scholarly journals Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage.

1977 ◽  
Vol 30 (2) ◽  
pp. 141-143 ◽  
Author(s):  
S P Wilkinson ◽  
H Moodie ◽  
V A Arroyo ◽  
R Williams
Keyword(s):  
Renal Impairment ◽  
Liver Damage ◽  
Paracetamol Overdose ◽  
Acute Liver Damage

Analysis of Factors Responsible for Continuing Mortality after Paracetamol Overdose

1986 ◽  
Vol 5 (3) ◽  
pp. 201-206 ◽  
Author(s):  
R. B. Read ◽  
J. M. Tredger ◽  
R. Williams
Keyword(s):  
Liver Failure ◽  
Liver Damage ◽  
Paracetamol Overdose ◽  
Severe Liver ◽  
College Hospital ◽  
King's College ◽  
Accident And Emergency ◽  
Drinking History ◽  
Severe Liver Damage ◽  
Complete Series

1 To determine reasons for the continuing mortality in patients taking a paracetamol overdose, the presentation, drug ingestion history, patient background, use of antidote ( N-acetylcysteine and methionine), clinical course and outcome were determined in 247 patients treated at King's College Hospital in 1982 and 1983. Patients (147) were referred from other centres because of severe liver damage and 100 were local patients seen in the accident and emergency department. 2 Survival in the local patients was 100% and, for those with severe liver damage, 49 and 63% (1982 and 1983 values). Delay in initial presentation to hospital was a major factor in determination of an adverse outcome, with a median delay of 30 h in the referred patients and 8 h in the local cases. Such a delay precluded administration of antidote to the majority of patients in the referred group, but in 11 cases where antidote could have been given a full course was not provided and all 11 patients died. Included among these were four patients in whom the serum paracetamol concentration was in the ‘non-toxic’ range. 3 One patient with a chronic alcohol-drinking history (> 200 g/day) received N-acetylcysteine at 12 h but died from liver failure. However, in the complete series prior alcohol consumption was not associated with a significantly worse prognosis and simultaneous ingestion of alcohol with paracetamol had no effect on outcome. 4 The concomitant ingestion of dextropropoxyphene caused an early and marked impairment of consciousness unrelated to any hepatotoxicity but, in three cases where dextropropoxyphene combinations were used, death occurred subsequently from liver failure.

Effect of preliminary fasting on development of acute liver damage by D-galactosamine in rats

1989 ◽  
Vol 107 (1) ◽  
pp. 38-41
Author(s):  
D. Adzharov ◽  
N. Donchev ◽  
M. Kerimova ◽  
E. Naidenova ◽  
B. Borov ◽  
...  
Keyword(s):  
Liver Damage ◽  
Acute Liver Damage

Paracetamol overdose

1976 ◽  
Vol 14 (2) ◽  
pp. 5-7
Keyword(s):  
At Risk ◽  
Liver Damage ◽  
Fulminant Hepatitis ◽  
Therapeutic Dose ◽  
Renal Damage ◽  
Hepatic Necrosis ◽  
Paracetamol Overdose ◽  
Microsomal Enzymes ◽  
Concomitant Increase ◽  
Main Metabolite

Paracetamol is a main metabolite of phenacetin, and since its introduction it has become increasingly popular as a mild analgesic which is available without prescription. When taken in the recommended therapeutic dose of l g 6-hourly, paracetamol is relatively free from unwanted effects, and in particular, unlike phenacetin, there is little to associate it with renal damage. However, when taken as a single overdose, paracetamol can cause hepatic necrosis, the severity of which seems to be proportional to the dose of drug absorbed. All patients ingesting over 10 g (20 × 500 mg tablets) are at risk from liver damage, which may be potentiated by previous consumption of substances that induce microsomal enzymes, such as barbiturates or alcohol. Since the first reported cases of fulminant hepatitis due to paracetamol overdose in 1966 the number of cases of such self-poisoning has risen annually, with a concomitant increase in the number of deaths.

Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

2008 ◽  
Vol 31 (9) ◽  
pp. 1160-1165 ◽  
Author(s):  
Hee Seung Lee ◽  
Kyung-Hee Jung ◽  
Sang-Won Hong ◽  
In-Suh Park ◽  
Chongmu Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Acute Liver Damage

LIVER DAMAGE AFTER PARACETAMOL OVERDOSE COMPARISON OF LIVER-FUNCTION TESTS, FASTING SERUM BILE ACIDS, AND LIVER HISTOLOGY

The Lancet ◽  
1975 ◽  
Vol 306 (7935) ◽  
pp. 579-581 ◽  
Author(s):  
Oliver James ◽  
S.H. Roberts ◽  
AdrianP. Douglas ◽  
M. Lesna ◽  
L. Pulman ◽  
...  
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Liver Damage ◽  
Liver Function Tests ◽  
Liver Histology ◽  
Paracetamol Overdose ◽  
Fasting Serum ◽  
Serum Bile Acids ◽  
Function Tests

Protective and Therapeutic Effects of Curcuma xanthorrhiza on Hepatotoxin-induced Liver Damage

1995 ◽  
Vol 23 (03n04) ◽  
pp. 243-254 ◽  
Author(s):  
Song-Chow Li ◽  
Chun-Ching Lin ◽  
Yun-Ho Lin ◽  
S. Supriyatna ◽  
Chao-Wei Teng
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Intraperitoneal Administration ◽  
Therapeutic Effects ◽  
Acute Liver Damage ◽  
Liver Injuries ◽  
Acute Elevation ◽  
Serum Transaminases ◽  
Hepatoprotective Agent ◽  
Curcuma Xanthorrhiza

Curcuma xanthorrhiza Roxb. (Zingiberaceae family, commonly known as temu lawak or Javanese turmeric in Indonesia), which is found both wild and cultivated in Indonesia, has been traditionally used for medicinal purposes. C. xanthorrhiza is also used as a tonic in Indonesia. The aim of the present study is to clarify whether C. xanthorrhiza treatment may prevent acute liver damage induced by acetaminophen and carbon tetrachloride in mice. The results clearly indicated that extract of C. xanthorrhiza could reduce significantly the acute elevation of serum transaminases levels induced by the two kinds of hepatotoxins, and alleviated the degree of liver damage at 24 hours after the intraperitoneal administration of two hepatotoxins. It may be concluded that C. xanthorrhiza can protect the liver from various hepatotoxins, hence C. xanthorrhiza could be useful in the treatment of liver injuries and has promise as a kind of broad spectrum hepatoprotective agent.

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