scholarly journals Enhanced endothelin-1 degradation by intravenous morphine in patients with congestive heart failure: role of neutral endopeptidase 24.11

Heart ◽  
2003 ◽  
Vol 89 (2) ◽  
pp. 211-212 ◽  
Author(s):  
T-L Wang
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Neutral Endopeptidase ◽  
Endothelin 1 ◽  
Endopeptidase 24.11 ◽  
Intravenous Morphine

scholarly journals Role of neutral endopeptidase 24.11 in AV fistular rat model of heart failure

1996 ◽  
Vol 31 (6) ◽  
pp. 891-898 ◽  
Author(s):  
M. Wegner ◽  
C. Hirth-Dietrich ◽  
J.-P. Stasch
Keyword(s):  
Heart Failure ◽  
Rat Model ◽  
Neutral Endopeptidase ◽  
Endopeptidase 24.11

scholarly journals Enhanced endothelin-1-induced contractions in mesenteric arteries from rats with congestive heart failure: role of ETBreceptors

2001 ◽  
Vol 3 (3) ◽  
pp. 293-299 ◽  
Author(s):  
Anders Bergdahl ◽  
Stig Valdemarsson ◽  
Mikael Adner ◽  
Xiang-Ying Sun ◽  
Tomas Hedner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Mesenteric Arteries ◽  
Endothelin 1

The Role of Neutral Endopeptidase in Dogs With Evolving Congestive Heart Failure

Circulation ◽  
1995 ◽  
Vol 91 (7) ◽  
pp. 2036-2042 ◽  
Author(s):  
Kenneth B. Margulies ◽  
Paul L. Barclay ◽  
John C. Burnett
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Neutral Endopeptidase

Biologic role of atrial natriuretic factor clearance receptor in congestive heart failure

1993 ◽  
Vol 265 (1) ◽  
pp. H401-H408 ◽  
Author(s):  
M. A. Perrella ◽  
L. L. Aarhus ◽  
D. M. Heublein ◽  
J. A. Lewicki ◽  
J. C. Burnett
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Atrial Natriuretic Factor ◽  
Neutral Endopeptidase ◽  
Amino Acid Peptide ◽  
Natriuretic Factor ◽  
Anesthetized Dogs ◽  
Clearance Receptor ◽  
Atrial Natriuretic

Atrial natriuretic factor (ANF) is a circulating 28-amino acid peptide that functions in the regulation of sodium homeostasis and vascular tone. ANF metabolism occurs via degradation by neutral endopeptidase 24.11 and binding to the ANF clearance receptor (ANFR-C). The present study was performed on anesthetized dogs, normal (control) and with experimental congestive heart failure (CHF), and was designed to investigate the ability of an ANF ligand specific for ANFR-C [C-ANF-(4-23)] to increase plasma ANF and also to evaluate the influence of ANFR-C on regional pulmonary and renal ANF clearances. C-ANF-(4-23) increased plasma ANF in controls (51 +/- 15 to 123 +/- 39 pg/ml; P < 0.05) and further increased plasma ANF in CHF dogs (242 +/- 30 to 327 +/- 34; P < 0.05), demonstrating that ANFR-C plays a significant role in the overall metabolism and clearance of ANF, even with chronically elevated ANF. Infusion of C-ANF-(4-23) produced a marked decrease in ANF pulmonary clearance (PCLANF) in controls (1,018 +/- 405 to -286 +/- 383 ml/min; P < 0.05); however, PCLANF was not altered by the ANF ligand in CHF dogs [-137 +/- 174 to -106 +/- 226 ml/min; not significant (NS)], suggesting an occupancy of ANFR-C or a downregulation of this receptor with chronically elevated plasma ANF. ANF renal clearance (RCLANF) was not altered in either group by C-ANF-(4-23) infusion.(ABSTRACT TRUNCATED AT 250 WORDS)

Sign in / Sign up

Export Citation Format

Share Document