scholarly journals A randomised study of peginterferon and ribavirin for 16 versus 24 weeks in patients with genotype 2 chronic hepatitis C

Gut ◽  
2007 ◽  
Vol 56 (4) ◽  
pp. 553-559 ◽  
Author(s):  
M.-L. Yu ◽  
C.-Y. Dai ◽  
J.-F. Huang ◽  
N.-J. Hou ◽  
L.-P. Lee ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Randomised Study ◽  
Genotype 2 ◽  
Peginterferon And Ribavirin

Early prediction of sustained virological response at day 3 of treatment with albinterferon-α-2b in patients with genotype 2/3 chronic hepatitis C

2009 ◽  
Vol 29 (9) ◽  
pp. 1350-1355 ◽  
Author(s):  
Avidan U. Neumann ◽  
Vincent G. Bain ◽  
Eric M. Yoshida ◽  
Keyur Patel ◽  
Erik Pulkstenis ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Early Prediction ◽  
Genotype 2

High risk of aminotransferase flares in patients with chronic hepatitis C genotype 2

2002 ◽  
Vol 36 ◽  
pp. 245
Author(s):  
Maria Grazia Rumi ◽  
Francesca De Filippi ◽  
Carlo La Vecchia ◽  
Silvano Gallus ◽  
Roberta Soffredini ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
High Risk ◽  
Chronic Hepatitis C ◽  
Genotype 2

scholarly journals IFNL4polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C

2016 ◽  
Vol 47 (3) ◽  
pp. E5-E13 ◽  
Author(s):  
Nami Mori ◽  
Michio Imamura ◽  
Yoshiiku Kawakami ◽  
Yuko Nagaoki ◽  
Tomokazu Kawaoka ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Older Patients ◽  
Genotype 1 ◽  
Peginterferon And Ribavirin

scholarly journals Efficacy of dual therapy in patients >65 years old with alanine transaminase flare during chronic hepatitis C genotype 2

2015 ◽  
Vol 9 (1) ◽  
pp. 82
Author(s):  
Elena Garlatti Costa ◽  
Michela Ghersetti ◽  
Silvia Grazioli ◽  
Pietro Casarin
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Dual Therapy ◽  
Alanine Transaminase ◽  
Genotype 2

scholarly journals Chronic hepatitis C virus infections in Brazilian patients: association with genotypes, clinical parameters and response to long term alpha interferon therapy

1999 ◽  
Vol 41 (3) ◽  
pp. 183-189 ◽  
Author(s):  
Leda BASSIT ◽  
Luiz C. DA SILVA ◽  
Gabriela RIBEIRO-DOS-SANTOS ◽  
Geert MAERTENS ◽  
Flair J. CARRILHO ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hcv Infection ◽  
Sustained Response ◽  
Response To Treatment ◽  
Recombinant Interferon ◽  
Genotype 2

The present study assessed the clinical significance of hepatitis C virus (HCV) genotypes and their influence on response to long term recombinant-interferon-alpha (r-IFN-<FONT FACE="Symbol">a</FONT>) therapy in Brazilian patients. One hundred and thirty samples from patients previously genotyped for the HCV and with histologically confirmed chronic hepatitis C (CH-C) were evaluated for clinical and epidemiological parameters (sex, age, time of HCV infection and transmission routes). No difference in disease activity, sex, age or mode and time of transmission were seen among patients infected with HCV types 1, 2 or 3. One hundred and thirteen of them were treated with 3 million units of r-IFN-<FONT FACE="Symbol">a</FONT>, 3 times a week for 12 months. Initial response (IR) was significantly better in patients with genotype 2 (100%) and 3 (46%) infections than in patients with genotype 1 (29%) (p < 0.005). Among subtypes, difference in IR was observed between 1b and 2 (p < 0.005), and between 1b and 3a (p < 0.05). Sustained response (SR) was observed in 12% for (sub)type 1a, 13% for 1b, 19% for 3a, and 40% for type 2; significant differences were found between 1b and 2 (p < 0.001), and between 1b and 3a (p < 0.05). Moreover, presence of cirrhosis was significantly associated with non response and response with relapse (p < 0.05). In conclusion, non-1 HCV genotype and lack of histological diagnosis of cirrhosis were the only baseline features associated with sustained response to treatment. These data indicate that HCV genotyping may have prognostic relevance in the responsiveness to r-IFN-<FONT FACE="Symbol">a</FONT> therapy in Brazilian patients with chronic HCV infection, as seen in other reports worldwide.

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