Problem-solving therapy reduces disability more than supportive therapy in older adults with major depression and executive dysfunction

2011 ◽  
Vol 14 (3) ◽  
pp. 77-77
Author(s):  
B. H. Mulsant
2011 ◽  
Vol 68 (1) ◽  
pp. 33 ◽  
Author(s):  
George S. Alexopoulos ◽  
Patrick J. Raue ◽  
Dimitris N. Kiosses ◽  
R. Scott Mackin ◽  
Dora Kanellopoulos ◽  
...  

2010 ◽  
Vol 167 (11) ◽  
pp. 1391-1398 ◽  
Author(s):  
Patricia A. Areán ◽  
Patrick Raue ◽  
R. Scott Mackin ◽  
Dora Kanellopoulos ◽  
Charles McCulloch ◽  
...  

2016 ◽  
Vol 24 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Kristen A. Gustavson ◽  
George S. Alexopoulos ◽  
Grace C. Niu ◽  
Charles McCulloch ◽  
Tanya Meade ◽  
...  

2020 ◽  
Vol 32 (4) ◽  
pp. 485-493
Author(s):  
Dora Kanellopoulos ◽  
Paul Rosenberg ◽  
Lisa D. Ravdin ◽  
Dalynah Maldonado ◽  
Nimra Jamil ◽  
...  

ABSTRACTObjectives:Antidepressants have limited efficacy in older adults with depression and cognitive impairment, and psychosocial interventions for this population have been inadequately investigated. Problem Adaptation Therapy (PATH) is a psychosocial intervention for older adults with major depression, cognitive impairment, and disability.Design:This study tests the efficacy of PATH versus Supportive Therapy for Cognitively Impaired Older Adults (ST-CI) in reducing depression (Montgamery Asberg Depression Rating Scale [MADRS]) and disability (World Health Organization Disability Assessments Schedule-II [WHODAS-II]) and improving cognitive outcomes (Mini Mental State Examination [MMSE]) over 24 weeks (12 weeks of treatment and 12-week post-treatment follow-up).Setting:Participants were recruited through collaborating community agencies of Weill Cornell Institute of Geriatric Psychiatry. Both interventions and all research assessments were conducted at home.Participants:Thirty-five older adults (age ≥ 65 years) with major depression and cognitive impairment no dementia (CIND).Interventions:PATH aims to increase emotion regulation by incorporating a problem-solving approach, teaching compensatory strategies, and inviting caregiver participation. Supportive Therapy aims to facilitate the expression of affect, as well as promote empathy.Measurements:Depression was measured using the MADRS, disability using the WHODAS-II, and cognition using the MMSE.Results:PATH participants showed significantly greater reduction in MADRS total score (7.04 points at 24 weeks, treatment group by time interaction: F[1,24.4] = 7.61, p = 0.0108), greater improvement in MMSE total score (2.30 points at 24 weeks, treatment group by time interaction: F[1,39.8] = 13.31, p = 0.0008), and greater improvement in WHODAS-II total score (2.95 points at 24 weeks, treatment group by time interaction: F[1,89] = 4.93, p = 0.0290) than ST-CI participants over the 24-week period.Conclusions:PATH participants had better depression, cognitive, and disability outcomes than ST-CI participants over 6 months. PATH may provide relief to depressed older adults with CIND who currently have limited treatment options.


2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 18-18
Author(s):  
S. Cummings

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