People with hyperlipidaemia who followed a dietary portfolio of cholesterol-lowering foods achieved a greater reduction in LDL cholesterol over 6 months than those who received advice to follow a low-saturated fat diet

2011 ◽  
Vol 15 (2) ◽  
pp. 57-58
Author(s):  
Lynne T Braun
Keyword(s):  
Ldl Cholesterol ◽  
Saturated Fat ◽  
Cholesterol Lowering ◽  
Dietary Portfolio

scholarly journals Tree nuts and the lipid profile: a review of clinical studies

2006 ◽  
Vol 96 (S2) ◽  
pp. S68-S78 ◽  
Author(s):  
Amy E. Griel ◽  
Penny M. Kris-Etherton
Keyword(s):  
Ldl Cholesterol ◽  
Unsaturated Fatty Acids ◽  
Saturated Fat ◽  
Healthy Foods ◽  
Cvd Risk ◽  
Cholesterol Lowering ◽  
Tree Nuts ◽  
Unsaturated Fat ◽  
Lipids And Lipoproteins ◽  
Fat Diets

Tree nuts have a fatty acid profile that favourably affects blood lipids and lipoproteins. They are low in saturated fat and high in unsaturated fatty acids and are rich sources of other nutrients. An extensive database consistently shows total and LDL cholesterol-lowering effects of diets low in saturated fat and cholesterol and high in unsaturated fat provided by a variety of tree nuts. Collectively, a summary of studies conducted to date shows that tree nuts reduce LDL cholesterol by 3–19 % compared with Western and lower-fat diets. Nuts also contain many nutrients and bioactive compounds that appear to contribute to the favourable effects on lipids and lipoproteins – these include plant sterols, dietary fibre and antioxidants. Because of their unique nutrient profile, nuts can be part of a diet that features multiple heart-healthy foods resulting in a cholesterol lowering response that surpasses that of cholesterol-lowering diets typically used to reduce CVD risk.

scholarly journals Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression

2017 ◽  
Vol 10 (4) ◽  
pp. 437-446 ◽  
Author(s):  
Sanghoon Shin ◽  
Hyung-Bok Park ◽  
Hyuk-Jae Chang ◽  
Reza Arsanjani ◽  
James K. Min ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Cholesterol Lowering ◽  
Atherosclerosis Progression ◽  
Coronary Artery Atherosclerosis

Increased Superoxide Anion Production by Platelets in Hypercholesterolemic Patients

2002 ◽  
Vol 87 (05) ◽  
pp. 796-801 ◽  
Author(s):  
Valerio Sanguigni ◽  
Pasquale Pignatelli ◽  
Daniela Caccese ◽  
Fabio Pulcinelli ◽  
Luisa Lenti ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Ldl Cholesterol ◽  
Experimental Studies ◽  
Human Platelets ◽  
Superoxide Anion Production ◽  
Cholesterol Lowering ◽  
Platelet Production ◽  
Cholesterol Levels ◽  
Anion Production ◽  
O2 Production

SummaryThe purpose of this study was to investigate the relationship between hypercholesterolemia and superoxide anion production.Experimental studies demonstrated that hypercholesterolemia is associated with enhanced cellular superoxide anion (O2 −) production. Aim of the study was to assess whether the same phenomenon occurs in humans.Lipid profile and platelet O2 − production were measured in 28 patients with hypercholesterolemia, compared with 25 age- and sexmatched healthy subjects, and in 21 out of the 28 patients after 8-week treatment with 10 mg/day atorvastatin (a HMGCoA reductase inhibitor). In order to assess the mechanism by which LDL cholesterol interferes with platelet production of O2 −, human platelets were incubated with LDL cholesterol in the presence of either an inhibitor of the phospholipaseA2 enzyme, AACOCF3, or an inhibitor of NADH/NADPH oxidases, DPI.O2 − platelet generation was significantly higher (p <0.001) and significantly related to LDL cholesterol (p < 0.001 ) in patients as compared to controls. 8-week treatment with 10 mg/day atorvastatin significantly reduced both LDL cholesterol and O2 − platelet production. This effect was partially related to the cholesterol-lowering, in that three days of treatment with atorvastatin significantly decreased platelet O2 − production, while no significant change in LDL-cholesterol levels was observed. Platelets incubated with LDL cholesterol showed O2 − release by atorvastatin is partially related to cholesterol lowering effect, suggesting that other mechanisms could be responsible for the antioxidant activity of the drug.

Abstract 186: Reduction Of High density lipoprotein Cholesterol After Successfull Dietary Intervention Is Not Accompanied By A Change In Reverse Cholesterol Transport

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Rudolf Poledne
Keyword(s):  
Reverse Cholesterol Transport ◽  
Ldl Cholesterol ◽  
Dietary Cholesterol ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Cholesterol Transport ◽  
High Cholesterol ◽  
Unsaturated Fat ◽  
Low Cholesterol

Substitution of dietary saturated fat by unsaturated fat and the reduction of dietary cholesterol intake leads to a decrease of LDL cholesterol concentration accompanied usually by a decrease of HDL cholesterol. Method: 18 young male volunteers were fed for 4 weeks either a high cholesterol saturated fat diet or low cholesterol and unsaturated fat diet in crossover design. At the end of both experimental periods, the lipoprotein concentration was determined. In addition, the reverse cholesterol transport from 14 C cholesterol labeled macrophages in tissue cultures was analyzed. Reverse cholesterol transport was calculated as the percentage of radioactivity released from pre-labeled cells to incubation media with serum of each individuals. Results: Highly significant decrease of LDL cholesterol after the unsaturated fat diet was accompanied by a significant decrease of the HDL cholesterol from 1.25 mmol/l to 1.05 mmol/l. Reverse cholesterol transport did not significantly change when the data of high cholesterol saturated fat diet (9.97 ± 1.45) and low cholesterol unsaturated fat diet (9.53 ± 1.41) were compared. There was no correlation between data of the decrease of HDL cholesterol concentration and change in reverse cholesterol transport. Conclusion: We conclude that dietary treatment by hypocholesterolemic diet accompanied by a reduction of HDL cholesterol does not lead to the decrease in reverse cholesterol transport.

scholarly journals Public health guidelines should recommend reducing saturated fat consumption as much as possible: Debate Consensus

2020 ◽  
Vol 112 (1) ◽  
pp. 25-26 ◽  
Author(s):  
Ronald M Krauss ◽  
Penny M Kris-Etherton
Keyword(s):  
Public Health ◽  
Cardiovascular Disease ◽  
General Health ◽  
Ldl Cholesterol ◽  
Saturated Fat ◽  
Research Needs ◽  
Cholesterol Reduction ◽  
Cvd Risk ◽  
Ongoing Debate ◽  
Fat Consumption

ABSTRACT There is ongoing debate as to whether public health guidelines should advocate reducing SFA consumption as much as possible to reduce the risk of chronic diseases, especially cardiovascular disease (CVD). In considering both sides of this question, we identified a number of points of agreement, most notably that the overall dietary patterns in which SFAs are consumed are of greater significance for cardiometabolic and general health than SFA intake alone. Nevertheless, there remained significant disagreements, centered largely on the interpretation of evidence bearing on 4 major questions: 1) does reducing dietary SFAs lower the incidence of CVD, 2) is the LDL-cholesterol reduction with lower SFA intake predictive of reduced CVD risk, 3) do dietary SFAs affect factors other than LDL cholesterol that may impact CVD risk, and 4) is there a sufficient rationale for setting a target for maximally reducing dietary SFAs? Finally, we identified specific research needs for addressing knowledge gaps that have contributed to the controversies.

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