scholarly journals A randomised control study of partial liquid ventilation after airway lavage with exogenous surfactant in a meconium aspiration syndrome animal model

2000 ◽  
Vol 82 (2) ◽  
pp. 160F-162 ◽  
Author(s):  
T. Nakamura
Keyword(s):  
Animal Model ◽  
Meconium Aspiration Syndrome ◽  
Exogenous Surfactant ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Meconium Aspiration ◽  
Control Study

Airway lavage with exogenous surfactant in an animal model of meconium aspiration syndrome

2005 ◽  
Vol 47 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Erquan Zhang ◽  
Takehiko Hiroma ◽  
Takeshi Sahashi ◽  
Atsuko Taki ◽  
Tatsuya Yoda ◽  
...  
Keyword(s):  
Animal Model ◽  
Meconium Aspiration Syndrome ◽  
Exogenous Surfactant ◽  
Meconium Aspiration

scholarly journals Cardiovascular Effects of Partial Liquid Ventilation (PLV) on Experimental Meconium Aspiration Syndrome (MAS) in Newborn Lambs † 1766

1998 ◽  
Vol 43 ◽  
pp. 301-301
Author(s):  
Adolf Valls-i-Soler ◽  
Elena Gastiasoro ◽  
Francisco J Alvarez ◽  
Arantza Arnaiz ◽  
Begoña Fernández-Ruanova ◽  
...  
Keyword(s):  
Cardiovascular Effects ◽  
Meconium Aspiration Syndrome ◽  
Partial Liquid Ventilation ◽  
Liquid Ventilation ◽  
Meconium Aspiration

scholarly journals Recombinant Human Superoxide Dismutase and N-Acetylcysteine Addition to Exogenous Surfactant in the Treatment of Meconium Aspiration Syndrome

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 905 ◽  
Author(s):  
Jana Kopincova ◽  
Maros Kolomaznik ◽  
Pavol Mikolka ◽  
Petra Kosutova ◽  
Juliana Topercerova ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Efficiency Index ◽  
Meconium Aspiration Syndrome ◽  
Mitogen Activated Protein Kinase ◽  
Exogenous Surfactant ◽  
Duration Of Treatment ◽  
Pulmonary Tissue ◽  
Meconium Aspiration ◽  
Oxidative Markers ◽  
Mitogen Activated Protein

This study aimed to evaluate the molecular background of N-acetylcysteine (NAC) and recombinant human superoxide dismutase (rhSOD) antioxidant action when combined with exogenous surfactant in the treatment of meconium aspiration syndrome (MAS), considering redox signalling a principal part of cell response to meconium. Young New Zealand rabbits were instilled with meconium suspension (Mec) and treated by surfactant alone (Surf) or surfactant in combination with i.v. NAC (Surf + NAC) or i.t. rhSOD (Surf + SOD), and oxygen-ventilated for 5 h. Dynamic lung-thorax compliance, mean airway pressure, PaO2/FiO2 and ventilation efficiency index were evaluated every hour; post mortem, inflammatory and oxidative markers (advanced oxidation protein products, total antioxidant capacity, hydroxynonenal (HNE), p38 mitogen activated protein kinase, caspase 3, thromboxane, endothelin-1 and secretory phospholipase A2) were assessed in pulmonary tissue homogenates. rhSOD addition to surfactant improved significantly, but transiently, gas exchange and reduced levels of inflammatory and oxidative molecules with higher impact; Surf + NAC had stronger effect only on HNE formation, and duration of treatment efficacy in respiratory parameters. In both antioxidants, it seems that targeting reactive oxygen species may be strong supporting factor in surfactant treatment of MAS due to redox sensitivity of many intracellular pathways triggered by meconium.

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