scholarly journals Increased carotid intima-media thickness in healthy young subjects with a parental history of hypertension (parental hypertension and vascular health)

Heart ◽  
2007 ◽  
Vol 93 (3) ◽  
pp. 368-369 ◽  
Author(s):  
S. Cuomo ◽  
G. Gaeta ◽  
P. Guarini ◽  
G. Tudisca ◽  
M. De Michele ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vascular Health ◽  
Parental History ◽  
Media Thickness ◽  
History Of ◽  
Young Subjects

scholarly journals A study of lipid profile and carotid artery and abdominal aorta intima-media thickness in children with parental history of premature ischemic heart disease

2018 ◽  
Vol 5 (3) ◽  
pp. 1013 ◽  
Author(s):  
Puneeth K. Pai ◽  
Nagendra K. ◽  
Savitha Mysore Ramaraj
Keyword(s):  
Heart Disease ◽  
Carotid Artery ◽  
Ischemic Heart Disease ◽  
Abdominal Aorta ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Ischemic Heart ◽  
Parental History ◽  
Media Thickness ◽  
History Of

Background: Children born to parents with ischemic heart disease (IHD) can have dyslipidemia, a marker for IHD, detectable in early childhood and track to adulthood. Dyslipidemia along with factors like BMI, diet, sedentary activity increases risk of child developing IHD in adulthood. Early detection with non-invasive methods such as B mode ultrasound to measure carotid artery and abdominal aorta intima-media thickness can help in modification of these risk factors by suitable interventional strategies. The objectives of this study was to study the lipid profile and carotid artery and abdominal aorta intima-media thickness among children in the age group 5-18 years born to parents with history of premature IHD.Methods: 23 children of parents with premature IHD and aged matched 28 controls without any family history of IHD were analyzed for cardiovascular risk factors: lipid profile and carotid and abdominal aorta intima-media thickness. The carotid intima-media thickness and abdominal aorta intima-media thickness was found by using B mode ultrasound.Results: Mean abdominal aorta intima-media thickness was significantly higher among children with parental history of premature IHD than in those without it. Abdominal aorta intima-media thickness also showed significant positive correlation with total cholesterol. Carotid intima-media thickness showed positive correlation with the waist circumference. Mean total cholesterol levels (TC), low density lipoprotein cholesterol (LDL) and triglycerides (TG) were higher in children with family history as compared to children without family history but it was not statistically significant.Conclusions: Abdominal aortic IMT is significantly more among children with parental history of premature ischemic heart disease compared to children without parental history of premature ischemic heart disease. Abdominal aortic intima-media thickness has significant association with total cholesterol while carotid intima-media thickness is significantly associated with waist circumference.

scholarly journals Carotid Intima Media Thickness and Comorbid Cardiometabolic Dysfunction in Women: The SWAN Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 55-55
Author(s):  
Aleda Leis ◽  
Emma Barinas-Mitchell ◽  
Ana Baylin ◽  
Samar El Khoudary ◽  
Elizabeth Jackson ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Obese Women ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Media Thickness ◽  
Prevalence Of Obesity ◽  
History Of ◽  
Sectional Analysis ◽  
Combined Impact

Abstract Metabolic syndrome (MetS) and obesity are risk factors for atherosclerosis but their combined impact is unknown. The aim of this study was to quantify the added risk of obesity on carotid artery intima media thickness (cIMT), an early indicator for atherosclerosis, beyond MetS alone. The Study of Women’s Health Across the Nation (SWAN) is a multi-center, multi-ethnic cohort of women traversing the midlife into early late adulthood. cIMT was assessed between 2005-2007 and MetS, obesity and covariates were measured at the same time. This cross-sectional analysis is restricted to 1,433 women with a body mass index ≥18.5 kg/m2 and free of cardiovascular disease (CVD) when cIMT was measured. Mean maximum cIMT was related to obesity, MetS and their interaction using multivariable linear regression models. The average age was 60 years (standard deviation 2.7) and the prevalence of obesity and MetS were 44% and 35%, respectively. Both conditions occurred in 24% of women. After adjustment for age, race, smoking, family history of heart disease, and antilipemic medications, obese women had a 0.051mm (95% confidence interval (CI): 0.033,0.070; p<0.001) larger maximum cIMT versus women not obese and women with MetS had a 0.066mm (95%CI: 0.042,0.090; p<0.001) larger maximum cIMT versus women without MetS. There was a statistically significant antagonistic interaction between obesity and MetS; women with both had a mean cIMT of 0.972mm (95%CI: 0.955,0.989) and MetS alone a cIMT of 0.961mm (95%CI:0.938,0.983). This suggests that there is only a small risk of obesity on augmenting cIMT beyond MetS alone.

Abstract 2223: Carotid Intima Media Thickness Progression is Modest in Statin-Treated Familial Hypercholesterolemia Patients - Results from a Patient Level Meta-Analysis of 1257 Patients

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Menno Vergeer ◽  
Rong Zhou ◽  
Raphael Duivenvoorden ◽  
Joerg Koglin ◽  
Yale B Mitchel ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
High Dose ◽  
Media Thickness ◽  
Framingham Risk ◽  
History Of ◽  
Change In Mean

In the past, patients with heterozygous familial hypercholesterolemia (HeFH) were believed to be an ideal population to study changes in carotid intima media thickness (cIMT) based on their aggressive lipid disorder and high incidence of atherosclerotic events. However, following publication of recent cIMT trials in this population, the feasibility of demonstrating a reduction of cIMT progression in statin-treated HeFH patients has come under scrutiny. To inform future study designs, we evaluated cIMT progression and baseline predictors of cIMT progression (change in mean cIMT for all segments and common carotid artery (CCA) cIMT over 1 and 2 years), in merged data of 1257 patients from the statin arms of the ASAP, RADIANCE 1, CAPTIVATE and ENHANCE studies and performed backward regression analyses with prespecified co-variates. Based on this analysis, bootstrap analyses were performed to estimate cIMT progression for various hypothetical in- and exclusion criteria. For all studies combined, 2-year mean cIMT progression was 0.0102 ± 0.1348 mm. Positive predictors of this progression were prior use of high dose statins and use of other lipid-modifying therapy. Positive predictors of 1-year mean cIMT progression and 1 & 2 year CCA cIMT progression were age, history of hypertension, Framingham risk score, female gender, high dose statin use and history of CAD; negative predictors were screening LDL-C and ApoA-I. In simulations, HeFH patients previously taking statin and over 50 years of age had an estimated 2-year mean cIMT progression of 0.0216 ± 0.155 mm (based on n = 380). Two year progression for patients with a history of CAD or a Framingham risk score ≥ 10 would be estimated at 0.0197 ± 0.158 mm (based on n = 334). This study shows that cIMT progression in a contemporary HeFH patient population is substantially lower than anticipated, limiting the usefulness of cIMT studies to test new therapies in this population. While focus on individual subgroups characterized by population-specific predictors of cIMT progression results in slightly higher cIMT progression, the current analysis suggests that other patient populations should be considered for future cIMT studies.

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