scholarly journals Composite large cell neuroendocrine carcinoma and adenocarcinoma of the common bile duct

2006 ◽  
Vol 59 (1) ◽  
pp. 105-107 ◽  
Author(s):  
K Sato
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
The Common

scholarly journals Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report

2014 ◽  
Vol 20 (47) ◽  
pp. 18048-18052 ◽  
Author(s):  
Sung Bae Park ◽  
Suk Bae Moon ◽  
Young Joon Ryu ◽  
Jeana Hong ◽  
Yang Hee Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
The Common

scholarly journals Large-cell neuroendocrine carcinoma of the common bile duct: a case report and a review of literature

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Makoto Murakami ◽  
Kanji Katayama ◽  
Shigeru Kato ◽  
Daisuke Fujimoto ◽  
Mitsuhiro Morikawa ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Review Of Literature ◽  
The Common

scholarly journals Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
John Wysocki ◽  
Rishi Agarwal ◽  
Laura Bratton ◽  
Jeremy Nguyen ◽  
Mandy Crause Weidenhaft ◽  
...  
Keyword(s):  
Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
Spindle Cell ◽  
Clear Cell ◽  
Extrahepatic Bile Duct ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Duct Carcinoma ◽  
First Case ◽  
The Common

Mixed adenoneuroendocrine carcinomas, spindle cell carcinomas, and clear cell carcinomas are all rare tumors in the biliary tract. We present the first case, to our knowledge, of an extrahepatic bile duct carcinoma composed of all three types. A 65-year-old man with prior cholecystectomy presented with painless jaundice, vomiting, and weight loss. CA19-9 and alpha-fetoprotein (AFP) were elevated. Cholangioscopy revealed a friable mass extending from the middle of the common bile duct to the common hepatic duct. A bile duct excision was performed. Gross examination revealed a 3.6 cm intraluminal polypoid tumor. Microscopically, the tumor had foci of conventional adenocarcinoma (CK7-positive and CA19-9-postive) surrounded by malignant-appearing spindle cells that were positive for cytokeratins and vimentin. Additionally, there were separate areas of large cell neuroendocrine carcinoma (LCNEC). Foci of clear cell carcinoma merged into both the LCNEC and the adenocarcinoma. Tumor invaded through the bile duct wall with extensive perineural and vascular invasion. Circumferential margins were positive. The patient’s poor performance status precluded adjuvant therapy and he died with recurrent and metastatic disease 5 months after surgery. This is consistent with the reported poor survival rates of biliary mixed adenoneuroendocrine carcinomas.

scholarly journals Large Cell Neuroendocrine Carcinoma of the Bile Duct, a Case Report and Review of the Literature

2017 ◽  
Vol 50 (1) ◽  
pp. 33-42
Author(s):  
Noriaki Kyogoku ◽  
Kazuhiro Iwai ◽  
Yasunori Yoshimi ◽  
Hayato Hosoi ◽  
Aya Matsui ◽  
...  
Keyword(s):  
Case Report ◽  
Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Review Of The Literature

Large-cell neuroendocrine carcinoma of the distal bile duct

2009 ◽  
Vol 2 (4) ◽  
pp. 291-295 ◽  
Author(s):  
Toshihiko Kohashi ◽  
Yasuhiro Matsugu ◽  
Hideki Nakahara ◽  
Ichiro Ohmori ◽  
Hiroyuki Egi ◽  
...  
Keyword(s):  
Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Distal Bile Duct

scholarly journals Neuroendocrine carcinoma of the common bile duct associated with congenital bile duct dilatation: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yoshitaka Kiya ◽  
Yuichi Nagakawa ◽  
Chie Takishita ◽  
Hiroaki Osakabe ◽  
Hitoe Nishino ◽  
...  
Keyword(s):  
Bile Duct ◽  
Adjuvant Chemotherapy ◽  
Common Bile Duct ◽  
Large Cell ◽  
Final Diagnosis ◽  
Preoperative Imaging ◽  
Distal Cholangiocarcinoma ◽  
Bile Duct Dilatation ◽  
Duct Dilatation ◽  
The Common

Abstract Background Cholangiocarcinoma is frequently observed in patients with congenital bile duct dilatation (CBDD). Most cholangiocarcinomas are adenocarcinomas. Other types, especially neuroendocrine carcinomas (NECs), are rare. To the best of our knowledge, this is the third reported case of an NEC of the common bile duct associated with CBDD and the first to receive adjuvant chemotherapy for advanced disease. Case presentation A 29-year-old woman presented with upper abdominal pain. Preoperative imaging indicated marked dilatation of the common bile duct and a tumor in the middle portion of the common bile duct. She was suspected of having distal cholangiocarcinoma associated with CBDD and underwent pylorus-preserving pancreaticoduodenectomy. Pathological and immunohistological findings led to a final diagnosis of large-cell NEC (pT3aN1M0 pStageIIB). The postoperative course was uneventful, and she was administered cisplatin and irinotecan every 4 weeks (four cycles) as adjuvant chemotherapy. She has remained recurrence-free for 16 months. Conclusions NEC might be a differential diagnosis in cases of cholangial tumor associated with congenital bile duct dilatation. This presentation is rare and valuable, and to establish better treatment for NEC, further reports are necessary.

scholarly journals A case of neuroendocrine carcinoma of the common bile duct

2003 ◽  
Vol 42 (3) ◽  
pp. 235-238 ◽  
Author(s):  
Hirofumi SAKURAI ◽  
Akiko KAMIGAITO ◽  
Noriko HOSAKA
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Neuroendocrine Carcinoma ◽  
The Common
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