Daily folic acid supplementation for 3 years reduced age related hearing loss

2007 ◽  
Vol 10 (3) ◽  
pp. 88-88
Author(s):  
C. Auerhahn
Keyword(s):  
Hearing Loss ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Folic acid supplementation increases cutaneous vasodilator sensitivity to sympathetic nerve activity in older adults

2017 ◽  
Vol 312 (5) ◽  
pp. R681-R688 ◽  
Author(s):  
Anna E. Stanhewicz ◽  
Jody L. Greaney ◽  
Lacy M. Alexander ◽  
W. Larry Kenney
Keyword(s):  
Older Adults ◽  
Folic Acid ◽  
Sympathetic Nerve ◽  
Human Subjects ◽  
Folic Acid Supplementation ◽  
Double Blind ◽  
Doppler Flowmetry ◽  
Acid Supplementation ◽  
Age Related ◽  
Vascular Responsiveness

During heat stress, blunted increases in skin sympathetic nervous system activity (SSNA) and reductions in end-organ vascular responsiveness contribute to the age-related reduction in reflex cutaneous vasodilation. In older adults, folic acid supplementation improves the cutaneous vascular conductance (CVC) response to passive heating; however, the influence of folic acid supplementation on SSNA:CVC transduction is unknown. Fourteen older adults (66 ± 1 yr, 8 male/6 female) ingested folic acid (5 mg/day) or placebo for 6 wk in a randomized, double-blind, crossover design. In protocol 1, esophageal temperature (Tes) was increased by 1.0°C (water-perfused suit) while SSNA (peroneal microneurography) and red cell flux in the innervated dermatome (laser Doppler flowmetry; dorsum of the foot) were continuously measured. In protocol 2, two intradermal microdialysis fibers were placed in the skin of the lateral calf for graded infusions of acetylcholine (ACh; 10−10 to 10−1 M) with and without nitric oxide synthase (NOS) blockade (20 mM nitro-l-arginine methyl ester). Folic acid improved reflex vasodilation (46 ± 4% vs. 31 ± 3% CVCmax for placebo; P < 0.001) without affecting the increase in SSNA (Δ506 ± 104% vs. Δ415 ± 73% for placebo; NS). Folic acid increased the slope of the SSNA-to-CVC relation (0.08 ± 0.02 vs. 0.05 ± 0.01 for placebo; P < 0.05) and extended the response range. Folic acid augmented ACh-induced vasodilation (83 ± 3% vs. 66 ± 4% CVCmax for placebo; P = 0.002); however, there was no difference between treatments at the NOS-inhibited site (53 ± 4% vs. 52 ± 4% CVCmax for placebo; NS). These data demonstrate that folic acid supplementation enhances reflex vasodilation by increasing the sensitivity of skin arterioles to central sympathetic nerve outflow during hyperthermia in aged human subjects.

Risk Factors of Age-related Hearing Loss, Adults over 65 Years in Korea: Including the Effect of the War Participation

2016 ◽  
Vol 17 (2) ◽  
pp. 68-73
Author(s):  
Dong-Wook Kim ◽  
Tae-Young Lee ◽  
Da-Hye Choi ◽  
Taek-Yeong Kim ◽  
Hyun-Chul Moon
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Age Related ◽  
Age Related Hearing Loss
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