scholarly journals A comparison of peripheral blood and buffy coat smear examination for the prediction of bone marrow relapse of acute lymphoblastic leukaemia in childhood.

1983 ◽  
Vol 36 (2) ◽  
pp. 192-194 ◽  
Author(s):  
I M Franklin
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Buffy Coat ◽  
Smear Examination

scholarly journals Preventive Healthcare and Management for Acute Lymphoblastic Leukaemia in Adults: Case Report and Literature Review

Healthcare ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 531
Author(s):  
Wei-Ping Chen ◽  
Wen-Fang Chiang ◽  
Hung-Ming Chen ◽  
Jenq-Shyong Chan ◽  
Po-Jen Hsiao
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Rare Case ◽  
Early Recognition ◽  
Abdominal Sonography ◽  
Clinical Scenarios ◽  
Consciousness Disturbance

Acute lymphoblastic leukaemia (ALL) is diagnosed by the presence of at least 30% lymphoblasts in the bone marrow or 20% lymphoblasts in peripheral blood. ALL may be aggressive and include the lymph nodes, liver, spleen, central nervous system (CNS), and other organs. Without early recognition and timely treatment, ALL will progress quickly and may have poor prognosis in clinical scenarios. ALL is a rare type of leukaemia in adults but is the most common type in children. Precipitating factors such as environmental radiation or chemical exposure, viral infection, and genetic factors can be associated with ALL. We report a rare case of ALL with symptomatic hypercalcaemia in an adult woman. The patient presented with general weakness, poor appetite, bilateral lower limbs oedema, consciousness disturbance, and lower back pain for 3 weeks. She had a history of cervical cancer and had undergone total hysterectomy, chemotherapy, and radiation therapy. Her serum calcium level was markedly increased, at 14.1 mg/dl at admission. Neck magnetic resonance imaging, abdominal sonography, abdominal computed tomography, and bone marrow examination were performed. Laboratory data, including intact parathyroid hormone (i-PTH), peripheral blood smear, and 25-(OH) D3, were checked. Bone marrow biopsy showed B cell lymphoblastic leukaemia. Chemotherapy was initiated to be administered but was discontinued due to severe sepsis. Finally, the patient died due to septic shock. This was a rare case of B cell ALL in an adult complicated by hypercalcaemic crisis, which could be a life-threatening emergency in clinical practice. Physicians should pay attention to the associated risk factors. Early recognition and appropriate treatment may improve clinical outcomes.

scholarly journals [Cytological features of acute leukaemia in the central region of Tunisia]

2004 ◽  
Vol 10 (4-5) ◽  
pp. 640-647
Author(s):  
N. Braham Jmili ◽  
A. Ben Abdel Aziz ◽  
M. Nagara ◽  
T. Mahjoub ◽  
H. Ghannem ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Central Region ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Acute Leukaemia ◽  
Acute Myeloblastic Leukemia ◽  
Registry Data ◽  
Cytological Features ◽  
Age Range

In Tunisia, because of an absence of population registry, data on acute leukaemia are scarce. We studied the epidemiological and cytological characteristic of 193 patients with acute leukaemia. Haemograms were carried out and slides for peripheral blood and bone marrow were prepared for each patient. The age range of the patients was 10 months to 83 years with a predominance of males [ratio:1.27]. As regards type of leukaemia, 40.4% had acute lymphoblastic leukaemia, 51.8% had acute myeloblastic leukemia and 7.8% were unclassified. Diagnosis was made at less than 10 years in 31.6% of cases and 72% of these were the lymphoblastic type. Anaemia [Hb < 11 g/dL was found in 85% of cases, thrombocytopenia [platelets < 100 000/mm3] in 80.5% and hyperleukocytosis [WBC > 100 000/mm3] in 14.5% of cases with blasts in peripheral blood in 92% of cases

scholarly journals Outcome of Childhood Acute Lymphoblastic Leukaemia after Induction Therapy --- Three-Year Experience in a Tertiary Care Hospital in Bangladesh

2017 ◽  
Vol 7 (1) ◽  
pp. 25-28
Author(s):  
M Belayet Hossain ◽  
M Selimuzzaman ◽  
Nilufar Akter Banu Choudhury ◽  
Abdul Wahab
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Induction Therapy ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Induction Phase ◽  
Care Hospital ◽  
Long Term Outcome ◽  
Blast Cells ◽  
Bone Marrow Study

Background: The incidence of different malignancies is increasing among the world populations. Acute lymphoblastic leukaemia (ALL) is the most common of all the paediatric malignancies. Response to induction therapy is one of the most important predictors of long term outcome of ALL.Objective: To see the immediate outcome of paediatric ALL patients following induction therapy.Materials and Methods: This retrospective study was conducted from January 2013 to December 2015. Total 221 paediatric ALL patients were included in this study. Diagnosis was based on history, examination, blast cells count on peripheral blood film and bone marrow study, CSF study and immunophenotyping of peripheral blood/bone marrow aspirate in patients who were financially capable. Among them, parents of 40 (18%) patients did not agree to start chemotherapy. According to Modified UK ALL 2003 protocol (Regimen A & B) 181 patients were given induction therapy (vincristine, prednisolone, L-asparaginase, and daunomycin) in high risk patients. Among them 14 patients discontinued, 10 patients died during chemotherapy and rest 157 patients completed induction phase. Bone marrow study was repeated after completion of induction therapy and remission pattern was seen.Results: Out of 157 chemotherapy completed patients, 137 (87%) went into complete remission (<5% blast cells in bone marrow), 14 (9%) into partial remission (5--25% blast cells in bone marrow) and 6 (4%) was not in remission (>25% blast cells in the bone marrow). Ten (5.5%) patients died due to bleeding, febrile neutropenia and sepsis during the course of induction therapy.Conclusion: ALL in children is curable with effective chemotherapy. Poverty, ignorance and misconception regarding outcome are responsible for refusal and discontinuation of chemotherapy in third world countries like Bangladesh. Mortality and treatment cost can be reduced with the improvement of the facilities for isolation, barrier nursing and supportive treatment, and by creating awareness.J Enam Med Col 2017; 7(1): 25-28

scholarly journals Evaluation of qPCR on blood and skin microbiopsies, peripheral blood buffy coat smear, and urine antigen ELISA for diagnosis and test of cure for visceral leishmaniasis in HIV-coinfected patients in India: a prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042519
Author(s):  
Sophie I Owen ◽  
Sakib Burza ◽  
Shiril Kumar ◽  
Neena Verma ◽  
Raman Mahajan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Hiv Infection ◽  
Peripheral Blood ◽  
Medical Science ◽  
Bone Marrow Aspiration ◽  
Buffy Coat ◽  
Tropical Medicine ◽  
Urine Antigen ◽  
Antigen Elisa

IntroductionHIV coinfection presents a challenge for diagnosis of visceral leishmaniasis (VL). Invasive splenic or bone marrow aspiration with microscopic visualisation of Leishmania parasites remains the gold standard for diagnosis of VL in HIV-coinfected patients. Furthermore, a test of cure by splenic or bone marrow aspiration is required as patients with VL-HIV infection are at a high risk of treatment failure. However, there remain financial, implementation and safety costs to these invasive techniques which severely limit their use under field conditions.Methods and analysisWe aim to evaluate blood and skin qPCR, peripheral blood buffy coat smear microscopy and urine antigen ELISA as non-invasive or minimally invasive alternatives for diagnosis and post-treatment test of cure for VL in HIV-coinfected patients in India, using a sample of 91 patients with parasitologically confirmed symptomatic VL-HIV infection.Ethics and disseminationEthical approval for this study has been granted by The Liverpool School of Tropical Medicine, The Institute of Tropical Medicine in Antwerp, the University of Antwerp and the Rajendra Memorial Research Institute of Medical Science in Patna. Any future publications will be published in open access journals.Trial registration numberCTRI/2019/03/017908.

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