scholarly journals Sex differences in body fat distribution and carotid intima media thickness: cross sectional survey using data from the British regional heart study

2004 ◽  
Vol 58 (8) ◽  
pp. 700-704 ◽  
Author(s):  
D. A Lawlor
Keyword(s):  
Sex Differences ◽  
Body Fat ◽  
Intima Media Thickness ◽  
Fat Distribution ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Media Thickness ◽  
Heart Study ◽  
Using Data

scholarly journals Genetic associations with carotid intima-media thickness link to atherosclerosis biology with sex-differences in sub-Saharan Africans

2021 ◽  
Author(s):  
Palwende Boua ◽  
Jean-Tristan Brandenburg ◽  
Ananyo Choudhury ◽  
Hermann Sorgho ◽  
Engelbert Nonterah ◽  
...  
Keyword(s):  
Sex Differences ◽  
Snp Array ◽  
Clinical Manifestations ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Genetic Associations ◽  
African Countries ◽  
Media Thickness ◽  
Sub Saharan ◽  
Female Specific

Abstract Atherosclerosis precedes the onset of many clinical manifestations of cardiovascular diseases (CVDs). We used carotid intima-media thickness (cIMT) to investigate genetic susceptibility to atherosclerosis in 7894 unrelated adults (3963 women, 3931 men) aged 40 to 60 years resident in four sub-Saharan African countries. cIMT was measured by ultrasound and genotyping was performed on the H3Africa SNP Array. Two new African-specific genome-wide significant loci, SIRPA (p=4.7E-08), and FBXL17 (p=2.5E-08), were identified in the combined dataset. Sex-stratified analysis revealed associations with two male-specific loci, SNX29 (p=6.3E-09) and MAP3K7 (p=5.3E-08), and two female-specific loci, LARP6 (p=2.4E-09) and PROK1 (p=1.0E-08). Regional associations were replicated with known risk loci for atherosclerosis and CVDs with different lead SNPs than in Europeans and significant enrichment for oestrogen response genes for female-specific signals were identified. The genes identified showed biological relevance to atherosclerosis and/or CVDs, as well as sex-differences and transferability of signals from non-African studies.

scholarly journals Advanced Glycation End Products Levels and Carotid Intima Media Thickness in Patients With Rheumatoid Arthritis

2019 ◽  
Vol 10 (2) ◽  
pp. 58
Author(s):  
Ines KNANI ◽  
Hassan BOUZIDI ◽  
Albert LECUBE ◽  
Jawhar GHARBI ◽  
Mohsen KERKENI
Keyword(s):  
Rheumatoid Arthritis ◽  
Advanced Glycation End Products ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Advanced Glycation ◽  
Cross Sectional ◽  
Media Thickness ◽  
Glycation End Products ◽  
End Products

Introduction: No data regarding the relationship of carotid intima media thickness (IMT) and serum advanced glycation end products (AGEs) levels in patients with rheumatoid arthritis (RA). The aim of this study is to evaluate the association between IMT and serum pentosidine, CML and MGO levels in patients with longstanding RA.Methods: In a cross-sectional study, 80 consecutive RA patients with longstanding disease were included and compared with 30 age and sex-matched healthy controls. IMT was measured using ultrasonography. AGEs such as pentosidine, Ne-carboxymethyllysine (CML) and methylglyoxal (MGO) as an intermediate of glycation, were determined by ELISA.Results: Serum pentosidine, CML and MGO levels were increased in RA patients vs control subjects (P = 0.001; P < 0.001; P < 0.001 respectively). IMT was increased with disease activity of RA (P = 0.004) and was associated with serum pentosidine (r = 0.460, P < 0.001), serum CML (r = 0.549, P < 0.001) and serum MGO (r = 0.658, P < 0.001). Furthermore, in a multiple stepwise regression analysis CML and MGO were independently associated with IMT (b= 0.333, P = 0.007; b = 0.690, P < 0.001, respectively).Conclusion: serum pentosidine, CML and MGO were increased in RA patients and were significantly related to IMT. Serum CML and MGO were independently associated with IMT.

scholarly journals Carotid intima-media thickness and metabolic syndrome in a rural population: Results from the Baependi Heart Study

2020 ◽  
Vol 6 ◽  
pp. 100043
Author(s):  
Glaucylara Reis Geovanini ◽  
Iguaracy Pinheiro de Sousa ◽  
Samantha Kuwada Teixeira ◽  
Miguel José Francisco Neto ◽  
Luz Marina Gómez Gómez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Rural Population ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Heart Study
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