scholarly journals Association of coronary plaque composition and arterial remodelling: a virtual histology analysis by intravascular ultrasound

Heart ◽  
2007 ◽  
Vol 93 (8) ◽  
pp. 928-932 ◽  
Author(s):  
J.-F. Surmely ◽  
K. Nasu ◽  
H. Fujita ◽  
M. Terashima ◽  
T. Matsubara ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Coronary Plaque ◽  
Plaque Composition ◽  
Virtual Histology

Virtual histology intravascular ultrasound and optical coherence tomography in percutaneous coronary intervention

2010 ◽  
pp. 174-182
Author(s):  
Ravinay Bhindi ◽  
Keith M. Channon
Keyword(s):  
Optical Coherence Tomography ◽  
Intravascular Ultrasound ◽  
Coronary Atherosclerosis ◽  
Experimental Studies ◽  
Coronary Plaque ◽  
Optical Coherence ◽  
Plaque Composition ◽  
Virtual Histology ◽  
Luminal Stenosis ◽  
Artery Disease

The inadequacies of angiography to identify and characterize coronary atherosclerosis were not fully appreciated until pathologic studies revealed that coronary atherosclerosis in patients with fatal myocardial infarction was typically diffuse and in many cases was accompanied by positive remodelling, without luminal stenosis. Pathologic studies also identified the critical pathophysiogical role of plaque rupture in coronary thrombosis, and the appreciation that plaque biology and composition, rather than luminal stenosis alone, were more critical determinants of plaque behaviour. Clinical and experimental studies have shown that the vulnerable plaque, prone to rupture, is characterized by a large lipid core rich in inflammatory cells, a thin fibrous cap, and by positive remodelling. The development of novel intracoronary imaging techniques has enabled a greater appreciation of plaque composition in the pathogenesis of coronary artery disease in living patients. In particular, advances in intravascular ultrasound (IVUS) to provide ‘virtual histology’ of coronary plaque components, and optical coherence tomography (OCT) to define plaque composition in exquisite detail have provided new insights into the relationships between coronary plaque, the risk of clinical events, and the response of the vessel wall to percutaneous intervention.

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