scholarly journals Review: high dose vitamin E supplementation is associated with increased all cause mortality

2005 ◽  
Vol 8 (3) ◽  
pp. 82-82
Author(s):  
C. Mariano
Keyword(s):  
Vitamin E ◽  
High Dose ◽  
All Cause Mortality ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

scholarly journals Serum Metabolomic Response to Low and High Dose Vitamin E Supplementation in Two Randomized Controlled Trials

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1810-1810
Author(s):  
Jiaqi Huang ◽  
Stephanie Weinstein ◽  
Wendy Mack ◽  
Howard Hodis ◽  
Demetrius Albanes
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Prevention ◽  
Low Dose ◽  
Alpha Tocopherol ◽  
P Value ◽  
High Dose ◽  
Atbc Study ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

Abstract Objectives Vitamin E is an essential micronutrient and critical human antioxidant that has been tested for cancer and cardiovascular preventative effects for decades with conflicting results. For example, prostate cancer incidence was reduced by a low-dose vitamin E supplement in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, but the findings were not replicated by high-dose vitamin E trials such as the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The present investigation examined the serum metabolomic responses to low- and high-dose vitamin E supplementation in order to gain biological insight into the divergent trial outcomes. Methods We examined baseline and on-study serum samples for 154 men randomly assigned to receive 400 IU vitamin E (as alpha-tocopheryl acetate; ATA) or placebo daily in the Vitamin E Atherosclerosis Prevention Study (VEAPS), and 100 men administered 50 IU ATA or placebo daily in the ATBC Study. Over 970 known metabolites were identified using an ultrahigh-performance LC-MS/MS platform. Linear regression models estimated the change in serum metabolites of men supplemented with vitamin E to those assigned to placebo in VEAPS compared with ATBC. Results Serum alpha-carboxyethyl hydrochroman (CEHC) sulfate, alpha-tocopherol, and beta-/gamma-tocopherol were significantly altered by supplementation with ATA in both the VEAPS and ATBC trials (all P-values ≤ 5.1 × 10−5, the Bonferroni multiple-comparisons corrected statistical threshold). Serum C22 lactone sulfate was also significantly decreased in response to the high-dose vitamin E supplement in VEAPS (β = −0.70, P-value = 8.1 × 10−6), but not altered in the low-dose ATBC trial (β = −0.17, P-value = 0.4). Additionally, changes in several androgenic steroid metabolites were strongly related to the vitamin E supplement-associated change in C22 lactone sulfate only in the high-dose VEAPS trial. Conclusions We found evidence of a dose-dependent vitamin E supplementation effect on a novel C22 lactone sulfate compound as well as several androgenic steroids that may have relevance to previous controlled trial findings for prostate cancer. Funding Sources This research was supported by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Department of Health and Human Services.

scholarly journals The Safety of High-Dose Vitamin E Supplementation in Healthy Japanese Male Adults.

2002 ◽  
Vol 48 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Takao MORINOBU ◽  
Ryoichi BAN ◽  
Sosuke YOSHIKAWA ◽  
Takuji MURATA ◽  
Hiroshi TAMAI
Keyword(s):  
Vitamin E ◽  
High Dose ◽  
Japanese Male ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

1200 High-dose vitamin E supplementation does not diminish ribavirin-associated hemolysis in chronic hepatitis C

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 736-737
Author(s):  
J BAJAJ ◽  
K SAEIAN ◽  
J FRANCO ◽  
R VARMA ◽  
J KNOX ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Vitamin E ◽  
Chronic Hepatitis C ◽  
High Dose ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

Lower dietary n-6 : n-3 ratio and high-dose vitamin E supplementation improve sperm morphology and oxidative stress in boars

2017 ◽  
Vol 29 (5) ◽  
pp. 940 ◽  
Author(s):  
Qing Liu ◽  
Yuanfei Zhou ◽  
Runjia Duan ◽  
Hongkui Wei ◽  
Siwen Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Antioxidant Capacity ◽  
Sperm Morphology ◽  
Tocopherol Content ◽  
High Dose ◽  
Beneficial Effects ◽  
And Oxidative Stress ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

A 2 × 2 factorial experiment (10 boars per treatment) was conducted for 16 weeks to evaluate the effects of the dietary n-6 : n-3 ratio (14 : 1 vs 6 : 1) and vitamin E (200 vs 400 mg kg–1) on boar sperm morphology and oxidative stress. Sperm mitochondrial membrane potential (MMP), reactive oxygen species (ROS), DNA damage (8-hydroxydeoxyguanosine; 8-OHdG), seminal lipoperoxidation (malondialdehyde; MDA) and antioxidant capacity in the serum, spermatozoa and seminal plasma were assessed as indicators of oxidative stress. Sperm production was similar among groups but increased (P < 0.05) throughout the 16 weeks of the study. Although sperm α-tocopherol content, ROS and seminal MDA did not differ between the two dietary n-6 : n-3 ratio treatments, enhanced antioxidant enzyme activity and MMP, but decreased 8-OHdG, were found in spermatozoa from boars consuming the 6 : 1 diet. The diet with the 6 : 1 ratio positively affected sperm morphology at Weeks 12 and 16 (P < 0.05). The α-tocopherol content and antioxidant capacity increased in boars with increasing levels of vitamin E supplementation. Compared with low-dose vitamin E, high-dose vitamin E supplementation improved sperm morphology. Overall, the results indicate that an n-6 : n-3 ratio of 6 : 1 and 400 mg/kg vitamin E have beneficial effects on sperm morphology by improving antioxidative stress.

Effect of feeding T-2 toxin contaminated feed on the utilisation of vitamin E in chickens

2007 ◽  
Vol 55 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Maria Weber ◽  
Sz. Stiller ◽  
K. Balogh ◽  
L. Wágner ◽  
Márta Erdélyi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Blood Plasma ◽  
Broiler Chickens ◽  
High Dose ◽  
Plasma Vitamin ◽  
Moderate Increase ◽  
Plasma Vitamin E ◽  
Effect Of Feeding ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

The purpose of the present study was to investigate the effect of experimental T-2 toxin load (2.35 mg/kg of feed) and vitamin E supply in the drinking water (10.5 mg/bird/day) on vitamin E levels of the blood plasma and liver in broiler chickens in a 14-day experiment. It was found that T-2 toxin load did not influence vitamin E content of the blood plasma except at day 3 after the toxin load when a moderate increase was detected in plasma vitamin E. No significant changes were found in vitamin E content of the liver. The simultaneous use of high-dose vitamin E supplementation and T-2 toxin load caused a significantly higher plasma vitamin E content but the changes were less expressed in the group subjected to T-2 toxin load. Vitamin E supply also resulted in a marked and significant increase in vitamin E concentrations of the liver on days 3 and 7 even in the T-2 loaded group, but this concentration significantly decreased thereafter. The results show that T-2 contamination of the diet has an adverse effect on the utilisation of vitamin E in broiler chickens.

scholarly journals Serum Metabolomic Response to Low- and High-Dose Vitamin E Supplementation in Two Randomized Controlled Trials

2020 ◽  
Vol 29 (7) ◽  
pp. 1329-1334
Author(s):  
Jiaqi Huang ◽  
Howard N. Hodis ◽  
Stephanie J. Weinstein ◽  
Wendy J. Mack ◽  
Joshua N. Sampson ◽  
...  
Keyword(s):  
Vitamin E ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
High Dose ◽  
Randomized Controlled ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation
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