scholarly journals Carcinoid heart disease: presentation, diagnosis, and management

Heart ◽  
2004 ◽  
Vol 90 (10) ◽  
pp. 1224-1228 ◽  
Author(s):  
D. J Fox
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease ◽  
Diagnosis And Management

scholarly journals Biomarkers in Small Intestine NETs and Carcinoid Heart Disease: A Comprehensive Review

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 950
Author(s):  
Markos Kalligeros ◽  
Leonidas Diamantopoulos ◽  
Christos Toumpanakis
Keyword(s):  
Small Intestine ◽  
Heart Disease ◽  
Chromogranin A ◽  
Clinical Utility ◽  
Disease Status ◽  
Carcinoid Heart Disease ◽  
Mrna Transcript ◽  
Comprehensive Review ◽  
Diagnosis And Management ◽  
Novel Biomarkers

Biomarkers remain a valuable tool for the diagnosis and management of Neuroendocrine tumors (NETs). Traditional monoanalyte biomarkers such as Chromogranin A (CgA) and 5-Hydrocyondoleacetic acid (5-HIAA) have been widely used for many years as diagnostic, predictive and prognostic biomarkers in the field of NETs. However, the clinical utility of these molecules often has limitations, mainly inherent to the heterogeneity of NETs and the fact that these tumors can often be non-secretory. The development of new molecular multianalyte biomarkers, especially the mRNA transcript based “NETest”, has rapidly evolve the field and gives the ability for a “liquid biopsy” which can reliably assess disease status in real time. In this review we discuss the use of established and novel biomarkers in the diagnosis and management of small intestine NETs and carcinoid heart disease.

The proinflammatory molecule, VAP-1, is enriched in the stroma of midgut NETs and plaques of carcinoid heart disease valves

2018 ◽  
Author(s):  
Vandana M Sagar ◽  
Desley AH Neil ◽  
Pantelitsa Papakyriacou ◽  
Tahir Shah ◽  
Boyang Liu ◽  
...  
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease ◽  
Proinflammatory Molecule

scholarly journals Carcinoid Heart Disease

1974 ◽  
Vol 67 (5) ◽  
pp. 321-322
Author(s):  
S H Dave ◽  
E C B Keat
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

Carcinoid Heart Disease: a Review

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Faidon-Marios Laskaratos ◽  
Joseph Davar ◽  
Christos Toumpanakis
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

scholarly journals Flow-driven right-to-left cardiac shunting in a patient with carcinoid heart disease and patent foramen ovale without elevated right atrial pressure: a case report and literature review

2020 ◽  
Author(s):  
Parinita Dherange ◽  
Nelson Telles ◽  
Kalgi Modi
Keyword(s):  
Heart Disease ◽  
Patent Foramen Ovale ◽  
Atrial Septum ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Right Atrial Pressure ◽  
Heart Catheterization ◽  
Carcinoid Heart Disease ◽  
Foramen Ovale ◽  
Arterial Blood

Abstract Background Carcinoid heart disease is present in approximately 20% of the patients with carcinoid syndrome and is associated with poor prognosis. It usually manifests with right-sided valvular involvement including tricuspid insufficiency and pulmonary stenosis. Patent foramen ovale (PFO) is present in approximately 50% of the patients with carcinoid heart disease which is twice higher than the general population. Right-to-left shunting through a PFO can occur either due to higher right atrial pressure than left (pressure-driven) or when the venous flow is directed towards the PFO (flow-driven) in the setting of normal intracardiac pressures. We report a rare case of flow-driven right-to-left atrial shunting via PFO in a patient with carcinoid heart disease. Case summary A 54-year-old male with a metastatic neuroendocrine tumour to liver presented with progressive shortness of breath for 5 months. Patient was found to be hypoxic with oxygen saturation of 78% and examination revealed a holosystolic murmur. Arterial blood gas showed oxygen tension of 43 mmHg. A transthoracic and transoesophageal echocardiogram showed aneurysmal inter-atrial septum with a PFO, severe tricuspid regurgitation directed anteriorly towards the inter-atrial septum leading to a marked right-to-left shunt. Right heart catheterization showed right atrial pressure of 8 mmHg, mean pulmonary artery pressure of 12 mmHg, and normal oxygen saturations in the right atrium, right ventricle, and pulmonary arteries. The patient then underwent closure of the PFO along with tricuspid valve and pulmonary valve replacement at an experienced cardiovascular surgical centre and has been asymptomatic since. Conclusion Right-to-left shunting through a PFO in patients with normal right atrial pressure can be successfully treated with closure of the PFO. Thus, understanding the mechanism of intracardiac shunts is important to accurately diagnose and treat this rare and fatal condition.

scholarly journals Carcinoid heart disease

2014 ◽  
Vol 33 (1) ◽  
pp. 59-60
Author(s):  
Ingrid do Rosário ◽  
Maria João Andrade ◽  
Isabel Arroja ◽  
Ana Plácido ◽  
Miguel Mendes
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease

scholarly journals Echocardiographic spectrum of carcinoid heart disease

1991 ◽  
Vol 17 (2) ◽  
pp. A49
Author(s):  
Patricia A. Pellikka ◽  
Bijoy K. Khandheria ◽  
John A. Callahan ◽  
James B. Seward ◽  
A.Jamil Tajik
Keyword(s):  
Heart Disease ◽  
Carcinoid Heart Disease
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