◽  
Vol 59 (9) ◽  
pp. 785-793 ◽  
Author(s):  
D. A Lawlor
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Socioeconomic Position ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Health Study ◽  
Heart Disease Risk

scholarly journals A systematic comprehensive longitudinal evaluation of dietary factors associated with acute myocardial infarction and fatal coronary heart disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Soodabeh Milanlouei ◽  
Giulia Menichetti ◽  
Yanping Li ◽  
Joseph Loscalzo ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Association Study ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Health Study ◽  
Fatal Coronary Heart Disease ◽  
Heart Disease Risk

AbstractEnvironmental factors, and in particular diet, are known to play a key role in the development of Coronary Heart Disease. Many of these factors were unveiled by detailed nutritional epidemiology studies, focusing on the role of a single nutrient or food at a time. Here, we apply an Environment-Wide Association Study approach to Nurses’ Health Study data to explore comprehensively and agnostically the association of 257 nutrients and 117 foods with coronary heart disease risk (acute myocardial infarction and fatal coronary heart disease). After accounting for multiple testing, we identify 16 food items and 37 nutrients that show statistically significant association – while adjusting for potential confounding and control variables such as physical activity, smoking, calorie intake, and medication use – among which 38 associations were validated in Nurses’ Health Study II. Our implementation of Environment-Wide Association Study successfully reproduces prior knowledge of diet-coronary heart disease associations in the epidemiological literature, and helps us detect new associations that were only marginally studied, opening potential avenues for further extensive experimental validation. We also show that Environment-Wide Association Study allows us to identify a bipartite food-nutrient network, highlighting which foods drive the associations of specific nutrients with coronary heart disease risk.

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